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| 1 | 雌激素减少与代谢综合征关系的实验研究显示文摘目的:探讨雌激素减少与代谢综合征的相关性。方法:在基因库中搜索已知的对脂肪组织有影响的10个基因,筛选其启动子中可能存在的雌激素调控因子的基因。以不同月龄、不同基因型的卵泡刺激素受体敲除(FORKO)雌鼠为动物模型,测量其腹内白色脂肪组织(WAT)重量、体重,计算腹内WAT与体重的比率;口服葡萄糖(2g/kg),测快速血糖(0,30,60,120min)行葡萄糖耐量实验;用组织学方法观察脂肪细胞、肝脏细胞的形态;用放射免疫法测定血清瘦素。结杲:①在7个肥胖相关基因中找到了可能的雌激素调控位点;②FORKO雌鼠于3月龄时出现肥胖,腹内WAT的重量明显高于野生型(P〈0.05);③FORKO雌鼠随月龄的增长葡萄糖耐量逐渐减低(P〈0.05);④FORKO雌鼠腹内WAT细胞在3月龄时体积较小,表现为增生(P〈0.05),而在8个月时表现为肥大(P〈0.05);⑤FORKO雌鼠于8月龄时WAT细胞、棕色脂肪(BAT)细胞及肝细胞内均有大量脂酯颗粒堆积;⑥月龄3~5个月的FORKO雌鼠空腹的血清瘦素水平均明显高于野生雌鼠(P〈0.05)。结论:FORKO雌鼠因雌激素减少而表现出腹型肥胖、高血糖、高瘦素和胰岛素抵抗等代谢紊乱,提示雌激素减少可导致代谢综合征。 | 王敏 王磊 任续功 单祥鸣 吴丽娜 吕春梅 袁广梅 M.Ram Sairam Natalia Danilovich | 2006 | 山东大学学报(医学版)2006，44，5： | 12 |
| 2 | Intercellular communication between sertoli cells and Leydig cells in the absence of follicle stimulating hormone receptor signaling 显示文摘 | Krishnamurthy H Kats R Danilovich N | 2001 | Biol Report2001，64，5： | 1 |
| 3 | Intercellular communication between sertoli cells and Leydig cells in the absence of follicle stimulating hormone receptor signaling显示文摘 | Krishnamurthy H Kats R Danilovich N | 2001 | Biol Report2001，64，5： | 1 |
| 4 | Linkage disequlibrium in the DTNBP1(dysbindin)gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel:findings from identity by descent haplotype sharing analysis显示文摘 | Kohn Y Danilovich E Filon D | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，128，1： | 1 |
| 5 | Linkage disequlibrium in the DTNBP1 (dysbindin)gene region and on chromosome lp36 among psychotic patients from a genetic isolate in Isra- el:findings from identity by descent haplotype sharing analy sis显示文摘 | Kohn Y Danilovich E Filon D | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，128，1： | 1 |
| 6 | Ovarian follicle apoptosis in bovine growth factor hormone transgenic mice显示文摘 | Bartke A Winters T A | 2000 | Biol Reprod2000，62，1： | 1 |
| 7 | Ovarian follicle apoptosis in bovine growth hormone transgenic mice显示文摘 | Danilovich N A Bartke A Winters T A | 2000 | Biology of Reproduction2000，62，： | 1 |
| 8 | The menopausal mouse:a new neural paradigm of a distressing human condition显示文摘 | Danilovich N Sairam MR Maysinger D | 2003 | Neuroreport2003，14，12： | 1 |
| 9 | Qualitative and quantitative decline in spermatogenesis of the folli-cle-stimulating hormone receptor knockout (FORKO) mouse 显示文摘 | Krishnamurthy H Danilovich N Morales CR | 2000 | Biol Reprod2000，62，： | 1 |
| 10 | The menopausalmouse:anew neural paradigm of a distressing human condition显示文摘 | Danilovich N Sairam MR Maysinger D | 2003 | Neuroreport2003，14，12： | 1 |
| 11 | Estrogen deficiency, obesity, and skeletal abnormalities, in follicle-stimulating hormone receptor knockout (FORK O) female mice显示文摘 | Babu PS Xing W | 2000 | Endocrinology2000，141，11： | 1 |
| 12 | Dynamics of ovarian development in the FORKO immature mouse: Structural and functional implications for ovarian reserve显示文摘 | Balla A Danilovich N Yang Y | 2003 | Biol Reprod2003，69，： | 1 |
| 13 | Developmental and molocular aberrations associated with deterioration of oogenesis during complete or partial follicle-stimulating hormone receptor deficiency in mice显示文摘 | Yang Y Balla A Danilovich N | 2003 | Biol Reprod2003，69，： | 1 |
| 14 | Early obesity and age-related mimicry of metabolic syndrome in female mice with sex hormonal imbalances显示文摘 | Wang M Danilovich N | 2006 | Obesity(Silver Spring)2006，14，： | 1 |
| 15 | Combined biologic (anaerobic-aerobic) and chemical treatment of starch industry wastewater显示文摘 | Vladimir Sklyar Andrey Epov Marina Gladchenko Dmitrii Danilovich Sergey Kalyuzhnyi | 2003 | Applied Biochemistry and Biotechnology (-)2003，，1： | 1 |
| 16 | Hormone induced receptor gene splicing variant: enhanced expression of the growth factor type Ⅰ follicle stimulating hormone receptor motif in the developing mouse ovary as a new paradigm in growth regulation显示文摘 | Babu P S Danilovich N Sairam M R | 2001 | Endocrinology2001，142，： | 1 |
| 17 | On periodic groups with prescribed orders of elements显示文摘This is a survey of results and open problems concerning the structure of periodic group with prescribed orders of their elements. In particular, an outline of a proof of the following recent result is given: every periodic group whose set of element orders coincides with {1,2,3,4,8} is locally finite. | MAZUROV Victor Danilovich | 2009 | Science China Mathematics2009，52，2： | 1 |
| 18 | Hormone-induced receptor gene splicing:enhanced expression of the growth factor type I follicle-stimulating hormone receptor motif in the developing mouse ovary as a new paradigm in growth regulation显示文摘 | Babu PS Danilovich N Sairam MR | 2001 | Endocrinology2001，142，1： | 1 |
| 19 | Ovarian follicle apoptosis in bovine growth hormone transgenic mice显示文摘 | Danilovich N Bartke A Winters T A | 2000 | Biology of Repro-duction2000，62，： | 1 |
| 20 | Deficits in female reproductive function in GH-RKO mice;role of IGF-I显示文摘 | Danilovich N Wernsing D Coschigano K T | 1999 | Endocrinology1999，140，6： | 1 |
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