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您的检索式：作者名="Daniel P.Bezerra"
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| 1 | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells显示文摘Colorectal cancer(CRC)represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide.The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells(CSCs),which present both pluripotency and self-renewal properties.These cells are considered responsible for the progression of the disease,recurrence and tumor resistance.Interestingly,some cell signaling pathways participate in CRC survival,proliferation,and selfrenewal properties,and most of them are dysregulated in CSCs,including the Wingless(Wnt)/β-catenin,Notch,Hedgehog,nuclear factor kappa B(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),peroxisome proliferator-activated receptor(PPAR),phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin(PI3K/Akt/mTOR),and transforming growth factor-β(TGF-β)/Smad pathways.In this review,we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways,which will contribute to the study of potential therapeutic schemes,combining conventional drugs with CSC-targeting drugs,and allowing better cure rates in anti-CRC therapy. | Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.Quadros Daniel P.Bezerra | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | 靶向信号通路杀伤结直肠癌干细胞的新型药物显示文摘在全球范围内,结直肠癌(colorectal cancer,CRC)是第三大最常见的癌症,也是第二大致死的癌症。目前癌症生物学认为,癌是由一小群肿瘤干细胞(cancer stem cells,CSCs)形成,CSCs具有多潜能和自我更新的特性。CSCs被认为是与肿瘤发展、复发和耐药性有关。有趣的是,一些细胞信号通路参与维持CRC的存活、增殖和自我更新的特性,其中大多数信号通路在CSCs中被异常调控,这些通路包括Wnt(Wingless)/β-catenin、Notch、Hedgehog、NF-κB(nuclear factor kappa B)、JAK/STAT(Janus kinase/signal transducer and activator of transcription)、PPAR(peroxisome proliferator-activated receptor)、PI3K/Akt/mTOR(phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin)和TGF-β(transforming growth factor-β)/Smad信号通路。在本综述中,我们总结了当前通过调控使这些异常信号通路来杀伤CRC干细胞的策略,这将有可能探索出联合常规药物和CSCs靶向药物的治疗方案,并将有助于提高CRC的治愈率。 | Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.Quadros Daniel P.Bezerra | 2023 | 癌症2023，42，4： | 0 |
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