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您的检索式：作者名="Dameng Yin"
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| 1 | Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF,and the neutralization of miR-150 attenuate tumor development显示文摘Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic factor.During tumor development,TAMs secrete VEGF and other factors to promote angiogenesis;thus,anti-treatment against TAMs and VEGF can repress cancer development,which has been demonstrated in clinical trials and on an experimental level.In the present work,we show that miR-150 is an oncomir because of its promotional effect on VEGF.MiR-150 targets TAMs to up-regulate their secre-tion of VEGF in vitro.With the utilization of cell-derived vesicles,named microvesicles(MVs),we transferred an-tisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis.There-fore,we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel,natu-ral,microvesicle-based method for the transfer of nucleic acids. | Yuchen Liu Luming Zhao Dameng Li Yuan Yin Chen-Yu Zhang Jing Li Yujing Zhang | 2013 | Protein & Cell2013，4，12： | 18 |
| 2 | Stacked spectral feature space patch: An advanced spectral representation for precise crop classification based on convolutional neural network显示文摘Spectral and spatial features in remotely sensed data play an irreplaceable role in classifying crop types for precision agriculture. Despite the thriving establishment of the handcrafted features, designing or selecting such features valid for specific crop types requires prior knowledge and thus remains an open challenge. Convolutional neural networks(CNNs) can effectively overcome this issue with their advanced ability to generate high-level features automatically but are still inadequate in mining spectral features compared to mining spatial features. This study proposed an enhanced spectral feature called Stacked Spectral Feature Space Patch(SSFSP) for CNN-based crop classification. SSFSP is a stack of twodimensional(2 D) gridded spectral feature images that record various crop types’ spatial and intensity distribution characteristics in a 2 D feature space consisting of two spectral bands. SSFSP can be input into2 D-CNNs to support the simultaneous mining of spectral and spatial features, as the spectral features are successfully converted to 2 D images that can be processed by CNN. We tested the performance of SSFSP by using it as the input to seven CNN models and one multilayer perceptron model for crop type classification compared to using conventional spectral features as input. Using high spatial resolution hyperspectral datasets at three sites, the comparative study demonstrated that SSFSP outperforms conventional spectral features regarding classification accuracy, robustness, and training efficiency. The theoretical analysis summarizes three reasons for its excellent performance. First, SSFSP mines the spectral interrelationship with feature generality, which reduces the required number of training samples.Second, the intra-class variance can be largely reduced by grid partitioning. Third, SSFSP is a highly sparse feature, which reduces the dependence on the CNN model structure and enables early and fast convergence in model training. In conclusion, SSFSP has great potential for practical crop classification in precision agriculture. | Hui Chen Yue’an Qiu Dameng Yin Jin Chen Xuehong Chen Shuaijun Liu Licong Liu | 2022 | The Crop Journal2022，10，5： | 1 |
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