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60篇 您的检索式:作者名="Dadon"
    题名 作者 年代 出处 被引量
1Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch 2013Cell Research2013,23,10:65
2Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice显示文摘Goldenberg-Cohen N Dratviman-Storobinsky O Dadon Bar E1 S 2011J Neuroophthalmol2011,31,:1
3Ghost-cell method with far field coarsening and mesh adaptation for Cartesian grids 显示文摘DADONE A GROSSMAN B 2006Computers & Fluids2006,35,7:1
4Ghost-Cell method for inviscid two-dimensional flows on cartesian grids 显示文摘DADONE A GROSSMAN B 2004AIAA Journal2004,42,12:1
5Ghost-cell method for inviscid three-dimensional flows on cartesian grids 显示文摘DADONE A GROSSMAN B 2007Computers & Fluids2007,36,10:1
6Performance degradation of propeller systems due to rime ice accretion 显示文摘Korkan K D Dadone L Shaw R J 1984Journal of Aircraft1984,21,1:1
7Differentiated mes- enchymal stem cells for sciatic nerve injury显示文摘Dadon NM Sadan O Srugo I 2011Stem Cells Rev2011,7,3:1
8Molecular and histological changes following central retinal artery occlusion in a mouse model显示文摘Goldenberg-Cohen N Dadon 5 Avraham BC 2008Exp Eye Res2008,87,:1
9Helicopter rotor performance degradation in natural icing encounter 显示文摘Korkan K D Dadone L Shaw R J 1984Journal of Aircraft1984,21,1:1
10Performance degradation of propeller systems due to rime ice accretion 显示文摘Korkan K D Dadone L Shaw R J 1984Journal of Aircraft1984,21,1:1
11Temporal and spatial changes in plant dune di- versity in urban resorts显示文摘Faggi A Dadon J 2011Journal of Coastal Conservation2011,15,4:1
12Proinflammatory cytokines in a mouse model of central retinal artery occlusion 显示文摘Kramer M Dadon S Hasanreisoglu M 2009Mol Vis2009,15,:1
13Performance degradation of helicopter rotor in forward flight due to ice 显示文摘Korkan K D Dadone L Shaw R J 1985Journal of Aircraft1985,22,8:1
14Unsteady flows through screens显示文摘Dadone A Napolitano M 1974Meccanica1974,9,:1
15Progressive optimization of in verse fluid dynamic design problem显示文摘Dadone A Grissman B 2000Computers and Fluids2000,29,1:1
16A panel of stress-responsive luminous bacteria for the detection of selected classes of toxicants显示文摘Belkin S Smulski D Dadon S 1997Water Res1997,31,12:1
17Human blood platelet as research tool in neuropsychopharmacology 显示文摘Bongioanni P Dadone F Donato M 1991J Neural Transm Suppl1991,33,:1
18Ghost-cell method for inviscid two-dimensional flows on Cartesian grids显示文摘Dadone A Grossman B 2004AIAA Jour- nal2004,42,24:1
19Performance degradation of propeller systems due to rime ice accretion 显示文摘Korkan K D Dadone L Shaw R J 1984Journal of Aircraft1984,21,1:1
20Performance degradation of helicopter rotor in forward flight due to ice 显示文摘Korkan K D Dadone L Shaw R J 1985Journal of Aircraft1985,22,8:1
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