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| 1 | Alteration of peripheral blood lymphocyte subsets in acute pancreatitis显示文摘AIM: To evaluate peripheral blood lymphocyte subsets in patients with acute pancreatitis (AP).METHODS: Twenty patients with mild AP (M-AP) and 15 with severe AP (S-AP) were included in our study. Pe-ripheral blood lymphocytes were examined at d 1-3, 5, 10 and 30 by means of ? ow cytometry. RESULTS: A signifi cant depletion of circulating lympho-cytes was found in AP. In the early AP, the magnitude of depletion was similar for T- and B- lymphocytes. In the late course of S-AP, B-lymphocytes were much more depleted than T-lymphocytes. At d 10, strong shift in the CD7+/CD19+ ratio implicating predominance of T- over B-lymphocytes in S-AP was found. Among T-lym-phocytes, the signifi cant depletion of the CD4+ popula-tion was observed in M-AP and S-AP, while CD8+ cells were in the normal range. Lymphocytes were found to strongly express activation markers: CD69, CD25, CD28, CD38 and CD122. Serum interleukin-2 (IL-2), IL-4, IL-5, IL-10, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were signifi cantly increased in both forms of AP. The magnitude of elevation of cytokines known to be produced by Th2 was much higher than cytokines produced by Th1 cells.CONCLUSION: AP in humans is characterized by significant reduction of peripheral blood T- and B-lymphocytes. | Miroslawa Pietruczuk Milena I Dabrowska Urszula Wereszczynska-Siemiatkowska Andrzej Dabrowski | 2006 | World Journal of Gastroenterology2006，12，33： | 15 |
| 2 | Signal transduction pathways in liver and the influence of hepatitis C virus infection on their activities显示文摘In liver,the most intensively studied transmembrane and intracellular signal transduction pathways are the Janus kinase signal transduction pathway,the mitogen-activated protein kinases signal transduction pathway,the transforming growth factor β signal transduction pathway,the tumor necrosis factor α signal transduction pathway and the recently discovered sphingolipid signal transduction pathway.All of them are activated by many different cytokines and growth factors.They regulate specific cell mechanisms such as hepatocytes proliferation,growth,differentiation,adhesion,apoptosis,and synthesis and degradation of the extracellular matrix.The replication cycle of hepatitis C virus(HCV) is intracellular and requires signal transduction to the nucleus to regulate transcription of its genes.Moreover,HCV itself,by its structural and non-structural proteins,could influence the activity of the second signal messengers.Thus,the inhibition of the transmembrane and intracellular signal transduction pathways could be a new therapeutic target in chronic hepatitis C treatment. | Magdalena M Dabrowska Anatol Panasiuk Robert Flisiak | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 3 | Estimation and Testing in a Two-sample Generalized Odds-rate Model显示文摘 | Doksum KA | 1988 | J Amer Statist Assoc1988，83，： | 1 |
| 4 | Partial likelihood in trans formation models with censored data 显示文摘 | Dabrowska D M Doksuin K A | 1988 | Scandinavian Journal of Statistics1988，15，： | 1 |
| 5 | Chronic cough - assessment of treatment efficacy based on two questionnaires 显示文摘 | Dabrowska M Grabczak EM Areimowicz M | 2014 | ArchMedSei2014，10，5： | 1 |
| 6 | Lower proportions of CD4+CD25(high)and CD4+FoxP3,but not CD4+CD25+CD127(low)FoxP3+T cell levels in children with autoimmune thyroid diseases显示文摘 | Bossowski A Moniuszko M Dabrowska M | 2013 | Autoimmunity2013，46，： | 1 |
| 7 | Interactive and Single Effects of Ectomycorrhiza Formation and Bacillus cereus on Metallothionein MT1 Expression and Phytoextraction of Cd and Zn by Willows显示文摘 | Hrynkiewicz K Dabrowska G Baum C | 2012 | Water Air Soil Pollution2012，223，3： | 1 |
| 8 | Possible association between phages, Hoc protein, and the immune system显示文摘 | DABROWSKA K SWITALA-JELEN K OPOLSKI A | 2006 | Arch Virol2006，151，2： | 1 |
| 9 | Analytical approaches to determination of carnitine in biological materials, foods and dietary supplements 显示文摘 | Dabrowska M Starek M | 2014 | Food Chem2014，142，： | 1 |
| 10 | From Formula to Schema:The Acquisition of English Questions显示文摘 | Dabrowska E | 2000 | Cognitive Linguistics2000，，1： | 1 |
| 11 | Effects of nebulized NONO ate,DPTA/NO,on group B streptococcusinduced pulmonary hypertension in newborn piglets显示文摘 | Dabrowska K Hehre D Young KC | 2005 | Pediatr Res2005，57，3： | 1 |
| 12 | Aldehyde contamination of mineral water stored in PET bottles显示文摘 | Dabrowska A Borcz A Nawrocki J | 2003 | Food Additives and Contaminants2003，20，12： | 1 |
| 13 | Arsenicuptake by plants and possible phytoremediation applications : abrief overview 显示文摘 | Vithanage M Dabrowska B B Mukherjee A B ef al | 2012 | Environmental Chemistry Letters2012，10，3： | 1 |
| 14 | Inter-tissue distribution and evaluation of potential toxicity of PCBs in Baltic cod ( Gadus morhua L.)显示文摘 | Henryka Dabrowska Ewelina Bernard Iwona Barska Krzysztof Radtke | 2009 | Ecotoxicology and Environmental Safety2009，，7： | 1 |
| 15 | CD4+ / CD25+ cells in systemic inflammation in COPD显示文摘 | Domagata-Kulawik J Hoser G Dabrowska M | 2011 | Scand J Immunol2011，73，1： | 1 |
| 16 | CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients显示文摘 | Kurzawski M Dabrowska J Dziewanowski K | 2014 | Pharmacogenomics2014，15，2： | 1 |
| 17 | Simplified method of dynamic contrast-enhanced computed tomo- graphy in the evaluation of indeterminate pulmonary nod- ules显示文摘 | Dabrowska M Zukowska M Krenke R | 2010 | Respiration2010，79，2： | 1 |
| 18 | Bacteriophage therapy in children:facts and prospects显示文摘 | Fortuna W Miedzybrodzki R Dabrowska B W | 2008 | Med Sci Monit2008，14，： | 1 |
| 19 | ATP converts necrosis to apoptosis in oxidant-injured endothelial cells 显示文摘 | Lelli JL Jr Becks LL Dabrowska MI | 1998 | Free Radic Biol Med1998，25，6： | 1 |
| 20 | Expo sure to pesticides and heavy work in greenhouses during preg nancy: does it affect birth weight?显示文摘 | Jurewicz J Hanke W Makowiec Dabrowska T | 2005 | lnt Arch Occup Envi- ron Health2005，78，41： | 1 |
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