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| 1 | Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness显示文摘AIM:To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease(IBD).METHODS:Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min.Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions.To be eligible for the study,patients needed a minimum of four prior infusions.An initial infusion of 90-min was given to each patient;those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits.Any patient having significant infusion reactions would be reverted to the standard 120-min protocol.A change in a patient's dose mandated a single 120-min infusion before accelerated infusions could be administered again.RESULTS:The University of Virginia Medical Center's Institutional Review Board approved this study.Fifty IBD patients treated with infliximab 5mg/kg,7.5mg/kg and 10mg/kg were offered accelerated infusions.Forty-six patients consented to participate in the study.Nineteen(41.3%) were female,five(10.9%) were African American and nine(19.6%) had ulcerative colitis.The mean age was 42.6 years old.Patients under age 18 were excluded.Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine,three were taking 6-mercaptopurine and one was taking methotrexate.One of the 46 study patients used corticosteroid therapy for his IBD.Seventeen of the patients used prophylactic medications prior to receiving infusions;six patients received corticosteroids as pre-medication.Four patients had a history of distant transfusion reactions to infliximab.These reactions included shortness of breath,chest tightness,flushing,pruritus and urticaria.These patients all took prophylactic medications before receiving infusions.46 patients(27 males and 19 females) received a total of fifty 90-min infusions and ninety-three 60-min infusions.No infusion reactions were reported.There were no adverse events,including drug-related infections.None of the patients developed cancer of any type during the study timeframe.Total cost savings for administration of the both 90-min and 60-min accelerated infusions compared to standard 120-min infusions was estimated to be $53 632($116 965 vs $63 333,P=0.001).One hundred and eighteen hours were saved in the administration of the accelerated infusions(17 160 min vs 10 080 min,P=0.001).In the study population,overweight females [body mass index(BMI)>25.00kg/m2] were found to have statistically higher BMIs than overweight males(mean BMI 35.07±2.66kg/m2 vs 30.08±0.99kg/m2,P=0.05),finding which is of significance since obesity was described as being one of the risk factors for Crohn's disease.CONCLUSION:We are the first US group to report substantial cost savings,increased safety and patient satisfaction associated with accelerated infliximab infusion. | John McConnell Simona Parvulescu-Codrea Brian Behm Beth Hill Elizabeth Dunkle Karen Finke Kathryn Snyder Anne Tuskey Debbie Cox Beth Woodward | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，5： | 2 |
| 2 | Combination of single-grahn fission-track chronology and morphologyical analysis of detrital zircon crystals in provenance studies-sources of the Macigno Formation (Apennines, Italy)显示文摘 | Dunkl I Giulio A D I Kuhlemann J | 2001 | Journal of Sedimentary Reareh2001，71，4： | 1 |
| 3 | New hetrosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda: an analysis of survey and clinical data 显示文摘 | Dunkle KL Stephenson R Karita E | 2008 | Lancet2008，371，9631： | 1 |
| 4 | Analysis of Cochliobolus carbonum races by PCR amplification with arbitrary and gene-specific primers 显示文摘 | Jones M L Dunkle L D | 1993 | Phytopathology1993，83，： | 1 |
| 5 | Rape perpetration by young,rural South African men:prevelance,patterns,and risk factors显示文摘 | Jewkes R Dunkle K Koss MP | 2006 | Soc Sci Med2006，63，11： | 1 |
| 6 | Combination of single-grain fission-track chronology and morphological analysis of detrital zircon crystals in provenance studies : Sources of the macigno formation ( Apennines, Italy) 显示文摘 | Dunkl I Di Giulio A Kuhlemann J | 2001 | Journal of Sedimentary Research2001，71，4： | 1 |
| 7 | Response of starch-encapsulated Bacillus thuringiensis containing ultraviolet screens to Sunlight显示文摘 | DUNKLE R L SHASHA B S | 1989 | Environ Entomol1989，18，： | 1 |
| 8 | Injuries among 4- to 9-year-old restrained motor vehicle occupants by seat location and crash impact site显示文摘 | AGRAN P WINN D DUNKLE D | 1989 | Am J Dis Child1989，143，11： | 1 |
| 9 | Starch-encapsulated Bacillus thuringiensis: a potential new method for increasing environmental stability of entomopathogens 显示文摘 | DUNKLE R L SHASHA B S | 1988 | Environ Entomol1988，17，： | 1 |
| 10 | Fas regulate germ cell apoptosis in the human testis in vitro显示文摘 | Erkkil K Dunkl L | 1999 | A m J Physiol1999，276，2： | 1 |
| 11 | Molecular recognition and modification of the 30Sribosome by the aminoglycosideresistance methyltransferase NpmA显示文摘 | Dunkle JA Vinal K Desai PM | 2014 | Proc Natl Acad Sci U S A2014，111，17： | 1 |
| 12 | The and-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages显示文摘 | Dzhagalov I Dunkle A He YW | 2008 | J Immunol2008，181，1： | 1 |
| 13 | An approximate analysis of the solar reflectance and transmittance of a snow cover显示文摘 | Bevans J T | 1956 | Journal of Meteorology1956，13，： | 1 |
| 14 | Sibling species of cereospora associated with gray leaf spot of maize显示文摘 | J WANG M LEVY L D DUNKLE | 1998 | Phytopathology1998，88，12： | 1 |
| 15 | New Heterosexually Transmitted HIV Infections in Married or Cohabiting Couples in Urban ZambiaandRwanda: an Analysis of Survey and Clinical Data显示文摘 | DUNKLE STEPHENSONR KARITAE | 2008 | Lancet2008，371，9631： | 1 |
| 16 | Quiescent-inflow single- shot magnetic resonance angiography using a highly undersampled radial K-space trajectory显示文摘 | EDELMAN R R GIRI S DUNKLE E | 2013 | Magn Reson Med2013，70，6： | 1 |
| 17 | Rapid whole-brain magnetic resonance imaging with isotropic resolution at 3 Tesla显示文摘 | Edelman R R Dunkle E Koktzoglou I et ol | 2009 | Invest Radiol2009，44，1： | 1 |
| 18 | PHL1 of Cercospora zeae-maydis encodes a member of the photolyase/cryptochrome family involved in UV protection and fungal development显示文摘 | BLUHM B H DUNKLE L D | | 0，，10： | 1 |
| 19 | Sibling species of Cercospora associated with gray leaf spot of maize显示文摘 | Wang J Levy M Dunkle L D | 1998 | Phytopathology1998，88，： | 1 |
| 20 | Determinants of E-business use in US firms显示文摘 | Hsu PF Kraemer KL Dunkle D | 2006 | International Journal of Electronic Commerce2006，10，4： | 1 |
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