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| 1 | Imaging tests for accurate diagnosis of acute biliary pancreatitis显示文摘Gallstones represent the most frequent aetiology of acute pancreatitis in many statistics all over the world, estimated between 40%-60%. Accurate diagnosis of acute biliary pancreatitis(ABP) is of outmost importance because clearance of lithiasis [gallbladder and common bile duct(CBD)] rules out recurrences. Confirmation of biliary lithiasis is done by imaging. The sensitivity of the ultrasonography(US) in the detection of gallstones is over 95% in uncomplicated cases, but in ABP, sensitivity for gallstone detection is lower, being less than 80% due to the ileus and bowel distension. Sensitivity of transabdominal ultrasonography(TUS) for choledocolithiasis varies between 50%-80%, but the specificity is high, reaching 95%. Diameter of the bile duct may be orientative for diagnosis. Endoscopic ultrasonography(EUS) seems to be a more effectivetool to diagnose ABP rather than endoscopic retrograde cholangiopancreatography(ERCP),which should be performed only for therapeutic purposes.As the sensitivity and specificity of computerized tomography are lower as compared to state-of-the-art magnetic resonance cholangiopancreatography(MRCP)or EUS,especially for small stones and small diameter of CBD,the later techniques are nowadays preferred for the evaluation of ABP patients.ERCP has the highest accuracy for the diagnosis of choledocholithiasis and is used as a reference standard in many studies,especially after sphincterotomy and balloon extraction of CBD stones.Laparoscopic ultrasonography is a useful tool for the intraoperative diagnosis of choledocholithiasis.Routine exploration of the CBD in cases of patients scheduled for cholecystectomy after an attack of ABP was not proven useful.A significant rate of the so-called idiopathic pancreatitis is actually caused by microlithiasis and/or biliary sludge.In conclusion,the general algorithm for CBD stone detection starts with anamnesis,serum biochemistry and then TUS,followed by EUS or MRCP.In the end,bile duct microscopic analysis may be performed by bile harvested during ERCP in case of recurrent attacks of ABP and these should be followed by laparoscopic cholecystectomy. | Valeriu Surlin Adrian S?ftoiu Daniela Dumitrescu | 2014 | World Journal of Gastroenterology2014，20，44： | 17 |
| 2 | Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania显示文摘AIM:To describe the relationship between vitamin D levels and inflammatory bowel disease(IBD)characteristics in northeastern Romanian patients.METHODS:This was a prospective study of 47 consecutive IBD patients admitted to The Institute of Gastroenterology and Hepatology in Iasi,Romania between March 2011 and June 2012.The diagnosis of IBD was established based on endoscopic,histologic and radiologic findings.Demographic data,disease characteristics,ongoing treatments and biological parameters of patients(including markers of inflammation:C-reactive protein level,fibrinogen level,and erythrocyte sedimentation rate)were recorded.Serum vitamin D levels were measured and compared with age-and sexmatched healthy volunteers from the same geographic area.Vitamin D levels were defined as sufficient(>30ng/mL),insufficient(20-30 ng/mL),or severely defi-cient(<20 ng/mL).RESULTS:Thirty-three of the IBD patients included in this study had ulcerative colitis(UC)and 14 had Crohn’s disease(CD).Only 24%of the UC patients and 21%of the CD patients had sufficient vitamin D levels.The vitamin D levels were significantly lower in the CD patients with moderate to severe disease activity compared to the CD patients in remission or with mild disease activity(16±6 ng/mL vs 26±7 ng/mL;16±6 ng/mL vs 31±9 ng/mL,respectively,P<0.05).Vitamin D levels in the UC patients were not influenced by disease activity and no correlation was observed with the inflammation markers tested(C-reactive protein,fibrinogen,and erythrocyte sedimentation rate).No association was observed between vitamin D levels and smoking status or ongoing medication(5ASA,steroids,and anti-TNFα).Newly diagnosed IBD patients had lower vitamin D levels than patients with established cases,though these differences were not significant(UC:22±9 ng/mL vs 26±12 ng/mL;CD:18±6 ng/mL vs 27±11 ng/mL,respectively).Although no association was found between the season during which the visit was scheduled and vitamin D levels,the UC patients assessed during the winter tended to have lower levels than those assessed during the summer(22±9 ng/mL vs 28±13 ng/mL,respectively).CONCLUSION:Vitamin D levels are significantly reduced in IBD patients in northeastern Romania,with the lowest levels occurring in CD patients with moderate to severe disease activity. | Gabriela Dumitrescu Catalina Mihai Mihaela Dranga Cristina Cijevschi Prelipcean | 2014 | World Journal of Gastroenterology2014，20，9： | 8 |
| 3 | Hybrid ultrasound imaging techniques(fusion imaging)显示文摘Visualization of tumor angiogenesis can facilitate noninvasive evaluation of tumor vascular characteristics to supplement the conventional diagnostic imaging goals of depicting tumor location,size,and morphology.Hybrid imaging techniques combine anatomic [ultrasound,computed tomography(CT),and/or magnetic resonance imaging(MRI)] and molecular(single photon emission CT and positron emission tomography) imaging modalities.One example is real-time virtual sonography,which combines ultrasound(grayscale,colour Doppler,or dynamic contrast harmonic imaging) with contrast-enhanced CT/MRI.The benefits of fusion imaging include an increased diagnostic confidence,direct comparison of the lesions using different imaging modalities,more precise monitoring of interventional procedures,and reduced radiation exposure. | Daniela Larisa Sandulescu Daniela Dumitrescu Ion Rogoveanu Adrian Saftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 7 |
| 4 | Potential roles of functional bacterial amyloid proteins,bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease显示文摘An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative conditions.The neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein,known as Lewy bodies.Some gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system,which can then spread to the brain in a prion-like fashion through the vagus nerve.Others may interfere with neuroinflammatory pathways and susceptibility to neurodegeneration.In this review,we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson’s disease,with a special emphasis on functional bacterial amyloid proteins,bacterial biosurfactants,endotoxins and short-chain fatty acids.The possible roles of molecular hydrogen,a common byproduct of bacterial fermentation,are also addressed. | EMILIA MANOLE LAURA DUMITRESCU CRISTINA NICULIȚE BOGDAN OVIDIU POPESCU LAURA CRISTINA CEAFALAN | 2021 | BIOCELL2021，45，1： | 2 |
| 5 | Globally Optimal Uneven Error - Protected Packetization of Scalable Code Streams 显示文摘 | Dumitrescu S Wu X Wang Z | 2004 | IEEE Trans Multimedia2004，6，2： | 1 |
| 6 | Social desirability, social intelligence and self-rated oral health status and behaviours显示文摘 | Dumitrescu AL Kawamura M Toma C | 2007 | Rom J Intern Med2007，45，4： | 1 |
| 7 | Panton-Valentine leukocidin is expressed at toxic levels in human skin abscesses显示文摘 | BADIOU C DUMITRESCU O CROZE M | | 0，，12： | 1 |
| 8 | A unified approach to fuzzy pattern recognition显示文摘 | Dumitrescu D Dumitrescu A | 1997 | European Journal of Operational Research1997，96，3： | 1 |
| 9 | Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growthin vivo显示文摘 | Stander M Nanmann U Dumitrescu L | 1998 | Gene Ther1998，5，9： | 1 |
| 10 | A novel syndrome combining thyroid and neurological abnomalities is sssociated with mutations in a monocarboxylate transporter gene显示文摘 | Dumitrescu AM Liao XH Best TB | 2004 | Am J Hum Genet2004，74，1： | 1 |
| 11 | Pauton-valentine leukoci- din enhances the severity of community-associated methicillin-resist- ant Staphylococcus aureus rabbit osteomyelitis 显示文摘 | Cremieux AC Dumitrescu O Lina G | 2009 | PLoS One2009，4，9： | 1 |
| 12 | McCune-Albright syndrome 显示文摘 | Dumitrescu CE Collins MT | 2008 | Orphanet J Rare Dis2008，3，： | 1 |
| 13 | Multistage IIR filter design using convex stability domains defined by positive realness 显示文摘 | B Dumitrescu R Niemist6 | 2004 | IEEE Trans on Signal Processing2004，52，4： | 1 |
| 14 | Expression of various scind-erin domains in chromaffin cells indicates that this protein acts as amolecular switch in the control of actin filament dynamics and exocy-tosis显示文摘 | Dumitrescu P T Rose S D Lejen T | 2005 | J Neurochem2005，92，4： | 1 |
| 15 | High speed face milling of a aluminium silicon alloy casting显示文摘 | NG E G SZABLEWSKI D DUMITRESCU M | 2004 | CIRP Annals - Manufacturing Technology2004，53，1： | 1 |
| 16 | Simultaneous extraction of rare earth elements and uranium from phosphoric acid 显示文摘 | Bunu F Dumitrescu R | 1992 | Hydrometallurgy1992，28，3： | 1 |
| 17 | High speed face milling of a aluminum silicon alloy casting 显示文摘 | NG E-G SZABLEWSKI D DUMITRESCU M | 2004 | Annals of the CIRP2004，53，1： | 1 |
| 18 | Expression of various scinderin domains in chromaffin ceils indicates that this protein acts as a molecular switch in the control of aetin filament dynamics and exocytosis显示文摘 | Dumitrescu Pene T Ros6 S D Lejen T | 2005 | J Neurochem2005，92，4： | 1 |
| 19 | Understanding breast cancer risk - - where do we stand in 2005显示文摘 | Dumitrescu RG Cotarla I | 2005 | J Cell Mol Meal2005，9，1： | 1 |
| 20 | Approach to the patient with resistance to thyroid hormone and pregnancy显示文摘 | Weiss RE Dumitrescu A Refetoff S | 2010 | J Clin Endocrinol Metab2010，95，： | 1 |
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