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| 1 | Hepatitis C in non-hepatic solid organ transplant candidatesand recipients:A new horizon显示文摘Hepatitis C virus(HCV) infection is estimated to affect 130-150 million people globally which corresponds to2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ transplantation. In the era of interferon-based therapy, although treatment and cure of HCV prior to nonhepatic transplant improved survival, tolerability and low cure rates substantially limited therapy. Interferon(IFN)-based therapy following non-hepatic solid organ transplant, due to the risk of allograft rejection, is generally contraindicated. Rapid advances in IFN-free therapy with direct acting antivirals(DAAs) in the last few years have completely changed the paradigm of hepatitis C therapy. Compared to IFN-based regimens, DAAs have less frequent and less severe adverse effects, shorter durations of therapy, and higher cure rates that are minimally impacted by historically negative predictors of response such as cirrhosis, ethnicity, and post-transplant state. Recent studies have shown that liver transplant(LT) recipients can be safely and effectively treated with DAA combination therapies; although data are limited, many of the principles of therapy in LT may be extrapolated to non-hepatic solid organ transplant recipients. Here we review the data on DAA combination therapies in transplantation, discuss the advantages and disadvantages of pre- vs post-transplant HCV therapy and future directions. | Sara Belga Karen Elizabeth Doucette | 2016 | World Journal of Gastroenterology2016，22，4： | 3 |
| 2 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 3 | 显示文摘 | Doucette K Fishman JA | 2004 | Clin Infect Dis2004，38，： | 1 |
| 4 | Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity显示文摘 | CORL P D PAYNE H M | 1992 | Circulation1992，85，： | 1 |
| 5 | Harmful algal blooms : Causes, impacts and detection 显示文摘 | SELLNER K G DOUCETTE G J KIRKPATRICK G J | 2003 | J Ind Microbiol Biotechnol2003，30，： | 1 |
| 6 | Effects of the spawning migration on the nutritional status of a- nadromous Atlantic salmon ( Salmo salar) : insights from stable-isotope analysis 显示文摘 | Doucett R R Booth R K Power G | 1999 | Can J Fish Aquat Sci1999，56，11： | 1 |
| 7 | Early intravenous unfractionated heparin and mortality in septic shock显示文摘 | Zarychanski R Doucette S Fergusson D | 2008 | Crit Care Med2008，36，11： | 1 |
| 8 | Prediction of aqueous diffusion coefficients for organic compounds at 25 ℃显示文摘 | Schramke J A Murphy S F Doucette W J | 1999 | Chemosphere1999，38，10： | 1 |
| 9 | Effect of thermomechanical treatment on structure and properties of 2036 aluminum alloy显示文摘 | Chaturvrdi M C Chung D W Doucette R A | 1979 | Metal Science1979，，： | 1 |
| 10 | Donorderived bacteremia in liver transplant recipients despite antibiotic prophylaxis显示文摘 | Doucette KE AI-Saif M Kneteman N | 2013 | Am J Transplant2013，13，4： | 1 |
| 11 | Validationof Doppler guide wire for intravascular measurement of coronaryartery flow velocity 显示文摘 | DOUCETTE J W CORL P D PAYNE H M | 1992 | Circulation1992，85，5： | 1 |
| 12 | Personal health records: a randomized trial of effects on elder medication safety 显示文摘 | Chrischilles EA Hourcarde JP Doucette W | 2014 | J Am Med Inform Assoc2014，21，4： | 1 |
| 13 | Effect of introcoronary nitroglycerin administration on phasic pattern and transmural distribution of flowduring coronary artery stenosis显示文摘 | Flynn AE Doucette JW | 1992 | Circulation1992，85，： | 1 |
| 14 | Exploring the capability of some GIS surface interpolators for DEM gap fil显示文摘 | Doucette P Beard K | 2000 | Photogrammetric Engineering & Remote Sensing2000，66，7： | 1 |
| 15 | A comparativestudy of G-induced injury in pilots of the F/A-18, A-7and A4显示文摘 | Knudson R McMillan D Doucette D etal | 1988 | Aviat Space Environ Med1988，59，8： | 1 |
| 16 | Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis显示文摘 | WANG F BHAT K DOUCETTE M | 2011 | CurrMolMed2011，11，6： | 1 |
| 17 | Donor‐Derived Bacteremia in Liver Transplant Recipients Despite Antibiotic Prophylaxis显示文摘 | K. E. Doucette M. Al‐Saif N. Kneteman L. Chui G. J. Tyrrell D. Kumar A. Humar | 2013 | American Journal of Transplantation2013，，4： | 1 |
| 18 | Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant显示文摘 | DOUCETTE PA WHITSON LJ CAO X | 2004 | J Biol Chem2004，275，54： | 1 |
| 19 | A universal, high recovery assay for protein quantitation through temperature programmed liquid chromatography (TPLC)显示文摘 | Dennis J. Orton Alan A. Doucette | 2013 | Journal of Chromatography B2013，，： | 1 |
| 20 | Two-layer sample prepar-ation method for MALDI Mass spectrometric analysis of protein and peptide and protein显示文摘 | Zhang N Doucette A Li L | 2001 | Anal Chem2001，73，： | 1 |
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