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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea 显示文摘 | N M Donofrio Y Oh R Lundy | 2006 | Fungal Genetics and Biology2006，43，9： | 1 |
| 3 | Expanding the use of neurotoxins in facial aestheties:a consensus panel's assessment and recommendations显示文摘 | KANE M DONOFRIO L ASCHER B | 2010 | J Drugs Dermatol2010，9，1： | 1 |
| 4 | Abnormal callose response phenotype and hypersusceptibility to Peronospora parasitica in defense-compromised Arabidopsis nim 1-1 and salicylate hydroxylase-expressing plants显示文摘 | Delaney T P | 2001 | Mol Plant-Microbe Interact2001，14，： | 1 |
| 5 | Intrahepaticperipheral cholangiocarcinoma (IPCC) : comparison between perfusion ultrasound and CT imaging 显示文摘 | Donofrio M Vecchiato F Cantisani V | 2008 | Radiol Med2008，113，1： | 1 |
| 6 | Automated measurement ofred blood cell microcytosis and hypoehromia in iron deficiency andbeta-thalassemia trait显示文摘 | DONOFRIO G ZINI G RICERCA B M | 1992 | Arch Pathol Lab Med1992，116，1： | 1 |
| 7 | Combined interferon plus lamivudine treatment in young patients with dual HBV (HBeAg positive) and HCV chronic infection 显示文摘 | Marrone A Zampino R DOnofrio M | 2004 | J Hepatol2004，41，： | 1 |
| 8 | Fat distribution;a morphologic study of the aging face显示文摘 | DONOFRIO L M | 2000 | Dermatol Surg2000，26，12： | 1 |
| 9 | Acoustic radiation force impulse(AFRI)technique in ultrasound with virtual touch tissue quantification of upper abdomen显示文摘 | Gallotti A Donofrio M Pozzi Mucelli R | | 0，，： | 1 |
| 10 | Management of fatigue in patients with cancer-a practical overview 显示文摘 | Koornstra RIt Peters M Donofrio S | 2014 | Cancer Treat Rev2014，40，6： | 1 |
| 11 | Hypoxia-indueible faetor (HIF)- I alpha suppressicm in myel~ana cells Blocks tumoral growth in viw~ inhibiting angiogenesis and Bone destruction显示文摘 | Storti P Bolzoni M Donofrio G | 2013 | Leukemia2013，27，： | 1 |
| 12 | Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in Arabidopsis显示文摘 | Rairdan G J Donofrio N M Delaney T P | 2001 | MPMI2001，14，10： | 1 |
| 13 | Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection显示文摘 | Boonnak K Dambach K M Donofrio G C | 2011 | J Virol2011，85，： | 1 |
| 14 | Congenital complete heartblock:fetal management protocol,review of the literature,and report of the smallest successful pacemaker implantation显示文摘 | DONOFRIO M T GULLQUIST S D MEHTA I D | 2004 | J perinatol2004，24，： | 1 |
| 15 | Management of fatigue in patients with cancer-a practice overview显示文摘 | Koornstra R H Peters M Donofrio S | 2014 | Cancer Treat Rev2014，40，6： | 1 |
| 16 | Tissue quantification with acoustic radiation force impulse imaging: measurement repeatability and normal values in the healthy liver 显示文摘 | Donofrio M Gallotti A Mucelli RP | 2010 | AJR Am J Roentgenol2010，195，1： | 1 |
| 17 | In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction 显示文摘 | LAGOSTENA L ROSATO-SIRI M DONOFRIO M | 2010 | The Journal of neumscience2010，30，3： | 1 |
| 18 | Panfacial volume restoration with fat显示文摘 | Donofrio L M | 2005 | Dermatol Surg2005，31，2： | 1 |
| 19 | Presentation and surgical results of incidentally discovered nonfunctioning pituitary adenomas : evidence for a better outcome independently of other patients' characteristics显示文摘 | Losa M Donofrio CA Barzaghi R | 2013 | Eur J Endocrinol2013，169，6： | 1 |
| 20 | Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea 显示文摘 | Donofrio N M Oh Y Lundy R | 2006 | Fungal Genetics and Biology2006，43，9： | 1 |
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