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| 1 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 4 | Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation显示文摘 | Murray J A Kiran D K A Dominic P G | 2009 | Thrombosis Research2009，124，6： | 1 |
| 5 | Structure of biologically active muramyl peptides from peptidoglycan of Streptococcum Sanguis显示文摘 | SARKA B DOMINIC M D MICHAEL J P | 1998 | J Mass Spectrom1998，33，： | 1 |
| 6 | Cognitive therapy for bipolar illness-a pilot study of relapse prevention显示文摘 | Dominic H Bright J Steve J | 2000 | Cognitive Therapy and Research2000，24，5： | 1 |
| 7 | Surprisingly small HONO emissions from snow surfaces at Browning Pass, Antarctica 显示文摘 | Beine H J Amoroso A Domine F | 2006 | Atmos Chem Phys2006，6，： | 1 |
| 8 | Quantifying the relationship between co-expression,co-regulation and gene function显示文摘 | Dominic J A Isaac S K Atul J B | 2004 | BMC Bioinformatics2004，5，： | 1 |
| 9 | Fluxes of nitrates between snow surfaces and the atmosphere in the European high Arctic 显示文摘 | Beine H J Domine F lanniello A | 2003 | Atmos Chem Phys2003，3，： | 1 |
| 10 | Technical basis and proposal for deriving sediment quality criteria for metals显示文摘 | Gerald T A Dominic M D T David J H | 1996 | Environmental Toxicology and Chemistry1996，15，12： | 1 |
| 11 | Cloning of a human phosphoinositide 3-kinase with aC2 domain that displays reduced sensitivity to the inhibitor wotmannin显示文摘 | Domin J | 1997 | Biochem J1997，13，： | 1 |
| 12 | Comparison of BCF models based on log P显示文摘 | Devillers J Bintein S Domine D | 1996 | Chemosphere1996，33，6： | 1 |
| 13 | Snow-pile and chamber experiments during the Polar Sunrise Experiment 'Alert 2000': exploration of nitrogen chemistry 显示文摘 | Beine H J Domine F Simpson W | 2002 | Atmos Environ2002，36，： | 1 |
| 14 | High reliability and efficiency single-phase transformerless inverter for grid-connected photovoltaic systems 显示文摘 | GU B DOMINIC J LAI J S | 2013 | IEEE Trans Power Electron2013，8，5： | 1 |
| 15 | Association between inflammation and cardiac geometry in chronic kidney disease: findings from the CRIC study显示文摘 | Gupta J Dominic EA Fink JC | 2015 | PLoS One2015，10，01： | 1 |
| 16 | Optical properties ofa retroreflecting sheet显示文摘 | Dominic C O Grahame E F David J E | 1999 | Applied Optics1999，38，19： | 1 |
| 17 | Real-time detection of influenza A virus using semiconductor nanophotonics显示文摘Modern miniaturization and the digitalization of characterization instruments greatly facilitate the diffusion of technological advances in new fields and generate innovative applications.The concept of a portable,inexpensive and semi-automated biosensing platform,or lab-on-a-chip,is a vision shared by many researchers and venture industries.Under this scope,we present a semiconductor monolithic integration approach to conduct surface plasmon resonance studies.This technology is already commonly used for biochemical characterization in pharmaceutical industries,but we have reduced the technological platform to a few nanometers in scale on a semiconductor chip.We evaluate the signal quality of this nanophotonic device using hyperspectral-imaging technology,and we compare its performance with that of a standard prism-based commercial system.Two standard biochemical agents are employed for this characterization study:bovine serum albumin and inactivated influenza A virus.Time resolutions of data acquisition varying between 360 and 2.2 s are presented,yielding 2.731025–1.531026 RIU resolutions,respectively. | Dominic Lepage Alvaro Jimenez Jacques Beauvais Jan J Dubowski | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 18 | An Open-label Trial of Evidence-Based Cognitive Behavior Therapy for Nightmares and Insomnia in Crime Victims With PTSD显示文摘 | Barry K Lisa J Dominic M | 2001 | Am J Psychia- try2001，158，12： | 1 |
| 19 | Use of CAD/CAM technology to fabricate a removable partial denture framework显示文摘 | Williams R J Bibb Richard Eggbeer Dominic | 2006 | The Journal of prosthetic dentistry2006，96，2： | 1 |
| 20 | Use of CAD/CAM technology to fabricate a removable partial den- ture Framework显示文摘 | Williams R J Richard Bibb Dominic Eggbeer | 2006 | The Journal of Prosthetic Dentistry2006，96，2： | 1 |
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