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111篇 您的检索式:作者名="DOMENICO P"
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1CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE.Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola 2015World Journal of Gastroenterology2015,21,9:2
2An Analytical Model for Multidimen-sional Transport of Decaying Contaminant Species显示文摘DOMENICO P A 1987Journal of Hydrology1987,91,12:1
3Cisplatin/Peme- trexed Followed by Maintenance Pemetrexed Versus Carbo platin/Paclitaxel/Bevacizumab Followed by Maintenance Bevacizumab in Advanced Nonsquamous Lung Cancer:The GOIM(GruppoOncoIogico Italia Meridionale)ERACLE Phase IS Randomized Trial显示文摘Domenico G Saverio C Salvatore P 2012Cancer Chemother Pharm- acol2012,70,2:1
4OS-alkylguanines, dietary N-nitroso compounds, and their precu-in gastric cancer显示文摘Domenico P Calogero S Claudio C 2001NutrCancer2001,39,1:1
5Noninvasive pressure support ventilation in immunocompromised children with ARDS:a feasibility study显示文摘Marco P Daniele DL Domenico P 2009Intensive Care Med2009,35,4:1
6Water from low-permeability sediments and land subsidence显示文摘Domenico P A Mifflin M D 1965Water Resources Research1965,1,4:1
7The effect of sodium salicylate on antibiotic susceptibility and synergy in Klebsiella pneumoniae 显示文摘Domenico P Hopkins T Cunha BA 1990J Antimicrob Chemother1990,26,:1
8Social Bricolage: Theoriz- ing Social Value Creation in Social Enterprises 显示文摘Di Domenico M Hangh H Tracey P 2010Entrepre- neurship Theory and Practice2010,34,4:1
9Social econ- omy involvemem in public service delivery:Community engag- ement and accountability显示文摘DOMENICO M D TRACEY P HUAUGH H 2009Regional Studies2009,43,7:1
10Thermal expansion of fluids and fracture initiation in compacting sediments 显示文摘Domenico P A Palciauskas V V 1979AAPG Bulletin1979,90,:1
11Review:antioxidants and endothelium protection显示文摘Domenico P 2005Atherosclerosis2005,181,2:1
12D - dimers are not al- ways elevated in patients with acute dissection 显示文摘Domenico P Pietro GM Giuseppe S 2009J Cardiovasc Med2009,10,2:1
13Contribution of corticospinal tract damage to cortical motor reorganization after a single clinical attack of multiple sclerosis显示文摘 Caterina M Domenico IG 2002Neuro Image2002,17,4:1
14Plasma and serum levels of D dimmer andtheir correlation with other haemostatic parameters in pregnancy显示文摘 Domenico P Bandinelli B 2002Thromb Res2002,105,:1
15In vitro activity and synergy of bismuth thiols and tobramycin against Burkholderia cepacia complex显示文摘Veloira W G Domenico P LiPuma J J 2003J Antimicrob Chemother2003,52,:1
16Sleep deprivation impairs memory,tau metabolism,and synaptic integrity of a mouse model of Alzheimer’s disease with plaques and tangles显示文摘Antonio DM Yash BJ Domenico P 2014Neurobiology of Aging2014,35,8:1
17The incidence ofchromosomal anomalies in fetuses affected by mild renal pyelectasis显示文摘Borrelli AL Borrelli P Di Domenico A 2004Minerva Ginecol2004,56,2:1
18Surface complexation modeling of phosphate adsorption by water treatment residual显示文摘Michael A B Domenico G Cristian P 1998Journal of Environmental Quality1998,27,:1
19Growth of AIN piezoelectric film on diamond for high-frequency surface acoustic wave devices 显示文摘Massimiliano B Domenico C Fabio D P 2005IEEE Trans UFFC2005,52,10:1
20Cytokines and cell Adhesion Molecules in Cerebral Isehemia 显示文摘Leonardo P Cristina S Domenico I 1998Arteriosclerosis Thrornbosis andVascular Biology1998,18,:1
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