|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 2 | Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections显示文摘 | Xiaoyong Zhang Anke Kraft Ruth Broering Joerg F Schlaak Ulf Dittmer Mengji Lu | 2012 | Expert Opinion on Drug Discovery2012，，7： | 3 |
| 3 | A prospective study of central venous hemodialysis catheter colonization and peripheral bacteremia显示文摘 | Dittmer ID Sharp D McNulty CA | 1999 | Clin Nephrol1999，51，： | 1 |
| 4 | 显示文摘 | Huynh W U Dittmer J J Alivisatos A P | 2002 | Science2002，295，： | 1 |
| 5 | Hybrid nanorod-polymer solar cells 显示文摘 | Huynh W U Dittmer J J Alivisatos A P | 2002 | Science2002，295，： | 1 |
| 6 | Functional impairment of CDS( + ) T cells by regulatory T cells during persistent retroviral infection显示文摘 | Dittmer U He H Messer R J | 2004 | Immunity2004，20，： | 1 |
| 7 | Hybrid nanorod-polymer solar cells 显示文摘 | Huynh W U Dittmer J J Alivisatos A P | 2002 | Science (S0036-8075)2002，295，： | 1 |
| 8 | Biological Weapons and International Law 显示文摘 | Huynh W U Dittmer J J Alivisatos A P | 2002 | Science2002，295，5564： | 1 |
| 9 | 显示文摘 | Huynh W U Dittmer J J Alivisatos A P | 2002 | Science2002，295，： | 1 |
| 10 | Liposomal daunorubicin as treatment for Kaposi's sarcoma 显示文摘 | PETRE CE DITTMER DP | 2007 | Int J Nanomedicine2007，2，3： | 1 |
| 11 | Multiple organ failure in polytrauma patients 显示文摘 | Faist E Baue AE Dittmer H | 1983 | J Trauma1983，23，： | 1 |
| 12 | Subungual exotosis of the finger: case report and review of the literature显示文摘 | Ward CM Dittmer A | 2013 | Iowa Orthop J2013，33，： | 1 |
| 13 | HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance显示文摘To the Editor It is believed that the inherent tolerogenic property of the liver is involved in the chronicity of hepatitis B virus(HBV)infection[1].However,exposure to HBV in adults usually leads to spontaneous clearance of the virus and the induction of potent and effective anti-HBV T cell immunity in the liver[2],suggesting that the immune microenvironment of the liver switches from limiting to allowing effector T cell responses during acute resolution of HBV infection. | Xiaohong Xie Jinzhuo Luo Ruth Broering Dan Zhu Wenqing Zhou Mengji Lu Xin Zheng Ulf Dittmer Dongliang Yang Jia Liu | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 14 | AnovelnonsensemutationinheDMP1geneidentifiedbyagenome-wideassociationstudyisresponsibleforinheritedricketsin Corriedalesheep显示文摘 | ZHAO X DITTMER K E BLAIR H T etal | 2011 | PLoSOne2011，6，21： | 1 |
| 15 | Beta-Actin is not a reliable loading control in Western blot analysis显示文摘 | DITFMER A DITTMER J | 2006 | Electrophoresis2006，27，14： | 1 |
| 16 | Hy-brid nanorod-polymer solar cells 显示文摘 | HUYNH W U DITTMER J J ALIVISATOS A P | 2002 | Science2002，295，： | 1 |
| 17 | A polymorphic microsatellite that mediates induction of PIG3 by p53 显示文摘 | Contente A Dittmer A Koch MC | 2002 | Nat Genet2002，30，3： | 1 |
| 18 | Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma associated herpesvirus显示文摘 | Wang L Dittmer DP Tomlinson CC | 2006 | Cancer Res2006，66，： | 1 |
| 19 | Characterization of endogenous and recombinant forms of laccase-2, a muhicopper oxidase from the tobacco homworm, Manduca sexta 显示文摘 | Dittmer N T Gorman M J Kanost M R | 2009 | Insect Biochem Mol Biol2009，39，9： | 1 |
| 20 | Hybrid nanorod-polymer solar cells显示文摘 | HUYNH W U DITTMER J J ALIVISATOS A P | 2002 | Science2002，295，5564： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员