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| 1 | Histopathology of nonalcoholic fatty liver disease显示文摘Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease(NAFLD) are measured.Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,i.e.nonalcoholic steatohepatitis(NASH) and fibrosis.Included in the lesions of NAFLD are steatosis,lobular and portal inflammation,hepatocyte injury in the forms of ballooning and apoptosis,and fibrosis.However,patterns of these lesions are as distinguishing as the lesions themselves.Liver injury in adults and children due to NAFLD may have different histological patterns.In this review,the rationale for liver biopsy,as well as the histopathological lesions,the microscopically observable patterns of injury,and the differential diagnoses of NAFLD and NASH are discussed. | Elizabeth M Brunt Dina G Tiniakos | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | E2F transcription factors and digestive system malignancies: How much do we know?显示文摘E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric and colorectal adenocarcinoma, and in hepatocellular carcinoma (HCC), whereas in pancreatic ductal adenocarcinoma and esophageal squamous cell carcinoma may function as a tumorpromoter. In the latter malignancies, E2F1 immunohistochemical expression has been correlated with higher tumor grade and worse patient survival, whereas in esophageal, gastric and colorectal adenocarcinomas is a marker of increased patient survival. E2F2 has only been studied in colorectal cancer, where its role is not considered significant. E2F4's role in colorectal, gastric and hepatic carcinogenesis is tumor-promoting. E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies. Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. Further understanding of E2Fs' contribution in cellular functions in vivo would help clarify their role in carcinogenesis. | Athanasios Xanthoulis Dina G Tiniakos | 2013 | World Journal of Gastroenterology2013，19，21： | 10 |
| 3 | Liver histology in ICU patients dying from sepsis:A clinico-pathological study显示文摘AIM:To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit. METHODS: Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded. RESULTS: Liver biochemistries were increased in the majority of patients before death. Histology of liver bi- opsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholan- gitis/cholangiolitis in 20% of patients. Mixed hepatitic/ cholestatic type of liver injury was observed in 6/15 (40%) patients and hepatitc in 9/15 (60%). Steatosis was ob- served in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was as- sociated with increased hospitalization in the ICU prior death (P = 0.026). CONCLUSION: Features of hepatitis and steatosis arethe main histological findings in the liver in the majority of patients dying from sepsis. | John Koskinas Ilias P Gomatos Dina G Tiniakos Nikolaos Memos Maria Boutsikou Aspasia Garatzioti Athanasios Archimandritis Alexander Betrosian | 2008 | World Journal of Gastroenterology2008，14，9： | 8 |
| 4 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs 显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，20： | 1 |
| 5 | Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage 显示文摘 | Triolo D Dina G Lorenzetti I | 2006 | J Cell Sci2006，119，19： | 1 |
| 6 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，20： | 1 |
| 7 | Jabl regulates Schwann cell proliferation and axonal sorting through p27显示文摘 | PORRELLO E RIVELLINI C DINA G | 2014 | J Exp Med2014，211，1： | 1 |
| 8 | Increased in vivo expression and production endothelin-1 by porcine cardiomyocytes subjected to ischemia显示文摘 | Theis T Adel G Dina S | 1995 | Circ Res1995，76，： | 1 |
| 9 | Design and study of piracetam - like nootropics, controversial members of the pmblenmtic class of cognition- enhancing drugs 显示文摘 | Fulvio G Dina M Maria NR | 2002 | Current Pharmaeeutical Design2002，8，2： | 1 |
| 10 | Transanal endoscopic microsurgery:experience with 75 rectal neoplasms显示文摘 | Dina LC David M Gideon G | | 0，，： | 1 |
| 11 | Vimentin regulates peripheral nerve myelination显示文摘 | Triolo D Dina G Taveggia C | 2012 | Development2012，139，： | 1 |
| 12 | Measles in France显示文摘 | Mortamet G Dina J Freymuth F | 2012 | Arch Pediatr2012，19，： | 1 |
| 13 | An Affordance-based Approach to Architectural Theory, Design, and Practice显示文摘 | MAIER Jonathan R A FADEL Georges M BATTISTO Dina G | 2009 | Design Studies2009，30，4： | 1 |
| 14 | Knowledge and practice of contraception among Greek female medical students 显示文摘 | Dinas K Hatzipantelis E Mavromatidis G | 2007 | Eur J Contracept Reprod Health Care2007，8，： | 1 |
| 15 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，： | 1 |
| 16 | Design and study of piracetam-like nootropics,controve-rsial members of the problematic of congnition-enhancing drugs显示文摘 | Fulvio G Dina M Maria N R | 2002 | Current Pharmaceutical Design2002，8，2： | 1 |
| 17 | Measles in France显示文摘 | Mortamet G Dina J Freymuth F | 2012 | Arch Pediatr2012，19，1： | 1 |
| 18 | Loss of glial fibril- lary acidic protein(GFAP) impairs Schwann cell prolifer- ation and delays nerve regeneration after damage 显示文摘 | Triolo D Dina G Lorenzetti I | 2006 | J Cell Sci2006，119，19： | 1 |
| 19 | Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis显示文摘 | Pluehinn S Quattrini A Brambilla E Gritti A Salani G Dina G | 2003 | Nature2003，422，6933： | 1 |
| 20 | Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5ql 1-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes显示文摘 | Barat-Houari M Clement K Vatin V Dina C Bonhomme G Vasseur F etal | 2002 | Diabetes2002，51，5： | 1 |
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