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| 1 | Lipidomics in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD),the most common chronic liver disorder in Western countries,comprises steatosis to nonalcoholic steatohepatitis(NASH),with the latter having the potential to progress to cirrhosis.The transition from isolated steatosis to NASH is still poorly understood,but lipidomics approach revealed that the hepatic lipidome is extensively altered in the setting of steatosis and steatohepatitis and these alterations correlate with disease progression.Recent data suggest that both quantity and quality of the accumulated lipids are involved in pathogenesis of NAFLD.Changes in glycerophospholipid,sphingolipid,and fatty acid composition have been described in both liver biopsies and plasma of patients with NAFLD,implicating that specific lipid species are involved in oxidative stress,inflammation,and cell death.In this article,we summarize the findings of main human lipidomics studies in NAFLD and delineate the currently available information on the pathogenetic role of each lipid class in lipotoxicity and disease progression. | Sofia Kartsoli Christina E Kostara Vasilis Tsimihodimos Eleni T Bairaktari Dimitrios K Christodoulou | 2020 | World Journal of Hepatology2020，12，8： | 5 |
| 2 | Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths:An ecological integrative approach显示文摘BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019(COVID-19)pandemic.Αsignificant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown,while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status.Low serum 25-hydroxyvitamin-D[25(OH)D]was identified as an independent risk factor for COVID-19 infection and hospitalization,and administration of 0.532 mg(21280 IU)of calcifediol or 25(OH)D,followed by 0.266 mg on days 3 and 7 and then weekly until discharge or intensive care unit admission significantly reduced the need for intensive care unit treatment.AIM To elucidate the role of vitamin D European population status in the COVID-19 pandemic,data from the Worldometer were analyzed.METHODS Linear regression explored the correlation between published representativestandardized population vitamin D concentrations and the number of total cases/million(M),recovered/M,deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated>4 M(Worldometer).Life expectancy was analyzed with semi-parametric regression.Weighted analysis of variance/analysis of covariance evaluated serious-critical/M and deaths/M by the vitamin D population status:Deficient<50,insufficient:50-62.5,mildly insufficient>62.5-75 and sufficient>75 nmol/L,while controlling for life expectancy for deaths/M.Statistical analyses were performed in XLSTAT LIFE SCIENCE and R(SemiPar Library).RESULTS Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M,but negative correlations predicting a reduction of 47%-64%-80%in serious-critical illnesses/M and of 61%-82%-102.4%in deaths/M further enhanced when adapting for life expectancy by 133-177-221%if 25(OH)D concentrations reach 100-125-150 nmol/L,sustained on August 15,2020,indicating a truthful association.Weighted analysis of variance was performed to evaluate serious-critical/M(r2=0.22)by the vitamin D population status and analysis of covariance the deaths/M(r2=0.629)controlling for life expectancy(r2=0.47).Serious-critical showed a decreasing trend(P<0.001)from population status deficient(P<0.001)to insufficient by 9.2%(P<0.001),to mildly insufficient by 47.6%(P<0.044)and to sufficient by 100%(reference,P<0.001).For deaths/M the respective decreasing trend(P<0.001)was 62.9%from deficient(P<0.001)to insufficient(P<0.001),65.15%to mildly insufficient(P<0.001)and 78.8%to sufficient(P=0.041).CONCLUSION Achieving serum 25(OH)D 100-150 nmol/L(40-60 ng/mL)(upper tolerable daily doses followed by maintenance proposed doses not requiring medical supervision,Endocrine Society)may protect from serious-critical illness/death from COVID-19 disease. | Dimitrios T Papadimitriou Alexandros K Vassaras Michael F Holick | 2021 | World Journal of Virology2021，10，3： | 2 |
| 3 | Firework-related childhoodinjuries in Greece : a national problem 显示文摘 | Vassilia K Eleni P Dimitrios T | 2004 | Burns2004，30，2： | 1 |
| 4 | Breast cancerfollowing diethylstilbestrol exposure in utero: insights from a tragedy显示文摘 | Hans O A Pagona L Dimitrios T | 2012 | European Journal of Epidemiology2012，27，1： | 1 |
| 5 | On the singularities of the gravity field of a homogeneous polyhedral body显示文摘 | DIMITRIOS T SVETO P | 2001 | Geophysics2001，66，2： | 1 |
| 6 | Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression 显示文摘 | Dimitrios T Vassiliki A B | 2009 | Cell Cycle2009，8，： | 1 |
| 7 | Breast cancer following diethylstilbestrol exposure in utero: insights from a tragedy 显示文摘 | Hanso A Pagona L Dimitrios T | 2012 | European Joumal of Epidemiology2012，27，1： | 1 |
| 8 | Effects ofheat treatment on atmospheric composition and color of peeled whiteasparagus in modified atmosphere packaging显示文摘 | ANASTASIOS S S DIMITRIOS G B PAVLOS T A | 2010 | Innovative FoodScience and Emerging Technologies2010，11，1： | 1 |
| 9 | Laparoscopic resection of an adrenal schwannoma显示文摘 | Konstantinos T G Dimitrios T Panagiotis K B | 2012 | JSLS2012，16，4： | 1 |
| 10 | Galen on syncope显示文摘 | Niki P Dimitrios T | 2010 | Int J Cardiol2010，142，3： | 1 |
| 11 | Soluble Carbon Nanotubes显示文摘 | Dimitrios T N | 2003 | Chemistry- A European Journal2003，9，17： | 1 |
| 12 | Combination docetaxel(Taxotere),flurouracil,and leucovorin(TFL),as first-line chemotheraphy in advanced gastric cancer:a Hellnic Cooperative Oncology Group phase Ⅱ study显示文摘 | Pavlos P Dimitrios T Paris K | 2006 | Gastric Cancer2006，9，1： | 1 |
| 13 | Anastomotic leakage after low anterior resection for rectal cancer:faels,oseurity,and fiction 显示文摘 | Panagiotis T Manousos C Dimitrios DT | 2009 | Surg Today2009，39，2： | 1 |
| 14 | Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs:Three case reports and a literature review显示文摘BACKGROUND Alopecia areata(AA)is an inflammatory disease with autoimmune,environmental,and inherited components directed at the hair follicle,either limited to patchy hair loss over the scalp(Focalis,AF),total loss of scalp hair(Totalis,AT),or total loss of both scalp and body hair(Universalis,AU).Despite multiple treatment modalities,no therapy exists.Vitamin D deficiency in patients with AA/AT/AF influences disease severity and duration,inversely correlating with inflammation histologically.CASE SUMMARY Three girls presented with AT(P1),AU(P2),and AF(P3)at the ages of 1,5,and 5 years,respectively.For P1-P2,all available treatments implemented for 2 years had failed.We started an initial 6-mo repletion with oral cholecalciferol 2000/4000 IU/d,with no apparent effect.Then we attempted immunomodulation using oral calcitriol and its analog paricalcitol.On calcitriol,0.5 mcg/d P1 regrew hair within 6 mo.After 4 years,a relapse with loss of eyebrow hair was resolved after doubling the calcitriol dose to 0.5 mcg×2/d;the results have been maintained for 6 years to date.On calcitriol,0.25 mcg×3/d P2 led to the development of asymptomatic hypercalcemia-hypercalciuria,which was immediately resolved by switching to paricalcitol 2 mcg×3/d;mild tolerable hypercalciuria was maintained.Hair regrowth was observed at 6 mo,stabilizing only as fur at 12 mo.AF in P3 was resolved completely within 3 mo on a daily high dose(8000 IU)of cholecalciferol.CONCLUSION Vitamin D may have immunomodulating therapeutic impact on AT/AU/AF,which needs to be explored with further pilot clinical trials. | Dimitrios T Papadimitriou Christina Bothou Eleni Dermitzaki Alexios Alexopoulos George Mastorakos | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 1 |
| 15 | Introducing competition in healthcare services: the role of private care and increased patient mobility 显示文摘 | Dimitrios A A Christopher S T | 2014 | European Journal of Operational Research2014，23，4： | 1 |
| 16 | Sychronou sanorectal malignant melanoma andrectal adenocarcinoma显示文摘 | Panagiotis D Dimitrios K George T | 1997 | Dis Colon Rectum1997，40，1： | 1 |
| 17 | Prediction of marine diesel engine performance under fault conditions显示文摘 | Hountalas Dimitrios T | 2000 | Applied Thermal Engineering2000，20，12： | 1 |
| 18 | Simple one-step synthesis of 3-bromoand 3,8-dibromo-1,10-phenanthroline:fundamental building blocks in the design of metal chelates tetrahedron letters显示文摘 | YITZHAT T SALVAT1ORRE F | 1995 | 36(20):3489-34901995，36，20： | 1 |
| 19 | Carbon nanotube polymer composites: Chemistry, processing, mechanicaland electrical properties 显示文摘 | Zdenko S S Dimitrios T Konstantinos P P | 2010 | Progress in Polymer Science2010，35，： | 1 |
| 20 | Comparison of ISO- GUM and Monte Carlo methods for the evaluation of measurement uncertainty: Application to direct cadmium measurement in water byGFAAS 显示文摘 | Dimitrios T Loukia M Sotirios K | 2011 | Talanta2011，83，5： | 1 |
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