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| 1 | 新辅助免疫治疗可以为MMR表达以及MMR缺失型早期结肠癌患者带来病理缓解显示文摘PD-1联合CTLA-4阻滞剂对晚期错配修复蛋白(MMR)缺失(dMMR)型结直肠癌患者的治疗非常有效,但对MMR表达(pMMR)的患者无效。我们假设在早期结肠癌患者中新辅助免疫疗法具有更好的疗效。在探索性NICHE研究中(Clinical Trials.gov:NCT03026140),dMMR或pMMR患者在手术前接受单剂量伊匹单抗(ipilimumab)和两剂量纳武单抗(nivolumab)治疗,pMMR患者联合或者不联合使用塞来昔布。本研究的主要观察指标是安全性和可行性。在纳入分析的40例患者中,包括21例dMMR患者和19例pMMR患者,他们均接受了治疗,其中3例经安全性讨论后仅接受了纳武单抗单药治疗。患者治疗耐受性良好,所有患者均接受了根治性切除且未延期进行,符合主要观察指标的观察预期。在接受伊匹单抗+纳武单抗治疗的患者(20例dMMR患者和15例pMMR患者)中,共35例可进行疗效和转化效果评估。在20例dMMR患者中,病理缓解率为100%(95%CI:86%~100%),有19例患者达到主要病理缓解(MPRs,残留存活肿瘤≤10%),其中包括12例患者达到完全病理缓解。在15例pMMR患者中,有4例达到病理缓解,其中包括3例主要病理缓解和1例部分缓解。CD8+PD-1+T细胞浸润情况可预测pMMR患者的治疗应答。基于这些数据认为,如果新辅助免疫治疗效果能被基于至少3年无病生存数据的更加大型的临床研究结果支持,那么其则有望作为特定结肠癌患者的标准治疗方案。 | 张荣欣 CHALABI M FANCHI L F DIJKSTRA K K | 2020 | 结直肠肛门外科2020，26，6： | 87 |
| 2 | TME术前短程放疗后化疗对比术前放化疗联合术后辅助化疗治疗局部晚期直肠癌(RAPIDO研究)—一项随机、开放的Ⅲ期临床试验显示文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。 | 李来元 张维胜 BAHADOER R R DIJKSTRA E A VAN ETTEN B | 2021 | 结直肠肛门外科2021，27，1： | 72 |
| 3 | 结合硬斑块特征的心血管内超声图像中-外膜边缘检测显示文摘针对心血管内超声(IVUS)图像中-外膜(media-adventitia)边缘检测中,硬斑块和声影等造成中-外膜边缘难以准确检测的问题,提出一种结合硬斑块特征的中-外膜边缘检测方法。首先,采用k均值聚类分割IVUS图像,根据图像中不同类型斑块的成像特点检测硬斑块位置;然后,计算IVUS图像方向梯度,结合斑块位置和图像灰度,获得代价矩阵;最后,利用启发式图搜索方法,实现IVUS图像的中-外膜边缘检测。对临床图像的实验结果表明,本方法能克服图像中声影和斑块干扰等问题,使检测正确率达到95.57%,提高了IVUS图像中-外膜边缘检测的准确性。 | 邢栋 杨丰 黄靖 涂圣贤 DIJKSTRA Jouke | 2012 | 中国生物医学工程学报2012，31，1： | 7 |
| 4 | Deformation of the Zhangjiazhuang high-speed railway tunnel: an analysis of causal mechanisms using geomorphological surveys and D-InSAR monitoring显示文摘On 18 January 2016,the Zhangjiazhuang high-speed railway tunnel in Ledu,Qinghai Province,China,underwent serious deformation and structural damage.A crack formed at the top of the tunnel and the concrete on the crown peeled off.As a result,the tunnel could not be operated for three months.In order to determine the types and spatial distribution of the landslides in the region and the surface deformation characteristics associated with the tunnel deformation,we used field geological and geomorphological surveys,unmanned aerial vehicle image interpretation and differential interferometric synthetic aperture radar(D-In SAR) surface deformation monitoring.Nine ancient and old landslides were identified and analysed in the study area.Surface deformation monitoring and investigation of buildings in several villages on the slope front showed that the tunnel deformation was not related to deep-seated gravitational slope deformation.However,surface deformation monitoring revealed an active NEE–SWW fault in the area intersecting the tunnel at the location of the tunnel rupture.This constitutes a plausible mechanism for the deformation of the tunnel.Our study highlights the need for detailed engineering geomorphological investigations to better predict the occurrence of tunnel deformation events in the future. | MENG Xing-min QI Tian-jun ZHAO Yan DIJKSTRA Tom SHI Wei LUO Yin-fei WU Yuan-zhao SU Xiao-jun ZHAO Fu-meng MA Jin-hui ZHANG Yi CHEN Guan YUE Dong-xia ZHANG Mao-sheng | 2021 | Journal of Mountain Science2021，18，7： | 5 |
| 5 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 6 | A note on two problems in connexion with graphs显示文摘 | E. W. Dijkstra | 1959 | Numerische Mathematik1959，，1： | 4 |
| 7 | Big earth data analytics on Sentinel-1 and Landsat imagery in support to global human settlements mapping显示文摘Continuous global-scale mapping of human settlements in the service of international agreements calls for massive volume of multi-source,multi-temporal,and multi-scale earth observation data.In this paper,the latest developments in terms of processing big earth observation data for the purpose of improving the Global Human Settlement Layer(GHSL)data are presented.Two experiments with Sentinel-1 and Landsat data collections were run leveraging on the Joint Research Centre Earth Observation Data and Processing Platform.A comparative analysis of the results of built-up areas extraction from different remote sensing data and processing workflows shows how the information production supported by data-intensive computing infrastructure for optimization and multiple testing can improve the output information reliability and consistency within the GHSL scope.The paper presents the processing workflows and the results of the two main experiments,giving insights into the enhanced mapping capabilities gained by analyzing Sentinel-1 and Landsat data-sets,and the lessons learnt in terms of handling and processing big earth observation data. | Christina Corbane Martino Pesaresi Panagiotis Politis Vasileios Syrris Aneta JFlorczyk Pierre Soille Luca Maffenini Armin Burger Veselin Vasilev Dario Rodriguez Filip Sabo Lewis Dijkstra Thomas Kemper | 2017 | Big Earth Data2017，1，1： | 3 |
| 8 | Resolution of phylogenetic relationships of the major subfamilies of the Delphacidae (Homoptera: Fulgoroidea) using the mitochondrial ribosomal DNA显示文摘到亚科的从类水平的 Delphacid 关系完全被解决了(在那些之中征税一检验) 用从 12S 的 3'' 结束的顺序数据, gene.Monophyly, non-asiracine,亚科强烈被支持, asiracine Ugyops 被放在最树的基础位置。支持层次为 monophyly 在 weighting transversions 以后的 Delphaciniincreased 更重重地比转变并且在把 cixiidoutgroup 从数据集移开以后。在 Delphacini 之中, Conomelus 和 Megamelus 比也到过 Chloriona 与对方有关仔细是更多。这些结果基于词法人物与树一致。然而,与词法数据相对照我们的结果强烈在之间的 supportedasister 组关系 Stenocraninae 和 Kelisiinae。尽管 12S 基因碎片在 Chloriona 以内关于种类关系给了一些信息,既不这碎片也不 16S 基因的 5'' 结束看起来为这水平很有用。Molecularevolutionary 模式提供了在从 T 的基础作文有移动到 Aduring 的证据 non-Asiracinae 的早进化。non-Asiracinae 也有比较地快的替换率,这二观察可能被相关。在“现代”的 delphacidChloriona, AT 内容在没有限制的区域是比较地低的,但是这为“非现代”的 delphacids 不是事实。为缬氨酸的 tRNA 是在其它地方的 translocated,可能从对方在 Delphacidae 和 Cixiidae 前分叉。 | EDDY DIJKSTRA MICHEL A. SLOTMAN RORY J. POST | 2006 | Insect Science2006，13，3： | 3 |
| 9 | Establishment of Withania somnifera Hairy Root Cultures for the Production of Withanolide A显示文摘Withania sominifera (Indian ginseng) was transformed by Agrobacterium rhizogenes. Explants from seedling roots, stems, hypocotyls, cotyledonary nodal segments, cotyledons and young leaves were inoculated with A. rhizogenes strain R1601. Hairy (transformed) roots were induced from cotyledons and leaf explants. The transgenic status of hairy roots was confirmed by polymerase chain reaction using nptII and rolB specific primers and, subsequently, by Southern analysis for the presence of nptII and rolB genes in the genomes of transformed roots. Four clones of hairy roots were established; these differed in their morphology. The doubling time of faster growing cultures was 8-14 d with a fivefold increase in biomass after 28 d compared with cultured, non-transformed seedling roots. MS-based liquid medium was superior for the growth of transformed roots compared with other culture media evaluated (SH, LS and N6), with MS-based medium supplemented with 40 g/L sucrose being optimal for biomass production. Cultured hairy roots synthesized withanolide A, a steroidal lactone of medicinal and therapeutic value. The concentration of withanolide A in transformed roots (157.4 μg/g dry weight) was 2.7-fold more than in non-transformed cultured roots (57.9 μg/g dry weight). | Hosakatte N. Murthy Camelia Dijkstra Paul Anthony Daniel A. White Mike R. Davey J. Brian Power Eun J. Hahn Kee Y. Paek | 2008 | Journal of Integrative Plant Biology2008，50，8： | 3 |
| 10 | 青贮饲料中接种乳酸菌对黑白花奶牛甲烷排放和生产性能的影响显示文摘乳酸菌菌剂(LAB)通过增加青贮饲料中乳酸和其他有机酸类含量、降低饲料p H来提高饲料品质,防止酸败。本试验在青贮饲料中添加LAB,改变青贮饲料品质及其在瘤胃中的发酵条件,探索饲料中添加LAB对奶牛干物质采食量(DMI)、消化率、产奶量、牛奶品质和甲烷(CH4)排放量的影响。8头泌乳中期荷斯坦-黑白花杂交奶牛根据产奶量分成高产和低产两组,采用4×4拉丁方阵设计21 d试验。CH_4排放量采用间接量热法测量。各组青贮饲料(主要成分为黑麦草)分为空白组、长期添加LAB组、短期添加组(饲喂前16 h添加)和长短期综合添加组。所有饲料都由牧草青贮和复合物构成(干物质基础上的比例为7525)。长期添加组菌剂中植物乳杆菌、乳酸乳球菌和布氏乳杆菌比例为102070,短期添加组为乳酸乳球菌。试验结果表明,长期添加组和短期添加组对奶牛干物质摄入量(DMI)、中性洗涤纤维(NDF)、脂肪消化率、氮含量和能量平衡无显著影响,对乳成分(尤其是尿素)、乳脂肪、乳蛋白质和牛奶中微生物总数均无显著影响。但长期添加LAB使产奶量有增加趋势。长期添加组和短期添加组的奶牛中CH_4排放量无显著变化。其中,长期添加组中以k J·kg^(-1)为单位的代谢体重有提高趋势。试验结果得出引起动物生产性能改变的LAB最小添加量,包括长期和短期的。虽然其他研究表明青贮饲料中添加菌剂能对奶牛生产性能产生有利的显著影响,但本试验由于剂量、青贮饲料基底牧草选择和保存条件等因素的差异,未产生显著影响。 | Ellis J L Hindrichsen I K Klop G Kinley R D Milora N Bannink A Dijkstra J | 2016 | 饲料博览2016，0，9： | 3 |
| 11 | Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering显示文摘 | Liliana S. Moreira Teixeira Jan Feijen Clemens A. van Blitterswijk Pieter J. Dijkstra Marcel Karperien | 2011 | Biomaterials2011，，5： | 2 |
| 12 | 显示文摘 | Marius Vaarkamp Willem Dijkstra Bennie H Reesink | 2001 | Catalysis Today2001，69，： | 2 |
| 13 | The Intravertebral Cleft in Painful Long-Standing Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Vertebroplasty: Diagnostic Assessment and Clinical Significance显示文摘 | Marc J. Nieuwenhuijse Carla S. P. van Rijswijk Arian R. van Erkel Sander P. D. Dijkstra | 2012 | Spine2012，，11： | 2 |
| 14 | A test of genetic association among male nuptial coloration, female mating preference, and male aggression bias within a polymorphic population of cichlid fish显示文摘 | Inke van der SLUIJS Peter D. DIJKSTRA Charlotte M. LINDEYER BertanneVISSER Alan M. SMITH Ton G. G. GROOTHUIS Jacques J. M. van ALPHEN Ole SEEHAUSEN | 2013 | Current Zoology2013，59，2： | 2 |
| 15 | Postoperative cognitive dysfunction versus complaints:a discrepancy in long-term findings 显示文摘 | Dijkstra JB Jolles J | 2002 | Neuropsychol Rev2002，12，1： | 2 |
| 16 | How does male-male competition generate negative frequency-dependent selection and disruptive selection during speciation?显示文摘 | Peter D. DIJKSTRA Shana E. BORDER | 2018 | Current Zoology2018，64，1： | 2 |
| 17 | Two problems in connection with graphs显示文摘 | Dijkstra E | 1959 | Numerische Mathematik1959，1，5： | 2 |
| 18 | In vitro degradation of dermal sheep collagen cross-linked using a water-soluble carbodiimide显示文摘 | L.H.H.Olde Damink P.J. Dijkstra M.J.A. van Luyn P.B. van Wachem P. Nieuwenhuis J. Feijen | 1996 | Biomaterials1996，，7： | 2 |
| 19 | High-gain waveguide amplifiers in SigN4 technology via double-layer monolithic integration显示文摘Silicon nitride(SiN)-on-SiO,attracts increasing interest in integrated photonics owing to its low propagation loss and wide transparency window,extending from^400 nm to 2350 nm.Scalable integration of active devices such as amplifiers and lasers on the Si;N,platform will enable applications requiring optical gain and a much-nceded alternative to hybrid integration,which suffers from high cost and lack of high-volume manufacturability.We demonstrate a high-gain optical amplifier in Al2O3:Er^3+ monolithically integrated on the Si3N4 platform using a double photonic layer approach.The device exhibits a net Si3N4-to-Si3N4 gain of 18.11±0.9 dB at 1532 nm,and a broadband gain operation over 70 nm covering wavelengths in the S-,C-and L-bands.This work shows that rare-carth-ion-doped materials and in particular,rare-earth-ion-doped Al.05,can provide very high net amplification for the Si3N4 platform,paving the way to the development of different active devices monolithically integrated in this passive platform. | JINFENG MU MEINDERT DIJKSTRA JEROEN KORTERIK HERMAN OFFERHAUS ANDSONIA M.GARCIA-BLANCO | 2020 | Photonics Research2020，8，10： | 2 |
| 20 | A note on two problems in connection with graphs显示文摘 | Dijkstra E W | 1959 | Numerische Mathematik1959，1，1： | 1 |
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