|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Behavior of noncircular tunnels excavated in stratified rock masses-Case of underground coal mines显示文摘The amount of tunnels excavated along stratified/sedimentary rock masses in Quangninh coal mine area,Vietnam, is gradually increasing. Rock mass in Quangninh is characterized by beddings between rock layers. The behavior of stratified rock masses surrounding the tunnels depends on both the intact rock and the beddings between rock layers. The main characteristics of stratified rock masses that need to be considered are their heterogeneity and anisotropy. Depending on the dip angle of rock layers, movements and failure zones developed surrounding the tunnels can be asymmetrical over the vertical axis of tunnel. This asymmetry causes adverse behaviors of the tunnel structures. The objective of this study is to highlight convergences and yielded zones developed in rock masses surrounding noncircular tunnels in Quangninh coal mine area using a finite element method. The presence of bedding joints is explicitly simulated. The numerical results indicated that with the increase in dip angle of bedding joints, the stress asymmetry over the tunnel vertical axis increases. It gradually leads to an asymmetry of the failure zone surrounding the tunnel. An increase of rock mass quality means a decrease of rock mass sensitivity to the discontinuities. In addition,a dip angle of the bedding joints of approximately 45° could be considered as the critical angle at which the rock mass mechanism changes between sliding and bending. | Ngoc Anh Do Daniel Dias Van Diep Dinh Tien Tung Tran Van Canh Dao Viet Doan Dao Phuc Nhan Nguyen | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，1： | 9 |
| 3 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 4 | Significance of inferior wall ischemia in non-dominant right coronary artery anatomy显示文摘AIM To investigate the relationship of inferior wall ischemia on myocardial perfusion imaging in patients with nondominant right coronary artery anatomy.METHODS This was a retrospective observational analysis of consecutive patients who presented to the emergency department with primary complaint of chest pain.Only patients who underwent single photon emission computed tomography(SPECT)myocardial perfusion imaging(MPI)were included.Patients who showed a reversible defect on SPECT MPI and had coronary angiography during the same hospitalization was analyzed.Patients with prior history of coronary artery disease(CAD)including history of percutaneous coronary intervention and coronary artery bypass graft surgerys were excluded.True positive and false positive results were identified on the basis of hemodynamically significant CAD on coronary angiography,in the same territory as identified on SPECT MPI.Coronary artery dominance was determined on coronary angiography.Patients were divided into group 1 and group 2.Group1 included patients with non-dominant right coronary artery(RCA)(left dominant and codominant).Group2 included patients with dominant RCA anatomy.Demographics,baseline characteristics and positive predictive value(PPV)were analyzed for the two groups.RESULTS The mean age of the study cohort was 57.6 years.Sixtyone point seven percent of the patients were males.The prevalence of self-reported diabetes mellitus,hypertension and dyslipidemia was 36%,71.9%and 53.9%respectively.A comparison of baseline characteristics between the two groups showed that patients with a non-dominant RCA were more likely to be men.For inferior wall ischemia on SPECT MPI,patients in study group 2 had a significantly higher PPV,32/42(76.1%),compared to patients in group 1,in which only 3 out of the 29 patients(10.3%)had true positive results(P value<0.001 Z test).The difference remained statistically significant even when only patients with left dominant coronary system(without co-dominant)were compared to patients with right dominant system(32/40,76.1%in right dominant group,3/19,15.8%in left dominant group,P value<0.001 Z test).There was no significant difference in mean hospital stay,re-hospitalization,and in-hospital mortality between the two groups.CONCLUSION The positive predictive value of SPECT MPI for inferior wall ischemia is affected by coronary artery dominance.More studies are needed to explain this phenomenon. | Ali Osama Malik Oliver Abela Subodh Devabhaktuni Arhama Aftab Malik Gayle Allenback Chowdhury H Ahsan Sanjay Malhotra Jimmy Diep | 2017 | World Journal of Cardiology2017，9，3： | 2 |
| 5 | 促进创面愈合的抗菌肽外用制剂的现状与前景显示文摘慢性创面感染和随后产生的抗生素耐药是影响全世界数百万人的严重临床问题。当机体接触病原体后,可通过产生抗菌肽快速有效杀灭病原体。抗菌肽是包含多达100个L-氨基酸残基的线性或圆形寡肽,可形成二级结构。虽然氨基酸序列不尽相同,似得益于碱性残基、类似细胞膜的两亲性结构和疏水性序列的普遍存在,绝大多数抗菌肽可凭借其阳离子特性与微生物细胞膜上的阴离子磷脂发生静电相互作用。 | 孙佳辰(编译) 申传安(审校) Thapa RK Diep DB TФnnesen HH | 2021 | 中华烧伤杂志2021，37，12： | 2 |
| 6 | Optimization of the dispersion of gold and platinum nanoparticles on indium tin oxide for the electrocatalytic oxidation of cysteine and arsenite显示文摘 | Diep Vu Ca Sun Laisheng James A Cox | 2006 | Electrochim Acta2006，51，11： | 1 |
| 7 | Performance evaluation of multiple refererce station GPS RTK for a medium scale network 显示文摘 | Farrell Jay Diep Paul Alves Gerard Lachapelle | 2004 | Journal of Global Positioning System2004，3，1： | 1 |
| 8 | PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin Ⅱ-infused rats显示文摘 | Diep QN Benkirane K Amiri F | | 0，，： | 1 |
| 9 | The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system显示文摘 | Diep DB Axelsson L Grefsli C | 2000 | Microbiology2000，146，： | 1 |
| 10 | A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export 显示文摘 | Havarstein L S Diep D B Nes I F | 1995 | Mol Microbiol1995，16，2： | 1 |
| 11 | The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes显示文摘 | Diep C B Kleivi K Ribeiro F R | 2006 | Genes Chromosomes Cancer2006，45，1： | 1 |
| 12 | Long-term effects of the PPAR gamma activator pioglitazone on cardiac inflammation in stroke-prone spontaneously hypertensive rats 显示文摘 | Diep QN Amiri F Benkirane K | 2004 | Can J Physi olPharmacol2004，82，11： | 1 |
| 13 | increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails显示文摘 | Pan E8 Diep BA Carleton HA | 2003 | Olin Infect Dis2003，37，10： | 1 |
| 14 | Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men显示文摘 | DIEP BA CHAMBERS HF GRABER CJ | 2008 | Ann Intern Med2008，148，4： | 1 |
| 15 | Widespread skin and soft-tissue infections to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin显示文摘 | Diep BA Sensabargh GF Somboona NS | 2004 | J Clin Microbiol2004，42，5： | 1 |
| 16 | Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin Ⅱ-induced hypertension显示文摘 | Diep QN EI Mabrouk M Yre P | 2002 | Am J Physiol Heart Circ Physiol2002，282，5： | 1 |
| 17 | PPAR-gamma inhibits Ang Ⅱ -induced cell growth via SHIP2 and 4E-BP1 显示文摘 | Benkirane K Amiri F Diep QN | 2006 | Am J Physiol Heart Circ Physiol2006，290，1： | 1 |
| 18 | Antagonistic activity of Lactobacillus plantarum Cll :two new two-peptide bacteriocins,plantaricins E F and J K,and the induction factor plantaricin A显示文摘 | Anderssen E L Diep D B Nes I F | 1998 | Appl Environ Microbiol1998，64，： | 1 |
| 19 | Increased expression of peroxisome proliferator-activated receptor-alpha and -gamma in blood vessels of spontaneously hypertensive rats 显示文摘 | Diep QN Schiffrin EL | 2001 | Hypertension2001，38，2： | 1 |
| 20 | PPARa activator effects on Ang II-induced vascular oxidative stress and inflammation显示文摘 | Diep QN Amiri F Touyz RM Cohn JS Endemann D Neves MF | 2002 | Hypertension2002，40，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员