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| 1 | 疑似或已确诊为冠状动脉疾病的患者其静息心率的长期预后预测价值 | Diaz A. Bourassa M. G. Guertin M.- C. Tardif J. - C. 滕增辉 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，10： | 43 |
| 2 | Overlapping expression of microRNAs in human embryonic colon and colorectal cancer显示文摘MicroRNAs (miRNAs ) 为调整房间区别并且维持干细胞的 pluripotent 状态是必要的。尽管特定的 miRNAs 的 dysregulation 与癌症的某些类型被联系了,到日期,没有证据连接了 miRNA 表示在胚胎并且肿瘤纸巾。我们在人的胚胎的结肠组织,并且在 colorectal 癌症估计了成熟 miRNAs 的表示并且配对正常结肠组织。重叠 miRNA 表示在胚胎的结肠的 mucosa 和 colorectal 癌症之间被检测。我们发现了 miR-17-92 聚类,调整在两个盒子中的房间增长并且它的目标, E2F1,在人的冒号开发和结肠的 carcinogenesis 展出表示的一个类似的模式。在 situ,杂交在地窟祖先分隔空间证实了 miR-17-5p 的表示的高水平。我们断定 miRNA 小径在胚胎的开发和结肠的上皮的肿瘤的转变起一个主要作用。 | Mariano Monzo Alfons Navarro Eva Bandres Rosa Artells Isabel Moreno Bemat Gel Rafael Ibeas Jose Moreno Francisco Martinez Tania Diaz Antonio Martinez Olga Balague Jesus Garcia-Foncillas | 2008 | Cell Research2008，18，8： | 32 |
| 3 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 4 | 放电等离子超快速烧结SiC-Al_2O_3纳米复相陶瓷显示文摘本文介绍用非均相沉淀法制备的纳米SiC-Al2O3复合粉体经放电等离子超快速烧结得到晶内型的纳米复相陶瓷,超快速烧结的升温速率为600℃/min,在烧结温度不保温,迅即在3min内冷却至600℃以下.与热压烧结相比,可降低烧结温度200℃以上.力学性能研究结果表明,在1450℃超快速烧结得到的纳米复相陶瓷的抗弯强度高达1000MPa,维氏硬度为19GPa,断裂韧性也比Al2O3有所提高.TEM像显示纳米SiC颗粒大多分布在Al2O3母体晶粒内,而断裂表面的SEM像表明,穿晶断裂是其主要的断裂模式,这是所制备的纳米复相陶瓷力学性能大幅提高的主要原因. | 高濂 王宏志 洪金生 宫本大树 DIAZ DE LA TORRE SEBASTIAN | 1999 | 无机材料学报1999，14，1： | 22 |
| 5 | Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction显示文摘The product of the A_b^0(B^0) differential production cross-section and the branching fraction of the decay A_b^0→J/ψpK^-(B^0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,and rapidity,y.The kinematic region of the measurements is p_T <20 GeV/c and 2.0 | O.Kochebina M.Kolpin I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles R.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C.J.G.Onderwater B.Osorio Rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.Patel M.Patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci A.Pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard C.Prouve V.Pugatch A.Puig Navarro G.Punzi W.Qian R.Quagliani B.Rachwal J.H.Rademacker M.Rama M.S.Rangel I.Raniuk N.Rauschmayr G.Raven F.Redi S.Reichert M.M.Reid A.C.dos Reis S.Ricciardi S.Richards M.Rihl K.Rinnert V.Rives Molina P.Robbe A.B.Rodrigues E.Rodrigues J.A.Rodriguez Lopez P.Rodriguez Perez S.Roiser V.Romanovsky A.Romero Vidalt J.W.R onayne M.Rotondo J.Rouvinet T.Ruf P.Ruiz Valls J.J.Saborido Silva N.Sagidova P.Sail B.Saitta V.Salustino Guimaraes C.Sanchez Mayordomo B.Sanmartin Sedes R.Santacesaria C.Santamarina Rios M.Santimaria E.Santovetti A.Sarti C.Satriano A.Satta D.M.Saunders D.Savrina M.Schiller H.Schindler M.Schlupp M.Schmelling T.Schmelzer B.Schmidt O.Schneider A.Schopper M.Schubiger M.-H.Schune R.Schwemmer B.Sciascia A.Sciubba A.Semennikov N.Serra J.Serrano L.Sestini P.Seyfert M.Shapkin I.Shapoval Y.Shcheglov T.Shears L.Shekhtman V.Shevchenko A.Shires B.G.Siddi R.Silva Coutinho L.Silva de Oliveira G.Simi M.Sirendi N.Skidmore T.Skwarnicki E.Smith E.Smith I.T.Smith J.Smith M.Smith H.Snoek M.D.Sokoloff F.J.P.Soler F.Soomro D.Souza B.Souza De Paula B.Spaan P.Spradlin S.Sridharan F.Stagni M.Stahl S.Stahl S.Stefkova O.Steinkamp O.Stenyakin S.Stevenson S.Stoica S.Stone B.Storaci S.Stracka M.Straticiuc U.Straumann L.Sun W.Sutcliffe K.Swientek S.Swientek V.Syropoulos M.Szczekowski P.Szczypka T.Szumlak S.T'Jampens A.Tayduganov T.Tekampe M.T eklishyn G.Teilarini F.Teubert C.Thomas E.Thomas J.van Tilburg V.Tisserand M.Tobin J.Todd S.Tolk L.Tomassetti D.Tonelli S.Topp-Joergensen N.Torr E.Tournefier S.Tourneur K.Trabelsi M.T.Tran M.Tresch A.Trisovic A.Tsaregorodtsev P.Tsopelas N.Tuning A.Ukleja A.Ustyuzhanin U.Uwer C.Vacca V.Vagnonit G.Valentit A.Vallier R.Vazquez Gomez P.Vazquez Regueiro C.Vazquez Sierra S.Vecchi J.J.Velthuis M.Veltri G.Veneziano M.Vesterinen B.Viaud D.Vieira M.Vieites Diaz X.Vitasis-Cardona V.Volkov A.Vollhardt D.Volyanskyy D.Voong A.Vorobyev V.Vorobyev C.Voβ J.A.de Vries R.Waldi C.Wallace R.Wallace J.Walsh S.Wandernoth J.Wang D.R.Ward N.K.Watson D.Websdale A.Weiden M.Whitehead G.Wilkinson M.Wilkinson M.Williams M.P.Williams T.Williams F.F.Wilson J.Wimberley J.Wishahi W.Wislicki M.Witek G.Wormser S.A.Wotton S.Wright K.Wyllie Y.Xie Z.Xu Z.Yang J.Yu X.Yuan O.Yushchenko M.Zangoli M.Zavertyaev L.Zhang Y.Zhang A.Zhelezov A.Zhokhov L.Zhong S.Zucchelli | 2016 | Chinese Physics C2016，40，1： | 23 |
| 6 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 7 | Molecular aspects of intestinal calcium absorption显示文摘Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3steps: the entrance of Ca2+ across the brush border membranes(BBM) of enterocytes through epithelial Ca2+ channels TRPV6, TRPV5, and Cav1.3; Ca2+ movement from the BBM to the basolateral membranes by binding proteins with high Ca2+ affinity(such as CB9k); and Ca2+ extrusion into the blood. Plasma membrane Ca2+ ATPase(PMCA1b) and sodium calcium exchanger(NCX1) are mainly involved in the exit of Ca2+ from enterocytes. A novel molecule, the 4.1R protein, seems to be a partner of PMCA1 b, since both molecules colocalize and interact. The paracellular pathway consists of Ca2+ transport through transmembrane proteins of tight junction structures, such as claudins 2, 12, and 15. There is evidence of crosstalk between the transcellular and paracellular pathways in intestinal Ca2+ transport. When intestinal oxidative stress is triggered, there is a decrease in the expression of several molecules of both pathways that inhibit intestinal Ca2+ absorption. Normalization of redox status in the intestine with drugs such as quercetin, ursodeoxycholic acid, or melatonin return intestinal Ca2+ transport to control values. Calcitriol [1,25(OH)2D3] is the major controlling hormone of intestinal Ca2+ transport. It increases the gene and protein expression of most of the molecules involved in both pathways. PTH, thyroid hormones, estrogens, p ro l a c t i n, g ro w t h h o r m o n e, a n d g l u c o c o r t i c o i d s apparently also regulate Ca2+ transport by direct action, indirect mechanism mediated by the increase of renal 1,25(OH)2D3 production, or both. Different physiological conditions, such as growth, pregnancy, lactation, and aging, adjust intestinal Ca2+ absorption according to Ca2+ demands. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism. | Gabriela Diaz de Barboza Solange Guizzardi Nori Tolosa de Talamoni | 2015 | World Journal of Gastroenterology2015，21，23： | 20 |
| 8 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 9 | 介绍一种新的具有重要临床意义的浸润性子宫颈管腺癌分类系统显示文摘最近,新子宫颈管腺癌分类系统被提出。该系统将肿瘤分为三型。A型:肿瘤常由界限清楚的呈巢、簇状腺体排列的小叶状结构;B型:肿瘤表现为局部破坏性浸润,显示促纤维增生间质围绕不规则或边界不清或不完整的腺体,间质中散在单个或小簇状肿瘤细胞;C型:肿瘤表现为弥漫浸润性生长,伴广泛的促纤维间质反应。 | Roma A A Diaz De Vivar A Park K J 康锶鹏 余英豪 | 2015 | 临床与实验病理学杂志2015，31，11： | 17 |
| 10 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 11 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice显示文摘Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles(NFTs); these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone(TIB) have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB(0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated Tau(PHF-1) proteins and the regulation of GSK3β/Akt/PI3 K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3 K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB: it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3 K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes. | Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian Guerra-Araiza | 2017 | Neural Regeneration Research2017，12，4： | 12 |
| 12 | Increased postoperative complications after protective ileostomy closure delay: An institutional study显示文摘AIM: To study the morbidity and complications as-sociated to ileostomy reversal in colorectal surgery pa-tients, and if these are related to the time of closure. METHODS: A retrospective analysis of 93 patients, who had undergone elective ileostomy closure between 2009 and 2013 was performed. Demographic, clinical and surgical variables were reviewed for analysis. All complications were recorded, and classified according to the Clavien-Dindo Classification. Statistical univariate and multivariate analysis was performed, setting a P value of 0.05 for significance.RESULTS: The patients had a mean age of 60.3 years, 58% male. The main procedure for ileostomy cre-ation was rectal cancer(56%), and 37% had received preoperative chemo-radiotherapy. The average delay from creation to closure of the ileostomy was 10.3 mo. Postoperative complications occurred in 40% of the pa-tients, with 1% mortality. The most frequent were ileus(13%) and wound infection(13%). Pseudomembra-nous colitis appeared in 4%. Increased postoperative complications were associated with delay in ileostomyclosure(P = 0.041). Male patients had more complica-tions(P = 0.042), mainly wound infections(P = 0.007). Pseudomembranous colitis was also associated with the delay in ileostomy closure(P = 0.003). End-to-end in-testinal anastomosis without resection was significantly associated with postoperative ileus(P = 0.037). CONCLUSION: Although closure of a protective il-eostomy is a fairly common surgical procedure, it has a high rate of complications, and this must be taken into account when the indication is made. The delay in stoma closure can increase the rate of complications in general, and specifically wound infections and colitis. | Ines Rubio-Perez Miguel Leon Daniel Pastor Joaquin Diaz Dominguez Ramon Cantero | 2014 | World Journal of Gastrointestinal Surgery2014，6，9： | 11 |
| 13 | 非洲裔美国人体力活动与高血压发生的相关性显示文摘非洲裔美国人在美国各种族(民族)中高血压患病率(男性为40.8%,女性为41.5%)最高。有证据表明,与美国其他种族(民族)相比,非洲裔美国人高血压与因心肌梗死、脑卒中和终末期肾脏疾病引起的过早功能丧失和死亡呈不成比例地升高相关。需要确定控制非洲裔美国人危险因素的措施,以减轻其发生高血压的风险。在许多其他人群中已证实,体力活动对预防高血压有保护作用。因此,高血压指南推荐采用体力活动作为预防性生活行为方式。 | Diaz KM Booth JN 3rd Seals SR Abdalla M Dubbert PM Sims M Ladapo JA Redmond N Muntner P Shimbo D | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 14 | Diagnosis and treatment of pancreas divisum: A literature review显示文摘Background:Pancreas divisum is a congenital embryological disease caused by a lack of fusion between the ventral and dorsal pancreatic ducts in the early stages of embryogenesis.Recurrent acute pancreatitis,chronic pancreatitis or chronic abdominal pain are the main clinical syndromes at presentation and occur in only 5%of the patients with pancreas divisum.This review aimed to discuss diagnosis and treatment strategies in patients with symptomatic pancreas divisum.Data sources:We report a literature review from 1990 up to January 2018 to explore the various diagnostic modalities and surgical techniques and results reported in the surgical treatment of pancreas divisum.Results:There are limited reports available on this topic in the literature.We analyzed and described the main indications in the treatment of pancreas divisum,focusing on surgical treatment and a discussion of the different approaches.Furthermore,we report the results from our experience in two cases of pancreas divisum treated by pancreatic head resection with segmental duodenectomy(the Nakao procedure).Conclusions:Pancreas divisum is a common pancreatic malformation in which only a few patients develop a symptomatic disease.Surgical treatment is needed in case of endoscopic drainage failure and in cases complicated with chronic pancreatitis and local complications.Many techniques,of greater or lesser complexity,have been proposed. | Valentina Ferri Emilio Vicente Yolanda Quijano Benedetto Ielpo Hipolito Duran Eduardo Diaz Isabel Fabra Riccardo Caruso | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 9 |
| 15 | 日粮中添加桑叶粉对扬州鹅饲料利用率及生长和屠宰性能的影响显示文摘在扬州鹅的基础饲料中分别添加0%、2%、4%、6%和8%5种不同质量分数的桑叶粉,分析添食桑叶粉对扬州鹅饲料利用率以及鹅生长性能、生理生化指标和屠宰性能的影响。结果显示,随着桑叶粉添加量的增加,饲料中的干物质、粗灰分、粗蛋白、粗纤维、粗脂肪、钙、磷以及能量利用率均呈现下降趋势;与对照组相比,饲粮中添加6%和8%桑叶粉可显著降低扬州鹅的平均日增体质量(P<005),提高仔鹅的料重比;添加2%桑叶粉可在一定程度上增加胸肌厚度,但添加量达到4%时又有所下降;饲料中添加桑叶粉能降低扬州鹅血液中的总胆固醇和甘油三酯含量以及碱性磷酸酶活性;随着桑叶粉添加量的增加,仔鹅半净膛率有所下降,肝脏质量减小,腹脂率下降。综合上述试验结果,确定扬州鹅日粮中的最佳桑叶粉添加量为4%。 | 赵卫国 孙梦琦 侯启瑞 杨海明 黄先智 方荣俊 Eng Andres Diaz Veiga 李龙 | 2019 | 蚕业科学2019，45，3： | 8 |
| 16 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 17 | 猪霉菌毒素中毒的新概念显示文摘霉菌毒素是真菌的次级代谢产物,可以降低畜禽生产性能和改变新陈代谢(wannemacher等,1991)。动物采食被霉菌毒素污染的饲料而引发的病理状态称为霉菌毒素中毒。猪霉菌毒素中毒会对养猪生产造成严重的不良影响。本文综述了各种霉菌毒素对猪生长性能、繁殖性能和免疫功能的影响,各种霉菌毒素间的协同作用以及猪霉菌毒素中毒的最新研究成果。 | Trevor K Smith Gabriel Diaz Swamy H V LN 苗朝华(摘译) | 2007 | 养猪2007，，5： | 6 |
| 18 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 19 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 20 | Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture显示文摘Pyridine 核苷酸, ascorbate 和谷胱甘肽是在植物房间的主要氧化还原作用代谢物,与在细胞的氧化还原作用动态平衡和房间周期的规定的特定的角色。然而,代谢物在指数的生长期间分享的这些的规定和他们在细胞周期的精确功能尚待被描绘。在在文化的 Arabidopsis 房间的指数的生长期间的许多 ascorbate,谷胱甘肽,和 pyridine 核苷酸的现在的分析为每这些氧化还原作用水池的微分规定提供证据。Ascorbate 早很充满生长周期,但是谷胱甘肽在这个点是低的。到 dehydroascorbate 的细胞的 ascorbate 和到谷胱甘肽二硫化物比率的减少的谷胱甘肽(GSH ) 高、不变,但是 pyridine 核苷酸分享大部分在指数的生长的时期上被氧化并且一旦生长停止了,仅仅变得更多减少。谷胱甘肽水池增加了与同时 poly (自动数据处理核糖) 聚合酶(PARP ) 活动并且一次由 transcriptome 信息是的高房间周期活动随许多 PARP1 和 PARP2 mRNAs 的增加显示了。在在细胞质和原子核之间的 GSH 的细胞内部的划分的显著变化被观察。由冲淡的指数的生长阶段的扩展或改变导致的媒介在谷胱甘肽和菸碱腺嘌 dinucleotide 增加,氧化形式( NAD ) -plus-nicotinamide 腺嘌 dinucleotide ,减少的形式( NADH )水池并且到更高的 NAD/NADH 比率但是菸碱腺嘌 dinucleotide 磷酸盐,氧化形式( NADP ) -plus-nicotinamide 腺嘌 dinucleotide 磷酸盐,减少的形式( NADPH )水池尺寸,和 NAPD/NADPH 比率是影响的少得多。在指数的生长阶段结束了以前, ascorbate,谷胱甘肽,和 pyridine 核苷酸水池和 PARP 活动减少了。我们断定在生长周期期间处于细胞内部的氧化还原作用状态有显著变化,但是氧化还原作用动态平衡被主要氧化还原作用 pyridine 核苷酸,谷胱甘肽,和 ascorbate 水池的相互影响维持。在 PARP 表示和活动和 GSH 累积并且发现那 GSH 能被招募到原子核之间的关联建议在氧化还原作用规定和原子酶活动之间的一种关系。 | Till K. Pellny Vittoria Locato Pedro Diaz Vivancos Jelena Markovic Laura De Gara Federico V. Pallardo Christine H. Foyer | 2009 | Molecular Plant2009，2，3： | 4 |
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