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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Optical coding of mammalian cells using semiconductor quantum dots 显示文摘 | Mattheakis L C Dias J M Choi Y J | 2004 | Anal Biochem2004，322，2： | 1 |
| 4 | Robust H∞ filtering for uncertain discrete-time state-delayed 显示文摘 | Palhares R M SouzaQu C E Dias Peres P L | 2001 | IEEE Trans on Sig Processing2001，49，8： | 1 |
| 5 | Dealing with imprecise information in group multicriteria decisions: a methodology and a GDSS architechture显示文摘 | Dias L C Cl'maco J N | 2005 | European Journal of Operational Research2005，160，2： | 1 |
| 6 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 7 | Super-efficiency and stability intervals in additive DEA显示文摘 | GouveiaMC Dias L C Antunes C H | 2013 | J of the Operational Research Society2013，64，1： | 1 |
| 8 | Optimization of the Polymerase Chain Reaction with Regard to Fidelity:Modified T7,Taq and Vent DNA Polymerase显示文摘 | Ling L L Keohavong P Dias C | 1991 | PCR Methods Appl1991，，1： | 1 |
| 9 | Immobilization of Fe, Mn and Co tetraphenylporphyrin complexes in MCM-41 and their catalytic activity in cyclohexene oxidation reaction by hydrogen peroxide 显示文摘 | COSTA A A GHESTI G F MACEDO J L BRAGA V S SANTOS M M DIAS J A DIAS S C L | 2008 | J Mol Catal A: Chem2008，282，： | 1 |
| 10 | Measurement of Host-to-Activator Transfer Efficiency in Nano-Crystalline Y2 03:Eu3 + under VUV Excitation显示文摘 | Waite C Mann R Dias A L | 2013 | Journal of Solid State Chemistry2013，198，： | 1 |
| 11 | Soy protein concentrate as a protein source for Senegalese sole( Solea senegalensis Kaup 1858 ) diets : Effects on growth and amino acid metabolism of postlarvae 显示文摘 | Aragao C Conceicao L E C Dias J | 2003 | Aquaculture Research2003，34，15： | 1 |
| 12 | Life- threatening thromboeytopenia and nephrotic syndrome due to focal segmental glomerulosclerosis associated with pegy- lated interferon alpha-2b and ribavirin treatment for hepatitis 显示文摘 | Alves Couto C Costa Faria L Dias Ribeiro D | 2006 | Liver Int2006，26，10： | 1 |
| 13 | An electronic tongue taste evaluation: Identification Of goat milk adulteration with bovine milk显示文摘 | L A Dias A M Peres A C A Veloso | 2009 | Sensors and Actuators B2009，136，： | 1 |
| 14 | Yellow passion-fruit shell as biosorbent to remove Cr(Ill) and Pb(11) from aqueous solution显示文摘 | Jacques R A Lima E C Dias S L P | 2007 | Separation and Purification2007，57，1： | 1 |
| 15 | An efficient procedure for the synthesis of 2 - N - boc - amino - 3,5 - diols 显示文摘 | DIAS L C FATFORI J PEREZ C C | 2008 | Tetrahedron2008，64，： | 1 |
| 16 | Effect of dietary non-protein energy levels on condition and oxidative status of Senegalese sole (Solea senegalensis) juveniles显示文摘 | RUEDA-JASSO R CONCEICAO L E C DIAS J | 2004 | Aquaculture2004，231，15： | 1 |
| 17 | An electronic tongue taste evaluation:Identification of goat milk adulteration with bovine milk显示文摘 | L A Dias A M Peres A C A Veloso | | Sensors and Actuators B0，136，： | 1 |
| 18 | ELECTRE TRI for Groups with Imprecise Information on Parameter Values显示文摘 | Dias L C Joaon C | 2000 | Group Decision and Negotiation2000，9，： | 1 |
| 19 | Biologically active steroid and thyroid hormones stimulate secretion of SHBG by human term pla- centa in culture 显示文摘 | Dia L Queipo G Carino C | 1997 | Arch Med Res1997，28，1： | 1 |
| 20 | An Aggregation/Disaggregation Approach to Obtain Robust Conclusions with ELECTRE TRI显示文摘 | Dias L C Mousseau V Figueira J | 2002 | European Journal of Operation Research2002，138，： | 1 |
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