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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Structural phase relations in perovskite-structured BiFeO_(3)-based multiferroic compounds显示文摘In this review,the state of the art in understanding the structural phase relations in perovskite-structured BiFeO_(3)-based polycrystalline solid solutions is presented and discussed.Issues about the close relation between the structural phase and overall physical properties of the reviewed systems are pointed out and discussed.It is shown that,by adjusting the structural symmetric arrangement,the ferroelectric and magnetic properties of BiFeO_(3)-based polycrystalline solid solutions can be tuned to find specific multifunctional applications.However,an intrinsic mechanism linking structural arrangement and physical properties cannot be identified,revealing that this subject still deserves further discussion and investigation. | Valdirlei Fernandes FREITAS Gustavo Sanguino DIAS Otávio Algusto PROTZEK Diogo Zampieri MONTANHER Igor Barbosa CATELLANI Daniel Matos SILVA Luiz Fernando CÓTICA Ivair Aparecido dos SANTOS | 2013 | Journal of Advanced Ceramics2013，2，2： | 2 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hpvcxwpvwpfuc6f6q.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 5 | Cutting edge:dendritic cells are essential for in vim IL-12 production and development of resistance against Toxoplasma gondii infection in mice显示文摘 | Liu C H Fan Y T Dias A | 2006 | J Immunol2006，177，： | 1 |
| 6 | Effect of medium renovation and incubation temperature regimes on tronchuda cabbage microspore culture embryogenesis显示文摘 | Dias J S Correia M C | 2002 | Sci Hortic2002，93，： | 1 |
| 7 | Optical coding of mammalian cells using semiconductor quantum dots 显示文摘 | Mattheakis L C Dias J M Choi Y J | 2004 | Anal Biochem2004，322，2： | 1 |
| 8 | Inorganic ceramic/polymer ferroe lectric composite electrets 显示文摘 | DIAS C J DAS-Gupta D K | 1996 | IEEE Trans Dielectr Electr Insul1996，3，5： | 1 |
| 9 | Rapid silver staining and recover of PCR products separated in polyacrylamide gels显示文摘 | SANGUINETTI C J DIAS N E SIMPSON A J G | 1994 | Bio techniques1994，17，： | 1 |
| 10 | Robust H∞ filtering for uncertain discrete-time state-delayed 显示文摘 | Palhares R M SouzaQu C E Dias Peres P L | 2001 | IEEE Trans on Sig Processing2001，49，8： | 1 |
| 11 | Risk of human exposure to paralytic loxlns of algal origin显示文摘 | Batoreu M C C Dias E Pereira P | 2005 | Environmental Toxicology and Pharmacology2005，19，： | 1 |
| 12 | Measurement of the angular acceleration using a PVDF and a piezo-composite显示文摘 | Marat-Mendes Dias C J Marat-Mendes J N | | 0，，： | 1 |
| 13 | Cadmium toxicity affects photosynthesis and plant growth at different levels 显示文摘 | Dias blC Monteiro C Moutinho - Pereira J | 2013 | Aeta Physiologiae Plantarum2013，35，4： | 1 |
| 14 | Novel antiviral thera- peutics to control foot - and - mouth disease 显示文摘 | DIAS C C MORAES M P WEISS M | 2012 | J Interferon Cyto- kine Res2012，32，10： | 1 |
| 15 | Effect of heat-moisture treatment on rice starch of varying amylose content显示文摘 | Elessandra da Rosa Zavareze Cátia Regina Storck Luis Antonio Suita de Castro Manoel Artigas Schirmer Alvaro Renato Guerra Dias | 2009 | Food Chemistry2009，，2： | 1 |
| 16 | 术中脑组织氧分压偏低与动脉瘤性蛛网膜下腔出血术后血管痉挛相关(英文)显示文摘Background Vasospasm is a frequent complication of subarachnoid hemorrhage ( SAH) ,implicated in poor outcome,and prediction of its occurrence might be important on the therapeutic approach of this condition. Brain oxygenation in aneurysmal SAH was prospectively monitored during surgery in 28 patients,using brain tissue oxygen pressure ( PbtO 2 ) ,studying its association with the occurrence of post-operative vasospasm,detected by transcranial Doppler. Methods PbtO 2 monitoring was performed during surgery of 28 patients with aneurysmal SAH,using a polarographic microcatheter ( Licox; GMS,Kiel,Germany) ,inserted into the cerebral tissue. The aneurysms were localized in the anterior communicating artery ( AcoA) complex ( eight cases) ,in the posterior communicating artery ( Pcom) origin ( seven cases) ,and in the middle cerebral artery ( MCA) bifurcation ( 13 cases) . Basal PbtO 2 values,obtained immediately before application of temporary or definitive clips,were studied according to age,clinical status and CT findings. The association between the basal values and the occurrence of increased blood flow velocity in the post-operative transcranial Doppler ( TCD vasospasm) was investigated. Results Post-operative TCD vasospasm developed in 13 patients,all of them with basal values inferior to 10 mmHg. PbtO 2 basal value was significantly lower in cases that developed TCD vasospasm. This association was independent of age, clinical status,or CT findings. Conclusion The finding of low intraoperative basal PbtO 2 values may be an indicator for a high risk of occurrence of post-operative TCD vasospasm in cases of aneurysmatic SAH. | Cerejo A Silva PA Vilarinho A Dias C Vaz R | 2012 | 中华神经外科疾病研究杂志2012，11，5： | 1 |
| 17 | 显示文摘 | Portela M F | 1995 | J Catal1995，157，： | 1 |
| 18 | ATR-FTIR: studies of poly ( propylene oxide)/polybutadiene hi-soft segment urethane/urea membranes 显示文摘 | Queiroz D P De Pinho M N Dias C | 2003 | Macromolecules2003，36，11： | 1 |
| 19 | Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study 显示文摘 | Dias A Garcia C Majewski M | 2011 | Dig Dis Sci2011，56，11： | 1 |
| 20 | Social deprivation and hand injury显示文摘 | Horton T C Dias JJ Burke FD | 2007 | J Hand Surg2007，329，3： | 1 |
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