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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Parallel computing applied to the stochastic dynamic programming for long term operation planning of hydrothermal power systems显示文摘 | Dias B H Tomim M A Marcato A L M | 2013 | European Journal of Operational Research2013，229，： | 1 |
| 3 | Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study 显示文摘 | Dias A Garcia C Majewski M | 2011 | Dig Dis Sci2011，56，11： | 1 |
| 4 | Improving elms performance under drought stress: The pretreatment with abscisic acid显示文摘 | Dias M C Oliveira H Costa A | 2014 | Environmental and Experimental Botany2014，100，： | 1 |
| 5 | The effect of stirring and seeding on the AcPheLeuNH2 synthesis and crystallization in a reversed micellar system显示文摘 | FELICIANO A S DIAS A I PRAZERES D M F | 2000 | Enzy & Microb Tech2000，27，： | 1 |
| 6 | The role of body weight,waist-to-hip ratio,and breast size in judgments of female attractiveness显示文摘 | Furnham A Dias M Mcclelland A | 1998 | Sex Roles1998，39，3： | 1 |
| 7 | Enzymatic kinetic of cel- lulose hydrolysis-Inhibition by ethanol and cellobiose 显示文摘 | BEZERRA R M F DIAS A A | 2005 | Applied Biochemistry and Biotechnology2005，126，1： | 1 |
| 8 | Contact endoscopy during microlaryngeal surgery: a new technique for endoscopic examination of the lar-ynx显示文摘 | Andrea M Dias O Santos A | 1995 | Ann Otol Rhinol Laryngol1995，104，5： | 1 |
| 9 | Results of stereotactic radiosurgery of arteriovenous malformations: an analysis of 52 cases显示文摘 | Kemeny A A Dias P S Forster D M | 1989 | J Neurol Neurosurg Psychiatry1989，52，5： | 1 |
| 10 | Regulation of hepatic lipogenesis by dietary protein/energy in juvenile European seabass (Dicentrarchus labrax ) 显示文摘 | Dias J Alvarez M J Diez A | 1998 | Aquaculture1998，161，14： | 1 |
| 11 | An electronic tongue forhoneyclassification显示文摘 | L A Dias A M Peres M Vilas-Boas | 2008 | MicrochimicaActa2008，163，： | 1 |
| 12 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 13 | Risk factors associated with sero-positivity to Toxoplasma gondii in captive neotropical felids from Brazil显示文摘 | Ramossilva J C Marvulo M F Dias R A | 2007 | Prey Vet Med2007，78，34： | 1 |
| 14 | Magnesium and its alloys as orthopedic biomaterials: A review显示文摘 | STAIGER M P PIETAK A M HUADMAI J DIAS G | 2006 | Biomaterials2006，27，9： | 1 |
| 15 | Nanosized and re- usable SiO2/ZrO2 catalyst for highly efficient biodiesel production by soybean ktransesterification显示文摘 | Faria E A Marques J S Dias I M | 2009 | Braz Chem Soc2009，20，： | 1 |
| 16 | Rare earth elements complexation with humic acid显示文摘 | POURRET O DAVRANCHE M GRUAU G DIA A | 2007 | Chem Geol2007，243，12： | 1 |
| 17 | Immobilization of Fe, Mn and Co tetraphenylporphyrin complexes in MCM-41 and their catalytic activity in cyclohexene oxidation reaction by hydrogen peroxide 显示文摘 | COSTA A A GHESTI G F MACEDO J L BRAGA V S SANTOS M M DIAS J A DIAS S C L | 2008 | J Mol Catal A: Chem2008，282，： | 1 |
| 18 | Autothermal reforming of methane over Ni/r-Al2O3 catalysts: the enhancement effect of small quantities of noble metals显示文摘 | Dias J A C Assaf J M | 2004 | Journal of Power Sources2004，130，12： | 1 |
| 19 | Modified versions of sulfated zirconia as catalysts for the conversion of xylose to furfural显示文摘 | DIAS A S LIMA S PILLINGER M | 2007 | Catalysis Letters2007，114，34： | 1 |
| 20 | Tuning hole mobility in InP nanowires显示文摘 | REBELLO M DIAS S PICININ A | 2012 | Appl Phys Lett2012，101，18： | 1 |
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