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| 1 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 2 | Developmental cognitive neuroscience: progress and potential显示文摘 | MUNAKATA Y CASEY B J DIAMOND A | 2004 | Trends in Cognitive Science2004，8，3： | 1 |
| 3 | Tracheal antimicrobiai peptide,a cysteine-rich peptide from mammalian tracheal mucosa:peptide isolation and cloning of a cDNA显示文摘 | Diamond J Zasloff M Eck H | 1991 | Proc Natl Acad Sci USA1991，88，9： | 1 |
| 4 | Competitive interactions between endogenous LTD and LTP in the hippoeampus underlie the storage of emo- tional memories and stress-induced amnesia 显示文摘 | Diamond D M Park C R Campbell A M Woodson J C | 2005 | Hip- pocampus2005，15，： | 1 |
| 5 | Intracerebral hemorrhage: a life-threat ening complication of hypertension during pregnancy显示文摘 | Dai X Diamond J A | 2007 | J Clin Uypertens(Greenwich)2007，9，11： | 1 |
| 6 | Dependence of intestinal amino acid up take on dietary protein or amino acid levels 显示文摘 | Karasov W H Solberg D H Diamond J M | 1987 | Am J Physiol1987，252，： | 1 |
| 7 | Brief overview of maternal triglycerides as a risk factor for preeclampsia显示文摘 | RAY J G DIAMOND P SINGH G | 2006 | BJOG2006，113，4： | 1 |
| 8 | Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome显示文摘 | Diamond JR Ding G Frye J | 1992 | Am J Pathol1992，141，4： | 1 |
| 9 | Contingent Valuation: Is Some Number Better than No Number? 显示文摘 | DIAMOND P A HAUSMAN J A | 1994 | The Journal of Economic Perspectives1994，8，4： | 1 |
| 10 | Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells显示文摘 | Kaiser V Rhodes J | 2000 | Infect Immun2000，68，1： | 1 |
| 11 | Varicocele surgery:a decade’s experience at a children’s hospital显示文摘 | Diamond DA Xuewu J Cilento BG Jr | 2009 | BJU Int2009，104，： | 1 |
| 12 | Varistor control of inductive transients显示文摘 | Diamond J M | 1992 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications1992，39，6： | 1 |
| 13 | Phospholipase C gamma- 1 is required downstream of vascular endothelial growth factor during arterial development显示文摘 | LAWSON N D MUGFORD J W DIAMOND B A | 2003 | Genes Dev2003，17，： | 1 |
| 14 | Correlation of protein partitioning in aqueous polymer two-phase systems 显示文摘 | DIAMOND A D HSU J T | 1990 | J Chromatogr A1990，513，： | 1 |
| 15 | Regulation of brush-border enzyme activities and enterocyte migration rates in mouse small intestine 显示文摘 | Ferraris R P Villenas S A Diamond J | 1992 | American Journal of Physiology1992，262，6： | 1 |
| 16 | Elemental Analysis of Individual Fluid Inclusions in Minerals by Secondary Ion Mass Spectrometry (SIMS):Application to Cation Ratios of Fluid In clusions in an Archaean Mesothermal Gold-quartz Vein显示文摘 | DIAMOND L W MARSHALL D D JACKMAN J A | | 0，，03： | 1 |
| 17 | Voluntary activity, cardiovascular and muscular responses to anemia in rats显示文摘 | EDGERTON V R DIAMOND L B OLSON J | 1977 | J Nutr1977，107，9： | 1 |
| 18 | Dammed experiments 显示文摘 | Diamond J M | 2001 | Science2001，，294： | 1 |
| 19 | Increased expression of decorin experimental hydronephrosis显示文摘 | Diamond J R Levinson M Kresberg R | 1997 | Kidey Int1997，51，4： | 1 |
| 20 | ^29Si MAS NMR spectroscopic investigation of alkali Silica reaction product gels显示文摘 | Cong X D Kirkpatrick R J Diamond S | 1993 | Cement and Concrete Research1993，23，4： | 1 |
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