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| 1 | Nitric oxide activation of a potassium channel (BK_(Ca)) in feline lower esophageal sphincter显示文摘AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (LES) to determine its regulation of resting tone and relaxation.METHODS:Freshly enzymatically-digested and isolated circular smooth muscle cells were prepared from each LES region.To study outward K + currents,the perforated patch clamp technique was employed.To assess LES resting tone and relaxation,muscle strips were mounted in perfused organ baths.RESULTS:(1) Electrophysiological recordings from isolated cells:(a) CM was more depolarized than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P < 0.001),and maximal outward current was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The NO donor sodium nitroprusside (SNP) increased outward currents only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P < 0.001) but not SM (23.2 ± 3.1 to 27.0 ± 3.4 pA/pF,P > 0.05);(c) SNP added in the presence of the BK Ca antagonist iberiotoxin (IbTX) produced no increase in the outward current in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA caused a small insignificant inhibition of outward K + currents in both muscles;and (2) Muscle strip studies:(a) Blockade of the nerves with tetrodotoxin (TTX),or BK Ca with IbTX had no significant effect on resting tone of either muscle;and (b) SNP reduced tone in both muscles,and was unaffected by the presence of TTX or IbTX.CONCLUSION:Exogenous NO activates BK Ca only in CM of the cat.However,as opposed to other species,exogenous NO-induced relaxation is predominantly by a non-BK Ca mechanism,and endogenous NO has minimal effect on resting tone. | Marie-Claude L'Heureux Ahmad Muinuddin Herbert Y Gaisano Nicholas E Diamant | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 2 | Sonochemical synthesis and characterization of Ag2S/PVA and CuS/PVA nanocomposite显示文摘 | Kumar R V Palchik O Koltypin Y Diamant Y Gedanken A | 2002 | Ultrasonics Sonochemistry2002，9，2： | 1 |
| 3 | Sonochemical Synthesis and Characterization of Nanometer-size Transition Metal Oxides from Metal Acetates 显示文摘 | Kumar R V Diamant Y Gedanken A | 2000 | Chemistry of Materials2000，12，8： | 1 |
| 4 | Core-shell nanoporous electrode for dye sensitized solar cells:the effect of the SrTiO3 shell on the electronic properties ofthe TiO2 core显示文摘 | Diamant Y Chen S G Melamed O | 2003 | J Phys Chem B2003，107，： | 1 |
| 5 | TiO2 nanocrystalline pigmentedpolyethylene foils for radiative cooling application synthesis and charaction显示文摘 | Masiai Y Diamant yl Aruna S T ei al | 2001 | Langmuir2001，，17： | 1 |
| 6 | Placental lipidand glycogen content in human and experimental diabetes mellitus显示文摘 | Diamant Y Z Metzger B E Freinkel N | 1982 | Am J Obstet Gynecol1982，144，： | 1 |
| 7 | Core-shell nanoporous electrode for dye sensitized solar cells: the effect of the SrTiO3 shell on the electronic properties of the TiO2 Core 显示文摘 | Diamant Y Chen S G Melamed O | 2003 | Journal of Physical Chemistry B2003，107，9： | 1 |
| 8 | Core-shell nanoporous electrode for dye sensitized solar cells:the Effect of the StTiO3 shell on the electronic properties of the TiO2 core显示文摘 | Diamant Y Chen S G Melamed O | 2003 | J Phys Chem B2003，107，： | 1 |
| 9 | Preparation of Nb2O5 coated TiO2 nanoporous electrodes and their application in dye-sensitized solar cells显示文摘 | Chappel S Diamant Y | 2001 | Chem Mater2001，13，12： | 1 |
| 10 | Sonochemical preparation and characterization of nanocrystalline copperoxide embedded in poly(vinyl alcohol)and its effect on crystal growth of copper oxide显示文摘 | VIJAYAKAR R ELGAIEL R DIAMANT Y | 2007 | Langmiur2007，17，5： | 1 |
| 11 | Sonochemical syn- thesis of amorphous Cu and nanocrystalline Cu20 embedded in a polyaniline matrix显示文摘 | Kumar R Mastai Y Diamant Y | 2001 | J Mater Chem2001，11，4： | 1 |
| 12 | 显示文摘 | Kumar R V Diamant Y Gedanken A | 2000 | Chem Mater2000，12，： | 1 |
| 13 | Sonochemical sythesis and characterization of nanometer size transition metal oxides from metal acetates 显示文摘 | Vijaya R Diamant Y Gedanken A | 2000 | Chem Mater2000，12，8： | 1 |
| 14 | Absorption of Epoxy Resin 显示文摘 | DIAMANT Y G MAROM BROUTMAN L J | 1981 | Journal of Applied Polymer Science1981，26，： | 1 |
| 15 | DSIF Restricts NF-κB signaling by coordinating elongation with m RNA processing of negative feedback genes显示文摘 | Diamant G Amir-Zilberstein L Yamaguchi Y Handa H Dikstein R | 2012 | Cell Rep2012，2，4： | 1 |
| 16 | Transition metal oxides from metal acetates显示文摘 | KUMAR R V DIAMANT Y GEDANKEN A | 2000 | Chem Mater2000，12，： | 1 |
| 17 | Preparation of Nb2 O5 coated TiO2 nanoporous electrodes and their application in dye-sensitized solar cells 显示文摘 | Chen S G Chappel S Diamant Y | 2001 | Chem Mater2001，13，12： | 1 |
| 18 | Sonochemical synthesis of amorphous Cu and nanocrystalline Cu2O embedded in a polyanilme matrix显示文摘 | KUMAR R V MASTAI Y DIAMANT Y GEDANKEN A | | 0，，04： | 1 |
| 19 | Preparation of Nb2O5 coated TiO2 nanoporous electrodes and their application in dye-sensitized solar cells显示文摘 | CHEN S G CHAPPEL S DIAMANT Y | 2001 | Chem Mater2001，13，12： | 1 |
| 20 | Core-shell nanoporous electrode for dye sensitized solar cells: the effect of the SrTiO3 shell on the electronic properties of the TiO2 core 显示文摘 | Diamant Y Chen S G Melamed O | 2003 | Physics Chemistry B2003，107，： | 1 |
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