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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Causes and treatment of idiopathic benign paroxysmal positional vertigo based on endocrinological and other metabolic factors显示文摘The genesis of the Benign Paroxysmal Positional Vertigo(BPPV)seems to be related to some metabolic factors.These factors,such as vitamin D,glucocorticoids,and even thyroid and growth hormones,can affect bone metabolism and the mineralization of otoconia.It also seems to link to factors related to aging or nutritional habits.Besides,since the incidence of BPPV is quantitatively higher in women than in men,female sex steroids could be associated with this process.It could be useful to understand how these factors act in otoconial mineralization if we want to develop treatments aimed at preventing or delaying BPPV recurrences.In this review,we will analyze the role of these metabolic and hormonal factors in otoconial mineralization and in the treatment of BPPV. | Joaquín Guerra Jesús Devesa | 2020 | Journal of Otology2020，15，4： | 3 |
| 3 | Cancer incidence trends in urban Shanghai, 1972-1994: an update 显示文摘 | Jin F Devesa S Chow W | 1999 | Int J Cancer1999，83，： | 1 |
| 4 | Lung cancer 显示文摘 | Travis W D Travis L B Devesa S S | 1995 | Cancer1995，75，1： | 1 |
| 5 | Cancer burden in the year2000:The global picture显示文摘 | Parkin D M Bray F I Devesa S S | 2001 | Eur J Cancer2001，37，8： | 1 |
| 6 | Lymphoma incidence patterns by WHO subtype in the United States,1992-2001显示文摘 | MORTON L M WANG S S DEVESA S S | 2006 | Blood2006，107，： | 1 |
| 7 | Cancer incidence trends in urban Shanghai 1972-1994: An update显示文摘 | Jin F Devesa S S Chow W H | 1999 | Int J Cancer1999，83，4： | 1 |
| 8 | Lung cancer 显示文摘 | Travis W D Travis L B Devesa S S | 1995 | Cancer1995，75，1： | 1 |
| 9 | Epidemiologic trends in esophageal and gastric cancer in the United States显示文摘 | Linda Morris Brown Susan S Devesa | 2002 | Surgical Oncology Clinics of North America2002，，2： | 1 |
| 10 | Antibacterial action of the mucus of turbot 显示文摘 | Fouz B Devesa S Gravningen K | 1990 | Bull Eur Assoc Fish Pathol1990，10，1： | 1 |
| 11 | United States lung carcinoma incidence trends: declining for most histologic types among males, increasing among females显示文摘 | Travis W D Lubin J Ries L Devesa S | 1996 | Cancer1996，77，12： | 1 |
| 12 | Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US显示文摘 | RASTOGI T DEVESA S MANGTANI P | 2008 | Int J Epidemiol2008，37，1： | 1 |
| 13 | Rapid increase in eolorectal cancer rates in urban Shanghai, 1972- 97, in relation to dietary changes 显示文摘 | You WC Jin F Devesa S | 2002 | J Cancer Epidemiol Prey2002，7，： | 1 |
| 14 | Cancer burden in the year 2000: The global picture 显示文摘 | Parkin D M Bray F I Devesa S S | 2001 | Eur J Cancer2001，37，8： | 1 |
| 15 | Descriptive epidemiology of child- hood leukemia显示文摘 | LINET M S DEVESA S S | 1991 | Br J Cancer1991，63，3： | 1 |
| 16 | Epidemiology and risk factors for kidney cancer显示文摘 | Chow W H Dong L M Devesa S S | 2010 | Nat Rev Urol2010，7，5： | 1 |
| 17 | Rapid increase in colorectal cancer rates in urban Shanghai,1972-97,in relation to dietary changes显示文摘 | You W C Jin F Devesa S | | 0，，03： | 1 |
| 18 | Lymphoma incidence patterns by WHO subtype in the United States,1992–2001显示文摘 | Morton L M Wang S S Devesa S S | 2006 | Blood2006，107，1： | 1 |
| 19 | Ulcerative skin and fin lesions in reared turbot,Scophthalmus maximus显示文摘 | Devesa S Barja J L Toranzo A E | 1989 | Journal of Fish Diseases1989，，12： | 1 |
| 20 | Rapid increase in colorectal cancer rates in urben Shanghai, 1972- 97, in relation to dietary changes显示文摘 | You WC Jin F Devesa S | 2002 | Cancer Epidemiol Prey2002，7，3： | 1 |
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