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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Effect of oral vitamin D and calci- um replacement on glycaemic control in South Asian patients with type 2 diabetes 显示文摘 | SabherwaI S Bravis V Devendra D | 2010 | Int J Clin Pract2010，64，8： | 1 |
| 3 | Should doctors perform an elective caesarean section on request? 显示文摘 | Devendra K Arulkumaran S | 2006 | Obstet Gynecol2006，108，： | 1 |
| 4 | Interferon alpha potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity 显示文摘 | Devendra D Eisenbarth G S | 2004 | Clin Immunol2004，111，3： | 1 |
| 5 | Do UGT1A1 and HMOX1 gene promoter polymorphisms increase the risk of hyperhilirubinemia and gallstones in patients with he- reditary spherocytosis 显示文摘 | Warang P Devendra R D'silva S | 2015 | Ann Hematol2015，94，1： | 1 |
| 6 | Should doctors perform an elective caesarean section on request 显示文摘 | Devendra K Arulkumaran S | 2006 | Obstet Gynecol2006，108，： | 1 |
| 7 | A new chlorophycean nickel hyperaccumulator 显示文摘 | Harish S Sundaramoorthy Devendra Kumar | 2008 | Bioresource Technology2008，，99： | 1 |
| 8 | Serum procalcitomin and C-reactive protein levels as markers of bacterial infection:a systematic review and meta-analysis 显示文摘 | Liliana S France G Devendra K | 2004 | Clin Infect Dis2004，39，2： | 1 |
| 9 | Naturally occurring and inducible T-regu-latory cells modulating immune response in allergic asthma显示文摘 | Halvor S Devendra K | 2009 | Am J Respir Crit Care Med2009，180，3： | 1 |
| 10 | Inhibition of cyclooxygenase (COX)-2 expression by tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs显示文摘 | Devendra S Dandekar B Lokeshwar L | 2004 | Clin Cancer Res2004，10，19： | 1 |
| 11 | Medical students’preferences for problem-based learning in relation to culture and personality:a multicultural study显示文摘 | Are Holen Kedar Manandhar Devendra S | 2015 | International Journal of Medical Education2015，，6： | 1 |
| 12 | Air bearing considerations for constant fly height applications 显示文摘 | Devendra S Chhabra Sanford A Bolasna | 1994 | IEEE Transaction of Magnetic1994，30，2： | 1 |
| 13 | Studies in 3,4 diaryl-1,2,5-oxadiazoles and their N oxides: Search for better COX-2 inhibitors显示文摘 | Mange R Y Shrikant T S Devendra S P | 2007 | Acta Pharm2007，57，： | 1 |
| 14 | Proteomics in clinical interventions:Achievements and limitations in biomarker development显示文摘 | Ashima S Chetna S Devendra P | 2007 | Life Sci2007，80，： | 1 |
| 15 | An allele-specific PCR assay for the rapid and serotypespecific detection of Salmonella pullorum显示文摘 | DESAI A R DEVENDRA A CHAE J S | 2005 | Avian Diseases2005，49，4： | 1 |
| 16 | Should doctors perform an elective caesarean section on request?显示文摘 | Devendra K Arulkumaran S | 2003 | Ann Acard MeD Singapore2003，32，5： | 1 |
| 17 | Naturally occurring and Inducible t-regulatoot cells modulating immune response in allergic: asthma显示文摘 | Halvor S Devendra K | 2009 | Am J Respir Crit Care Med2009，180，3： | 1 |
| 18 | Generalizen relationships forestimating soil thermal resistivity显示文摘 | Devendra N S Konchenapalli D | 2000 | Experimental Thermal andFluid Science2000，22，3： | 1 |
| 19 | Generalized procedure for determining thermal resistivity of soils显示文摘 | Arnepalli D N Devendra N S | 2004 | International Journal of Thermal Sciences2004，43，： | 1 |
| 20 | Jaggery: a novel substrate for pullulan production by Aureobasiudium pullulans (FR- T)显示文摘 | S V N Vijayendra Devendra Bansal M S Prasad | 2001 | Processs Biochemistry2001，37，： | 1 |
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