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| 1 | Hepatic fibrosis: It is time to go with hepatic stellate cell-specifictherapeutic targets显示文摘Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix(ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases. Phenotypic activation of hepatic stellate cells(HSC) plays a central role in the progression of hepatic fibrosis. Retardation of proliferation and clearance of activated HSCs from the injured liver is an appropriate therapeutic strategy for the resolution and treatment of hepatic fibrosis. Clearance of activated HSCs from the injured liver by autophagy inhibitors, proapoptotic agents and senescence inducers with the high affinity toward the activated HSCs may be the novel therapeutic strategy for the treatment of hepatic fibrosis in the near future. | Devaraj Ezhilarasan Etienne Sokal Mustapha Najimi | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 56 |
| 2 | 液相色谱-串联质谱法测定辣木及萝卜叶的提取物中所含的槲皮素、芦丁及山柰酚(英文)显示文摘目的:通过一种快速、敏感的液相色谱-串联质谱法测定辣木(Moringa oleifera Lam.)及萝卜(Raphinus sativus Linn.)叶的提取物中所含的槲皮素、芦丁及山柰酚。方法:使用冷浸法(90%乙醇)对辣木及萝卜叶进行提取。提取物与0.2%甲酸和氰化甲烷混合后以0.4mL/min的速度通过Phenomenex Gemini C18色谱层析柱,通过时间为5.01min。结果:串联质谱法测定的离子转换分别为槲皮素303.03~153.1,芦丁611.1~303.1,山柰酚287.1~153.2,内参180.1~110.1。对槲皮素、芦丁及山柰酚定量测量的最低浓度为5ng/mL,线性分布为5~2000ng/mL。槲皮素、芦丁及山柰酚的线性回归系数分别为0.9946、0.9951及0.9969。结论:本研究的结果证明了液相色谱-串联质谱法具有快速、灵敏的特点,对于同时测定辣木及萝卜叶的提取物中所含的槲皮素、芦丁及山柰酚有较好的特异性。 | Venkatapura C. Devaraj Burdipad G. Krishna Gollapalle L. Viswanatha | 2011 | 中西医结合学报2011，9，9： | 8 |
| 3 | Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression显示文摘BACKGROUND: Proliferation of hepatic stellate cells(HSCs) plays a pivotal role in the progression of liver fibrosis consequent to chronic liver injury. Silibinin, a flavonoid compound,has been shown to possess anti-fibrogenic effects in animal models of liver fibrosis. This was attributed to an inhibition of cell proliferation of activated HSCs. The present study was to gain insight into the molecular pathways involved in silibinin anti-fibrogenic effect. METHODS: The study was conducted on LX-2 human stellate cells treated with three concentrations of silibinin(10, 50 and 100 μmol/L) for 24 and 96 hours. At the end of the treatment cell viability and proliferation were evaluated. Protein expression of p27, p21, p53, Akt and phosphorylated-Akt was evaluated by Western blotting analysis and Ki-67 protein expression was by immunocytochemistry. Sirtuin activity was evaluated by chemiluminescence based assay. RESULTS: Silibinin inhibits LX-2 cell proliferation in doseand time-dependent manner; we showed that silibinin upregulated the protein expressions of p27 and p53. Such regulation was correlated to an inhibition of both downstream Akt and phosphorylated-Akt protein signaling and Ki-67 protein expression. Sirtuin activity also was correlated to silibinininhibited proliferation of LX-2 cells. CONCLUSION: The anti-proliferative effect of silibinin on LX-2 human stellate cells is via the inhibition of the expressions of various cell cycle targets including p27, Akt and sirtuin signaling. | Devaraj Ezhilarasan Jonathan Evraerts Brice Sid Pedro Buc Calderon Sivanesan Karthikeyan Etienne Sokal Mustapha Najimi | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 7 |
| 4 | Anti-inflammatory activity of Alpinia officinarum hance on rat colon inflammation and tissue damage in DSS induced acute and chronic colitis models显示文摘The purpose of this study was to investigate the possible prophylactic effects of Alpinia officinarum hance on experimentally induced acute and chronic colitis models,in-vivo and in-vitro.Acute and chronic colitis were induced in Male Wistar rats by administration of Dextran Sulfate Sodium(DSS)in drinking water.DSS induction exhibited colon shrinkage,increased the Disease Activity Index(DAI)score,increased the levels of inflammatory markers and caused severe anemia.DSS induced animals,co-treated with the hexane extract of Alpinia officinarum(HEAO)(200 mg/kg body wt),effectively suppressed colonic injury that was evidenced by the reduced DAI score,colon weight/length ratio,histological damage,proinflammatory markers and MPO activity.Further,it restored the colonic antioxidants near to normal levels by regulating the oxidative stress via attenuation of lipid peroxidation.Our results revealed that the degree of colitis caused by the administration of DSS was significantly attenuated by HEAO.In addition,the in-vitro study showed that HEAO treatment inhibited the proliferation of HT-29 cells and down regulated the mRNA expression of NF-B and COX-2.Taken together,these results suggest that HEAO is a promising anti-oxidant and anti-inflammatory agent that support its possible therapeutic role in the treatment of colitis. | Vijayabharathi Rajendiran Vidhya Natarajan Sivasithamparam Niranjali Devaraj | 2018 | Food Science and Human Wellness2018，7，4： | 5 |
| 5 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 6 | Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases显示文摘Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are less fibrogenic, migratory, and also have less proliferative potential. However, activated HSCs(a HSCs) are more fibrogenic and have a high migratory and proliferative MFBs phenotype. HSCs activation is a highly energetic process that needs abundant intracellular energy in the form of adenosine triphosphate(ATP) for the synthesis of extracellular matrix(ECM) in the injured liver to substantiate the injury. Data sources: The articles were collected through Pub Med and EMBASE using search terms 'mitochondria and hepatic stellate cells', 'mitochondria and HSCs', 'mitochondria and hepatic fibrosis', 'mitochondria and liver diseases', and 'mitochondria and chronic liver disease', and relevant publications published before September 31, 2020 were included in this review. Results: Mitochondria homeostasis is affected during HSCs activation. Mitochondria in a HSCs are highly energetic and are in a high metabolically active state exhibiting increased activity such as glycolysis and respiration. a HSCs have high glycolytic enzymes expression and glycolytic activity induced by Hedgehog(Hh) signaling from injured hepatocytes. Increased glycolysis and aerobic glycolysis(Warburg effect) endproducts in a HSCs consequently activate the ECM-related gene expressions. Increased Hh signaling from injured hepatocytes downregulates peroxisome proliferator-activated receptor-γ expression and decreases lipogenesis in a HSCs. Glutaminolysis and tricarboxylic acid cycle liberate ATPs that fuel HSCs to proliferate and produce ECM during their activation. Conclusions: Available studies suggest that mitochondria functions can increase in parallel with HSCs activation. Therefore, mitochondrial modulators should be tested in an elaborate manner to control or prevent the HSCs activation during liver injury to subsequently regress hepatic fibrosis. | Devaraj Ezhilarasan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 7 | Critical role of estrogen in the progression of chronic liver diseases显示文摘Background:Estrogens regulate sexual function and also have a significant role in various pathophysiological processes.Estrogens have a non-reproductive role as the modulators of the immune system,growth,neuronal function,and metabolism.Estrogen receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic dysfunctions.The purpose of the current review is to discuss the disparity role of estrogens on several forms of liver diseases.Data sources:A comprehensive search in PubMed and EMBASE was conducted using the keywords“estrogens and liver diseases”,“estradiol and liver diseases”,“hormones and liver diseases”,“endocrine function in liver diseases”,and“female hormones in liver diseases”.Relevant papers published before September 30,2019 were included.Results:The present review confirms the imperative role of estrogen in various forms of chronic liver diseases.Estrogens play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal individuals.In contrast,clinical studies also showed increased estrogen levels with chronic liver diseases.Conclusions:Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat models.However,in a few clinical studies,increased estrogen levels are also implicated in chronic liver diseases.Therefore,further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases. | Devaraj Ezhilarasan | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 4 |
| 8 | Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H_(2)O_(2) LDL induced Human Peripheral Blood Mononuclear Cells(PBMC)显示文摘Cymbopogon citratus(lemon grass)is commonly used in traditional folk medicine.The essential oil extracted from C.citratus has been reported as a potential anti-oxidant and anti-inflammatory agent.This study has been designed to explore the protective effect of C.citratus(lemon grass)against modified LDL(OxLDL and H2O2 LDL)induced cytotoxicity in Peripheral Blood Mononuclear Cells(PBMC).The essential oil extracted from C.citratus(EOC)was subjected to FT-IR spectroscopic analysis for the identification of functional groups.In vitro antioxidant assays were carried out to assess the electron donating capability of EOC as compared with a known standard L-ascorbic acid.The cytoprotective effects of EOC were determined in PBMC induced with modified LDL.Spectra obtained from FT-IR analysis showed the presence of functional groups in EOC such as H-bonded,O-H stretching,N-H stretching,aldehyde-C-H stretching,aldehyde/ketone-C=O stretching,-C=C-stretching,-CH_(3) bending,-C-H in plane bending.EOC has greater antioxidant property when compared with the standard L-ascorbic acid.EOC at all test concentrations demonstrated free radical scavenging activity and cytoprotective effect when challenged against modified LDL in PBMC.The above results show EOC as a promising antioxidant and cytoprotective agent. | S.Jamuna Sakeena Sadullah M.S. R.Ashokkumar Gokul Shanmuganathan Senguttuvan Sivan Mozhi Niranjali Devaraj S. | 2017 | Food Science and Human Wellness2017，6，2： | 3 |
| 9 | Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role显示文摘 | Senthil Kumar Venugopal Sridevi Devaraj Ishwarlal Jialal | 2005 | Current Opinion in Nephrology and Hypertension2005，，1： | 3 |
| 10 | Active catalytic species generated in situ in zirconia incorporated hydrogen storage material magnesium hydride显示文摘This study explores how zirconia additive interacts with MgH_(2)to improve its hydrogen storage performance.Initially it is confirmed that the zirconia added MgH_(2)powder releases hydrogen at a temperature of about 50℃below that of the additive free MgH_(2).Subsequent tests by X ray diffraction(XRD)and infrared(IR)spectroscopy techniques reveal that the ZrO_(2) mixed MgH_(2)powder contains ZrHx(21.5)and MgO secondary phases.This observation is supported by the negative Gibbs free energy values obtained for the formation of ZrH_(2)/MgO from ZrO_(2)/MgH_(2)powder samples.An X ray photoelectron spectroscopy(XPS)study reveals that apart from Zr^(4+)cations,Zr^(2+) and zero valent Zr exist in the powder.Atomic force microscopy(AFM)study reveals that the average grain size is 20 nm and the elemental line scan profiles further proves the existence of oxygen deficient Zr bearing phase(s).This study strengthens the belief that functional metal oxide additives in fact chemically interact with MgH_(2)to make active in-situ catalysts in the MgH_(2)system. | D.Pukazhselvan K.S.Sandhya Devaraj Ramasamy Aliaksandr Shaula Igor Bdikin Duncan Paul Fagg | 2022 | Journal of Magnesium and Alloys2022，10，3： | 3 |
| 11 | 苋科植物雁来红叶提取物对大鼠的胃细胞保护及抗分泌作用(英文)显示文摘目的:验证苋科植物雁来红(Amaranthustricolor Linn.)叶的提取物对不同胃溃疡模型大鼠的抗溃疡作用。方法:通过5种不同的大鼠胃溃疡模型(乙酸、幽门结扎、乙醇、消炎痛及缺血再灌注模型)证实雁来红叶对大鼠胃分泌功能的影响及胃细胞的保护作用。不同的雁来红叶的提取物(乙醇、石油醚、三氯甲烷及乙酸乙酯)以200mg/kg的剂量给予大鼠服用以检测其功效。结果:急性口服毒性实验显示各种提取物的安全口服剂量可达2000mg/kg,故选取该剂量的十分之一即200mg/kg作为实验用剂量。乙醇提取物及乙酸乙酯提取物对乙酸所致大鼠慢性胃溃疡有治愈作用;对幽门结扎大鼠有抑制其胃分泌功能的作用;对乙醇及消炎痛所致胃溃疡大鼠有胃细胞保护作用。而石油醚及三氯甲烷提取物没有明显的抗大鼠胃溃疡的作用。结论:本研究证明雁来红叶的提取物对实验性大鼠胃溃疡有很好的治疗作用,这一作用与文献所报道的该植物在民间医学中的应用相符。 | Venkatapura C. Devaraj Burdipad G. Krishna | 2011 | 中西医结合学报2011，9，9： | 2 |
| 12 | C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells: Implications for the Metabolic Syndrome and Atherothrombosis显示文摘 | Sridevi Devaraj Dan Yan Xu Ishwarlal Jialal | 2003 | Circulation: Journal of the American Heart Association2003，，3： | 2 |
| 13 | C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype显示文摘 | Sridevi Devaraj Ishwarlal Jialal | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，6： | 2 |
| 14 | Performance impacts of information technology:Is actual usage the missing link?显示文摘 | DEVARAJ S KOHLI R | 2003 | Management Science2003，49，3： | 1 |
| 15 | Reactive protein increase plasm inogen activator inhibitorl expression and activity in human a orticendo the lialcells:implications for the metabolic syndrome and a therothrombosis显示文摘 | Devaraj S Xu DY Jialall C | 2003 | Circulation2003，107，3： | 1 |
| 16 | C-reactive protein decreases endothelial nitric ox-ide synthase activity via uncoupling显示文摘 | SINGH U DEVARAJ S VASQUEZ-VIVAR J etal | 2007 | J Mol CellCardiol2007，43，： | 1 |
| 17 | Quantitative essential amino acid requirements for growth of catla,Catla catla(Hamilton)显示文摘 | Ravi J Devaraj K V | 1991 | Aquaculture1991，96，： | 1 |
| 18 | Inflammation and atherosclerosis:The value of the high-sensitivity C-reactive protein assay as a risk marker显示文摘 | Jialal I Devaraj S | 2001 | Am J Clin Pathol2001，，： | 1 |
| 19 | Inflammation and atherosclerosis:the value of the highsensitive creative protein assay as a risk marker显示文摘 | Jialal I Devaraj S | 2001 | Am J Cli Pathol2001，，： | 1 |
| 20 | Direct demonstration of an antiinflammatory effect of Simvastatin in subjects with the Metabol- ic syndrome显示文摘 | DEVARAJ S CHAN E JIALAL I | 2006 | Journal of Clinical Endocrinology & Metabolism2006，91，11： | 1 |
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