|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements显示文摘Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating factors.Each of the various strategies currently employed to face these scourges is seriously inadequate.Despite enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented.Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden.Nowadays,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently used.The recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease. | Denis Zofou Raymond B Nyasa Dickson S Nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete | 2014 | Infectious Diseases of Poverty2014，3，1： | 4 |
| 3 | Correlation between water diffusion and adhesion loss: Study of an epoxy primer on steel显示文摘 | Elise Legghe Emmanuel Aragon Léna?k Bélec André Margaillan Denis Melot | 2009 | Progress in Organic Coatings2009，，3： | 2 |
| 4 | Experimental study of pulse-jet cleaning of bag filters supported by rigid rings显示文摘 | Xavier Simon Sandrine Chazelet Dominique Thomas Denis Bémer Roland Régnier | 2006 | Powder Technology2006，，2： | 2 |
| 5 | 快速凝固富钛Ti-V合金的微观组织和储氢性能(英文)显示文摘研究目的在于优化Ti0.8-0.9V0.2-0.1二元合金的相结构成分、微观组织和储氢性能。该合金主要用于从含有大量一氧化碳的高温气态混合物中吸收氢气。Ti0.8-0.9V0.2-0.1合金中的α-(HCP)和β-(BCC)相在纯氢气中基于氢化作用,形成单相FCC结构的氢化物,此过程与合金的化学成分无关。同步辐射X射线衍射的原位分析表明,在含有氢气和10%一氧化碳的混合气体中,只有β相转变成相应的氢化物。快速凝固(RS)处理细化了Ti0.8V0.2和Ti0.9V0.1合金的晶粒组织,而且,快速凝固处理增加了Ti0.9V0.1合金中的β相,其所占比例是普通熔铸条件下的两倍。扫描电子显微镜(SEM)分析表明,Ti0.9V0.1合金含有片状组织,层片的厚度约为300nm。热脱附谱(TDS)显示,微观组织的细化可以加快氢脱附的动力学过程。 | Suwarno SUWARNO Jan Ketil SOLBERG Jan Petter MAEHLEN Bente KROGH Bφrre Tore BφRRESEN Esther OCHOA-FERNANDEZ Erling RYTTER Mario WILLIAMS Roman DENYS Volodymyr A.YARTYS | 2012 | Transactions of Nonferrous Metals Society of China2012，22，8： | 2 |
| 6 | Transformation kinetics and microstructures of Ti17 titanium alloy during continuous cooling显示文摘 | TEIXEIRA J APPOLAIRE B AEBY-GAUTIER E DENIS S CAILLETAUD G SPAAETH N | 2007 | Materials Science and Engineering A2007，448，12： | 1 |
| 7 | The effect of incentive policies on the practice location of doctors: a multinomial Probit analysis 显示文摘 | Denis B Fortin B Fournier M | 1996 | J Labor Economics1996，14，4： | 1 |
| 8 | Improvement of diosgenin yield from Dioscorea deltoidea plant cell cultures by use of a non-traditional hydrolysis method显示文摘 | Denis D Yves S Harvey W B | 1986 | Planta Medica1986，，6： | 1 |
| 9 | An application of multivariate simulation in the cement industry显示文摘 | Denis M Keyvan M Claude B | 2005 | Mathematical Geology2005，37，5： | 1 |
| 10 | Robust stabilization of diserete-time linear systems with norm bounded time- varying uncertainty 显示文摘 | Germain G Jacqucs B Denis A | 1994 | Systems and Control Lieuers1994，22，5： | 1 |
| 11 | Product and Service Delivery Satisfaction among North American Cruise Passengers 显示文摘 | Victor B Teye Denis Leclerc | 1998 | Tourism Management1998，，19： | 1 |
| 12 | Wavelet transform domain filters:a spatially selective noise filtration technique 显示文摘 | Xu Y S John B W Denis M H | 1994 | Trans on Image Processing1994，3，6： | 1 |
| 13 | Cellular physiology of cholesterol efflux in vascular endothelial cells 显示文摘 | O'Connell B J Denis M Genest J | 2004 | Circulation2004，110，18： | 1 |
| 14 | Absolute radiometric calibration of the RapidEye multispectral imager using the reflectance-based vicarious calibration method显示文摘 | DENIS N ANDREAS B JEFF C M | | 0，，： | 1 |
| 15 | Policies and struc- tures for spinning off new companies from research and de- velopment organizations 显示文摘 | ROBERTS E B DENIS E MALONET | 1996 | R&D Management1996，26，： | 1 |
| 16 | Genetic differences for nitrogen uptake and nitrogen utilisation efficiencies in winter wheat显示文摘 | Jacques Le Gouis Denis Béghin Emmanuel Heumez Pierre Pluchard | 2000 | European Journal of Agronomy2000，，3： | 1 |
| 17 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 18 | The King V curve pattern: its analysis and surgical treatment显示文摘 | Winter R B Denis F | 1994 | Orthop Clin North Am1994，25，： | 1 |
| 19 | Robust stabilization of dise- rete time linear system: with norm bounded time-varying uncertainty显示文摘 | Gerrnain G Jacqucs B Denis A | 1994 | Systems and Control Lieuers1994，22，5： | 1 |
| 20 | Metabolic counterpart of de- creased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study 显示文摘 | Nicoli F Lefur Y Denis B | 2003 | Stroke2003，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员