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| 1 | Adult neural stem cells in the mammalian central nervous system显示文摘神经干细胞(NSC ) 不仅在胚胎的发展期间而且在所有哺乳动物的种类的成年大脑是在场的,包括人。在 vivo 的干细胞壁龛建筑学使成年 NSC 能连续地在整个生活在特定的大脑区域产生功能的神经原。成年神经发生过程服从于动态规定由各种各样生理,病理学并且药理学刺激。Multipotent 成年 NSC 也看起来内在地塑料,对基因编程顺从在正常区别期间,并且到 epigenetic reprograming 在进 pluripotency 的 de 区别期间。增加的证据建议成年 NSC 显著地在生理、病理学的条件下面贡献专业化神经功能。充分理解成年 NSC 的生物学将提供关键卓见进病原学和主要大脑混乱的潜在的治疗学的干预。这里,我们在哺乳动物的中央神经系统的成年 NSC 上考察最近的进步,包括他们在癌症和再生药的身份,壁龛,功能,粘性,和新兴的角色上的话题。 | Dengke K Ma | 2009 | Cell Research2009，19，6： | 35 |
| 2 | Exact solutions for the flow of non-Newtonian fluid with fractional derivative in an annular pipe显示文摘This paper deals with some unsteady unidirectional transient flows of Oldroyd-B fluid in an annular pipe. The fractional calculus approach in the constitutive relationship model Oldroyd-B fluid is introduced and a generalized Jeffreys model with the fractional calculus has been built. Exact solutions of some unsteady flows of Oldroyd-B fluid in an annular pipe are obtained by using Hankel transform and Laplace transform for fractional calculus. The following four problems have been studied: (1) Poiseuille flow due to a constant pressure gradient; (2) axial Couette flow in an annulus; (3) axial Couette flow in an annulus due to a longitudinal constant shear; (4) Poiseuille flow due to a constant pressure gradient and a longitudinal constant shear. The well-known solutions for Navier-Stokes fluid, as well as those corresponding to a Maxwell fluid and a second grade one, appear as limited cases of our solutions. | TONG Dengke WANG Ruihe YANG Heshan | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，4： | 15 |
| 3 | Experimental study of effect of post processing on fracture toughness and fatigue crack growth performance of selective laser melting Ti-6Al-4V显示文摘For Ti-6Al-4V,a titanium alloy increasingly used in aerospace structure,selective laser melting(SLM)is an attractive additive manufacturing technology,which is attributed to its complex construction capability with high accuracy and good surface quality.In order to obtain qualified mechanical properties,SLM parameters and post processing should be tailored for diverse service conditions.Fracture toughness and fatigue crack growth(FCG)behavior are critical characteristics for damage tolerance evaluation of such metallic structures,and they are affected by post processing technologies significantly.The objective of this study is to obtain the fracture toughness and fatigue crack growth behavior of Ti-6Al-4V manufactured by SLM,and to evaluate the influence of post-SLM thermomechanical treatment and surface machining.Fracture toughness and FCG tests were performed for SLM Ti-6Al-4V in three types of post processing status:as-built,heat treated and hot isostatically pressed(HIPed),respectively.Specimens with as-built and machined surface were tested.The microstructure and fractography were analyzed as well in order to investigate the relevance among manufacture process,microstructure and mechanical properties.The results demonstrate that as-built SLM Ti-6Al-4V presents poor ductility and FCG behavior due to martensitic microstructure and residual stresses.Both heat treatment and hot isostatic pressing improve the plane-stress fracture toughness and FCG performance considerably,while surface machining shows slight effect. | Haiying ZHANG Dengke DONG Shaopu SU An CHEN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 13 |
| 4 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 5 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 6 | Analysis of the flow of non-Newtonian viscoelastic fluids in fractal reservoir with the fractional derivative显示文摘In this paper, fractional order derivative, fractal dimension and spectral dimension are introduced into the seepage flow mechanics to establish the relaxation models of non-Newtonian viscoelastic fluids with the fractional derivative in fractal reservoirs. A new type integral transform is introduced, and the flow characteristics of non-Newtonian viscoelastic fluids with the fractional order derivative through a fractal reservoir are studied by using the integral transform, the discrete Laplace transform of sequential fractional derivatives and the generalized Mittag-Leffler function. Exact solutions are obtained for arbitrary fractional order derivative. The long-time and short-time asymptotic solutions for an infinite formation are also obtained. The pressure transient behavior of non-Newtonian viscoelastic fluids flow through an infinite fractal reservoir is studied by using the Stehfests inversion method of the numerical Laplace transform. It is shown that the clearer the viscoelastic characteristics of the fluid, the more the fluid is sensitive to the order of the fractional derivative. The new type integral transform provides a new analytical tool for studying the seepage mechanics of fluid in fractal porous media. | TONG Dengke WANG Ruihe | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，4： | 10 |
| 7 | Cloned pigs derived from somatic cell nuclear transferembryos cultured in vitro atlow oxygen tension显示文摘Pig cloning has great potential to human xenotransplantation. The present study was designed to establish a more efficient system for producing cloned pigs by somatic cell nuclear transfer (SCNT). Our approach was as follows: SCNT embryos were reconstructed by using fetal fibroblasts of Chinese miniature pig as donors and in vitro matured oocytes of prepubertal gilts as recipients. Reconstructed em- bryos were induced by electrical fusion/activation and cultured in BSA-containing North Carolina State University 23 medium (NCSU-23) or Porcine Zygote Medium (PZM-3) at the gas condition of 5% CO2, 7% O2, 88% N2. A total of 230 cloned embryos were transferred to three surrogate sows, producing three piglets. One of them is apparently healthy. The clonal provenance of the piglet was indicated by its coat color and confirmed by DNA microsatellite analysis. These results indicate that the use of in vitro matured oocytes from prepubertal gilts as recipient, combined with cloned embryos cultured at low oxygen tension is an effective way to produce cloned pigs. | PAN Dengke ZHANG Yunhai SUN Xiuzhu ZHANG Jian LI Xuyang LI Yan GU Zhiliang DA Yunping WU Changxin LI Ning | 2006 | Chinese Science Bulletin2006，51，7： | 8 |
| 8 | Degradation of 4-nitrophenol by electrocatalysis and advanced oxidation processes using Co3O4@C anode coupled with simultaneous CO2 reduction via SnO2/CC cathode显示文摘Herein,we prepa red novel three-dimensional(3D)gear-s haped Co3O4@C(Co3O4 modified by amorphous carbon)and sheet-like SnO2/CC(SnO2 grow on the carbon cloth)as anode and cathode to achieve efficient removal of 4-nitrophenol(4-NP)in the presence of peroxymonosulfate(PMS)and simultaneous electrocatalytic reduction of CO2,respectively.In this process,4-NP was mineralized into CO2 by the Co3O4@C,and the generated CO2 was reduced into HCOOH by the sheet-like SnO2/CC cathode.Compared with the pure Co0.5(Co3O4 was prepared using 0.5 g urea)with PMS(30 mg,0.5 g/L),the degradation efficiency of 4-NP(60 mL,10 mg/L)increased from 74.5%-85.1%in 60 min using the Co0.5 modified by amorphous carbon(Co0.5@C).Furthermore,when the voltage of 1.0 V was added in the anodic system of Co0.5@C with PMS(30 mg,0.5 g/L),the degradation efficiency of 4-NP increased from 85.1%-99.1%when Pt was used as cathode.In the experiments of 4-NP degradation coupled with simultaneous electrocatalytic CO2 reduction,the degradation efficiency of 4-NP was 99.0%in the anodic system of Co0.5@C with addition of PMS(30 mg,0.5 g/L),while the Faraday efficiency(FE)of HCOOH was 24.1%at voltage of-1.3 V using the SnO2/CC as cathode.The results showed that the anode of Co3O4 modified by amorphous carbon can markedly improve the degradation efficiency of 4-NP,while the cathode of SnO2/CC can greatly improve the FE and selectivity of CO2 reduction to HCOOH and the stability of cathode.Finally,the promotion mechanism was proposed to explain the degradation of organic pollutants and reduction of CO2 into HCOOH in the process of electrocatalysis coupled with advanced oxidation processes(AOPs)and simultaneous CO2 reduction. | Meng Zhu Longshuai Zhang Shanshan Liu Dengke Wang Yuancheng Qin Ying Chen Weili Dai Yuehua Wang Qiuju Xing Jianping Zou | 2020 | Chinese Chemical Letters2020，31，7： | 7 |
| 9 | Niobium alloying effect in high carbon equivalent grey cast iron显示文摘The effect of niobium on the formation of NbC phase and solidification structure in high carbon equivalent grey cast iron was investigated.The experimental results indicated that an increase in the niobium content is favorable to refining the graphite and eutectic cell;and the pearlite lamellar spacing is reduced.Based on the thermodynamic calculation the formation of NbC is prior to the eutectic reaction.The reduction in the pearlite lamellar spacing is mainly attributed to the decrease of eutectic temperature with the addition of niobium.Additionally,properties including hardness and wear resistance were improved after the addition of niobium. | Zhou Wenbin Zhu Hongbo Zheng Dengke Zheng Hongxing Hua Qin Zhai Qijie | 2011 | China Foundry2011，8，1： | 7 |
| 10 | Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis显示文摘Background:Due to the high prevalence and complex etiology,bovine mastitis(BM)is one of the most important diseases to compromise dairy cow health and milk quality.The shift in milk compositions has been widely investigated during mastitis,but recent studies suggested that gastrointestinal microorganism also has a crucial effect on the inflammation of other peripheral tissues and organs,including the mammary gland.However,research focused on the variation of rumen inner-environment during mastitis is still limited.Therefore,the ruminal microbial profiles,metabolites,and milk compositions in cows with different udder health conditions were compared in the present study.Furthermore,the correlations between udder health status and ruminal conditions were investigated.Based on the somatic cell counts(SCC),California mastitis test(CMT)parameters and clinical symptoms of mastitis,60 lactating Holstein dairy cows with similar body conditions(excepted for the udder health condition)were randomly divided into 3 groups(n=20 per group)including the healthy(H)group,the subclinical mastitis(SM)group and the clinical mastitis(CM)group.Lactation performance and rumen fermentation parameters were recorded.And rumen microbiota and metabolites were also analyzed via 16S rRNA amplicon sequencing and untargeted metabolomics,respectively.Results:As the degree of mastitis increased,rumen lactic acid(LA)(P<0.01),acetate,propionate,butyrate,valerate(P<0.001),and total volatile fatty acids(TVFAs)(P<0.01)concentrations were significantly decreased.In the rumen of CM cows,the significantly increased bacteria related to intestinal and oral inflammation,such as Lachnospiraceae(FDR-adjusted P=0.039),Moraxella(FDR-adjusted P=0.011)and Neisseriaceae(FDR-adjusted P=0.036),etc.,were accompanied by a significant increase in 12-oxo-20-dihydroxy-leukotriene B4(FDR-adjusted P=5.97×10^(−9))and 10beta-hydroxy-6beta-isobutyrylfuranoeremophilane(FDR-adjusted P=3.88×10^(−10)).Meanwhile,in the rumen of SM cows,the Ruminiclostridium_9(FDR-adjusted P=0.042)and Enterorhabdus(FDR-adjusted P=0.043)were increased along with increasing methenamine(FDR-adjusted P=6.95×10^(−6)),5-hydroxymethyl-2-furancarboxaldehyde(5-HMF)(FDR-adjusted P=2.02×10^(−6))and 6-methoxymellein(FDR-adjusted P=2.57×10^(−5)).The short-chain fatty acids(SCFAs)-producing bacteria and probiotics in rumen,including Prevoterotoella_1(FDRadjusted P=0.045)and Bifidobacterium(FDR-adjusted P=0.035),etc.,were significantly reduced,with decreasing 2-phenylbutyric acid(2-PBA)(FDR-adjusted P=4.37×10^(−6)).Conclusion:The results indicated that there was a significant shift in the ruminal microflora and metabolites associated with inflammation and immune responses during CM.Moreover,in the rumen of cows affected by SM,the relative abundance of several opportunistic pathogens and the level of metabolites which could produce antibacterial compounds or had a competitive inhibitory effect were all increased. | Yue Wang Xuemei Nan Yiguang Zhao Linshu Jiang Mengling Wang Hui Wang Fan Zhang Fuguang Xue Dengke Hua Jun Liu Junhu Yao Benhai Xiong | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 11 | The coalbed methane transport model and its application in the presence of matrix shrinkage显示文摘Based on the theories of surface physical chemistry, theoretical formulations for permeability and porosity are presented which include both stress effect and matrix shrinkage in a single equation. Then, a three-dimensional, dual porosity, nonequilibrium adsorption, pseudosteady state mathematical model for gas and water is established and solved by the fully implicit method and the block precondition- ing orthomin algorithm. A history matching for the Qinshui Well TL003 is done. From the results, it is shown that the obvious enhancement of permeability occurs along with the passing time but the reservoir pressure of 15# coal seam cannot fulfill the critical adsorption pressure as a result of the water recharge of the aquifer. Hence, it is suggested to plug the 15# coal seam. | ZHANG XianMin TONG DengKe | 2008 | Science China(Technological Sciences)2008，51，7： | 5 |
| 12 | The influence of Zr substitution for Nb on the corrosion behaviors of the Ni-Nb-Zr bulk metallic glasses显示文摘The influence of Zr content on corrosion behaviors of the Ni61.5Nb 38.5xZrx(x=1,3,5,7,9 at.%) bulk metallic glasses(BMGs) in 1 M HCl aqueous solution was investigated by potentiodynamic polarization measurements and X-ray photo-electron spectroscopy(XPS).It was found that these BMG alloys possess superior corrosion resistance,that is,with large passive region of about 1.5 V and low passive current density(as low as 0.05 Am-2 for Ni61.5Nb31.5Zr7).XPS analysis indicates that the high corrosion resistance is attributed to the formation of Nb-and Zr-enriched surface films formed in the aggressive acid solution.The Zr substitution for Nb effectively reduces the Ni content,particularly the metallic state Ni content in the surface films,which depresses the electrical conduction of the surface films and reduces the passive current density,thus leading to the enhancement of the corrosion resistance of these Ni-Nb-Zr BMGs.These alloys may potentially be useful for engineering applications. | LI DengKe ZHU ZhengWang ZHANG HaiFeng WANG AiMin HU ZhuangQi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 5 |
| 13 | Effect of Sn addition on the glass-forming ability and mechanical properties of Ni-Nb-Zr bulk metallic glasses显示文摘The effect of tin (Sn) addition on the glass forming ability (GFA) and mechanical properties of the Ni-Nb-Zr ternary alloy system has been studied. The addition of Sn improves the GFA; Ni61Nb35.5-xZr3.5Snx (in at.%) alloys with x=1 can be cast into amorphous samples at least 3 mm in diameter using a copper mold injection-casting method. The critical size for glass formation decreases to 2 mm when x=5 because Ni2SnZr phase precipitates readily. The addition of Sn is also effective in enhancing the stability of the supercooled liquid; a maximum supercooled liquid region of 48 K was attained for the Ni61Nb30.5Zr3.5Sn5 alloy. Compression tests reveal that the Ni61Nb33.5Zr3.5Sn2 alloy possesses the best mechanical properties,with yield strength~3180 MPa,fracture strength~3390 MPa and plastic strain ~1.3%. The fracture surfaces examined by scanning electron microscopy indicate that the alloys have a transition from ductility to brittleness in fracture behavior. The combination of high GFA,high thermal stability,high strength and compressive plasticity makes these alloys potentially attractive for engineering applications. | LI DengKe ZHANG HaiFeng WANG AiMin ZHU ZhengWang HU ZhuangQi | 2011 | Chinese Science Bulletin2011，56，36： | 5 |
| 14 | Synthesis and characterization of magnesium hydroxide by batch reaction crystallization显示文摘Magnesium hydroxide with high purity and uniform particle size distribution was synthesized by the direct precipitation method using MgCl_(2) and NaOH as reactive materials and NaCl as additive to improve the crystallization behavior of the product.The particle size distribution,crystal phase,morphology,and surface area of magnesium hydroxide were characterized by Malvern laser particle size analyzer,X-ray diffraction(XRD),scanning electron microscope(SEM)and Branauer-Emmett-Teller(BET)method,respectively.The purity of products was analyzed by the chemical method.The effects of synthesis conditions on the particle size distribution and water content(filtration cake)of magnesium hydroxide were investigated.The results indicated that feeding mode and rate,and reaction temperature had important effects on water content and the particle size distribution of the product,and sodium chloride improved the crystallization behavior of magnesium hydroxide.The ball-like magne-sium hydroxides with the particle size distribution of 6.0–30.0μm and purity higher than 99.0%were obtained.This simple and mild synthesis method was promising to be scaled up for the industrial production of magnesium hydroxide. | Xingfu SONG Shuying SUN Dengke ZHANG Jin WANG Jianguo YU | 2011 | Frontiers of Chemical Science and Engineering2011，5，4： | 4 |
| 15 | VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration显示文摘Dear Editor, Mitochondrial complex I is important for cellular ATP producti on by tran sporti ng electro ns and gen erati ng proton gradient across the mitochondrial inner membrane (Hirst, 2013). It is also a major cellular locus where electron leakage to oxygen produces superoxide, an ROS (reactive oxygen species), particularly under oxidative stress conditions. Dysfunctional complex I contributes to the most comm on oxidative phosphorylation disorder in humans, with many iden tified gen etic mutati ons in complex I sub units causing a variety of human disorders including Leigh syndrome, encephalomyopathy, cardiomyopathy, parkinsonism and hereditary optic neuropathy (Hirst, 2013;Guo et al., 2017). In addition, complex I is the major target of many parkinsonismcausing neurotoxins including rotenone and MPTP. Past biochemical, cell biological and structural studies have elucidated how complex I functions normally in mitochondrial respiration (Hirst, 2013;Guo et al., 2017;Letts and Sazanov, 2017). Nonetheless, our understanding of mechanisms how complex I dysfunction leads to human diseases is far from completion;therapeutic targets and strategies are urgently needed. | Song Chen Shuo Luo Zhe Zhang Dengke K. Ma | 2019 | Protein & Cell2019，10，8： | 3 |
| 16 | Trends on physical understanding of bioink printability显示文摘Recently, 3D bioprinting is developed as an emerging approach, increasingly applied to materials for healthcare;while, the precise placement of cells and materials, and the shape fidelity of forming constructs is of great importance for successful application of 3D bioprinting. Research efforts have been made to develop new bioinks as 'raw materials' with better biocompatibility and biofunctionality, but the printability of bioinks is largely ignored and still needs to be carefully examined to enable robotic bioprinting. This article aims to introduce a recent published review (Appl. Phys. Rev. 2018, 5, 041304) on the evaluation of bioink printability by Huang's research group from University of Florida. Huang et al. comprehensively reviewed the bioink printability based on the physical point of view during inkjet printing, laser printing, and microextrusion, and a series of self-consistent time scales and dimensi on less quantities were utilized to physically understand and evaluate bioink printability. This article would be helpful to know the trends on physical understanding of bioink printability. | Jun Yin Dengke Zhao Jingyi Liu | 2019 | Bio-Design and Manufacturing2019，2，1： | 2 |
| 17 | 血压和血氧感受的分子调节机制及临床意义显示文摘机体的正常运作需要血压和血氧浓度维持在一定范围。短暂性异常水平的血压和血氧通过特异的感受器形成负反馈,从而使得机体维持正常的血压和血氧浓度。调节血压的神经元细胞感受器主要位于主动脉弓(aortic arch)和颈动脉窦(carotid sinus),通过延髓的运动中枢来调节血管收缩。肾脏的球旁细胞(juxtaglomerular cell)也能感受血压变化,通过释放肾素颗粒(renin)进入血液循环来调节血压。血氧的感受主要发生在颈动脉体(carotid body),通过延髓的运动中枢来快速调节呼吸和心率,而相对长期的血氧浓度维持和对低氧的适应是由EGLN氧气受体介导的。理解血压和血氧感受在正常和疾病条件下(比如高血压和脑卒中)的分子机制,对诸多心脑血管疾病的药物开发和临床应用具有重大的意义。本文介绍此领域的历史和研究进展,提出亟待解决的主要科学问题,并阐述这些进展和问题对与血压和血氧感受相关心脑血管疾病的临床意义。 | Dengke K.Ma | 2015 | 中华高血压杂志2015，23，5： | 2 |
| 18 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 19 | The coalbed methane transport mod- el and its application in the presence of matrix shrinkage 显示文摘 | Zhang Xianmin Tong Dengke | 2005 | Sci- ence in China Series E- Technological Sciences2005，51，： | 1 |
| 20 | Salidroside,the main active compound of rhodiola plants,inhibits high glucose induced me sangial cell proliferation显示文摘 | Dengke Yin Wenbing Yao Song Chen el al | 2009 | export planta medica2009，75，11： | 1 |
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