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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Endoscopic ultrasonography for the evaluation of smooth muscle tumors in the upper gastrointestinal tract: an experience with 42 cases显示文摘 | Tio TL Tytgat GNJ Den Hartog Jager FCA | 1990 | Gastrointest Endosc1990，36，4： | 2 |
| 3 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 4 | Follow-up of premalignant lesions in patients at risk for progression to gastric cancer显示文摘 | C. den Hoed I. Holster L. Capelle A. de Vries B. den Hartog F. ter Borg K. Biermann E. Kuipers | 2013 | Endoscopy2013，，04： | 2 |
| 5 | Asymptomatic Carotid Artery Stenosis: Identification of Subgroups with Different Underlying Plaque Characteristics显示文摘 | G.W. van Lammeren A.G. den Hartog G. Pasterkamp A. Vink J.-P.P.M. de Vries F.L. Moll G.J. de Borst | 2012 | European Journal of Vascular & Endovascular Surgery2012，，： | 2 |
| 6 | Serological markers of persistent,trachomatis in women with tubal factor subfertility显示文摘 | Den Hartog JE Land JA Stassen FR | 2005 | Hum Reprod2005，20，4： | 1 |
| 7 | Mechanical Vibrations显示文摘 | Den Hartog J P | 1956 | New York:McGraw-Hill BookCompany Inc 4Th ed1956，1956，： | 1 |
| 8 | Stentingversus surgery in patients with carotid stenosis afterprevious cervical radiation therapy : systematic reviewand meta-analysis显示文摘 | Fokkema M den Hartog AG Bots ML | 2012 | Stroke2012，43，3： | 1 |
| 9 | Effect of wheat cultivar and enzyme addition to broiler chicken diets on nutrient digestibility,performance,and apparent metabolizable energy content显示文摘 | Gutierrez del Alamo A Verstegen M W Den Hartog L A | 2008 | Poult Sci2008，87，4： | 1 |
| 10 | The serological gastric biopsy:a non-endoscopical diagnostic approach in management of the dyspeptic patient significance for primary care based on a survey of the literature显示文摘 | Korstanje A den Hartog G Biemond I | 2002 | Sc and J Gastroenterol2002，，： | 1 |
| 11 | The tumor spectrum in hereditary non-polyposis colorectal cancer:a study of 24 kindreds in the Netherlands显示文摘 | Vasen HF Offerhaus GJ den Hartog | 1990 | Int J Cancer1990，46，1： | 1 |
| 12 | Transmission line vibration due to sleet 显示文摘 | DEN HARTOG J P | 1932 | AIEE Transmission1932，51，4： | 1 |
| 13 | Transmission line vibration due to sleet显示文摘 | Den Hartog J P | 1932 | Trans AIEE1932，51，4： | 1 |
| 14 | Transmission line vibration due to sleet显示文摘 | Den Hartog J P | 1932 | Trans AIEE1932，51，4： | 1 |
| 15 | Flexor digitorum longus transfer with medial displacement calea- neal osteotomy : biomeehanieal rationale显示文摘 | Den Hartog BD | 2001 | Foot Ankle Clin2001，6，1： | 1 |
| 16 | Tumover of root-derived material and related microbial biomass formation in soils of different texture显示文摘 | Merckx R Den Hartog A Van Veen J | 1985 | Soil Biology and Biochemistry1985，17，4： | 1 |
| 17 | APC in flexible gastrointestinal endoscopy: pilot experiences 显示文摘 | Wahab PJ Mulder C J J den Hartog GD | 1997 | Endoscopy1997，29，： | 1 |
| 18 | Feed for Food:HACCP in the animal feed industry显示文摘 | Johan den Hartog | 2003 | Food control2003，14，： | 1 |
| 19 | When does Transformational Leadership Enhance Employee Proactive Behavior, the Role of Autonomy and Role Breadth Self-efficacy 显示文摘 | DEN HARTOG D N BELSCHAK F D | 2012 | Journal of Applied Psychology2012，97，1： | 1 |
| 20 | Primary shoulder arthmplasty versus conservative treatment for comminuted proximal humeral fractures : a systematic literature review 显示文摘 | den Hartog D de Haan J Sehep NW | 2010 | Open Orthop J2010，4，： | 1 |
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