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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Factors effecting the morphology of eudragit S-100 based microsponges bearing dicyclomine for colonic delivery 显示文摘 | Vikas J Deepika J Ranjit S | 2011 | J Pharmacol Sci2011，100，4： | 1 |
| 3 | Sperm-associated an-tigen 9 is a biomaker for early cervical carcinoma 显示文摘 | Manoj G Deepika K Salhan S | 2009 | Cancer2009，115，12： | 1 |
| 4 | Factors effecting the morphology of eudragit S-IO0 based microsponges bearing dicyclomine for colonic delivery 显示文摘 | Vikas J Deepika J Ranjit S | 2011 | J Pharmacol Sci2011，100，4： | 1 |
| 5 | Basin Geomorphology and Drainage Morphometry Parameters Used as Indicators for Groundwater Prospect: Insight from Geographical Information System(GIS) Technique显示文摘Influence of structural and lithological controls of various drainage patterns and their stream orientations(for 2nd, 3rd and 4th order steams) were identified to evaluate the direction and controlling factors of drainage network. To investigate the prospect of groundwater, hydrogeomorphological features of river basin viz. Mulki-Pavanje were identified and mapped. To evaluate the characteristics of the basin, different morphometric parameters(linear, areal and relief) were computed in sub-basin wise(SB-I to-VII). The linear parameters suggest drainage network is controlled by geomorphology. The form factor(Ff), elongation ratio(Re) and circularity ratio(Rc) suggest that the basin is in an elongated shape. The drainage density(Dd) indicates resistant/permeable strata under medium-dense vegetation with moderate relief. The areal parameters of the sub-basins(except SBI and Ⅲ) indicates moderate ground-slopes associated with moderately permeable rocks, which promote moderate run-off and infiltration. Drainage texture(T) of the whole basin indicates coarse texture while the SB-I, and Ⅲ showing an intermediate texture. The relief parameters namely ruggedness number(Rn) infers low basin relief and poor drainage density. To identify the most deficit/surplus zones of groundwater suitable weightages were assigned to the hydrogeomorphological units and morphometric parameters. The study reveal that the basin manifest that SB-Ⅲ shall be most deficit zone of groundwater, whereas SB-VII, VI and V are found to show increase in groundwater potentiality. Groundwater prospect area in this basin is estimated to be 7% area under poor, 44% area under moderate and 49% area under good to excellent. This paper demonstrated the potential application of geographical information system(GIS) techniques to evaluate the groundwater prospect in absence of traditional groundwater monitoring data. | Kumar Avinash B Deepika K S Jayappa | 2014 | Journal of Earth Science2014，25，6： | 1 |
| 6 | A comprehensive re- view on antimicrobial activity of 1,3,4-oxadiazole deriva- tives显示文摘 | Nupur J Arvind KS Deepika S | 2012 | Int Res J Pharm2012，3，3： | 1 |
| 7 | A comprehen- sive review on antimicrobial activity of 1,3,4-oxadiazole derivatives 显示文摘 | Nupur J Arvind K S Deepika S | 2012 | International Research Journal of Phar- macy2012，3，3： | 1 |
| 8 | Crystallization kinetics of CuxTi100-x(x=43,50 and 53) glasses显示文摘 | Rohit J Saxena N S Deepika B | 2001 | Physica B2001，301，： | 1 |
| 9 | Sperm-associated antigen 9 is a biomarker for early cervical carcinoma 显示文摘 | Manoj G Deepika K Salhan S | 2009 | Cancer2009，115，12： | 1 |
| 10 | Crystalli- zation kinetics of CurTitoo x (x=43, 50 and 53) glasses显示文摘 | ROHIT J SAXENA N S Deepika Bhandari | 2001 | Physica B2001，301，： | 1 |
| 11 | Fast disintegrating ta- blets: opportunity in drug delivery system显示文摘 | Parkash V Maan S Deepika | 2011 | J Adv Pha- rm Technol Res2011，2，4： | 1 |
| 12 | Annual report: surveillance of adverse events following immunisation in Australia, 2008显示文摘 | Rob Menzies Deepika Mahajan Michael S Gold et at | 2009 | Commun Dis Intell2009，33，4： | 1 |
| 13 | Superficial Temporal Fascia Pedicled V-Y Advancement Flap for Scalp Reconstruction 显示文摘 | Rohit S Deepika S Sengupta P | 2010 | J Maxillofac Oral Surg2010，9，4： | 1 |
| 14 | Paelitaxel and its formulations显示文摘 | Anil K S Alka G Deepika A | 2002 | Int J Pharm2002，235，122： | 1 |
| 15 | Quantitative thermal sensory testing in patients with amyotrophic lateral sclerosis u-sing reaction time exclusive method of levels (MLE)显示文摘 | Deepika J Manvir B Sumit S | 2006 | Electromyogr Clin Neurophysiol2006，46，3： | 1 |
| 16 | Down stream processing of stevioside and its potential applications 显示文摘 | Munish P Ashok T Deepika S | 2006 | Biotechnol Adv2006，426，： | 1 |
| 17 | Plasma Homocysteine level and its clinical correlation with type 2 diabetes mellitus and its complications显示文摘 | Satyendra K S Gyanendra K S Deepika S | 2014 | Inter J Diabetes in Developing Countries2014，34，1： | 1 |
| 18 | Management of chemotherapy-induced nausea and vomiting显示文摘 | Pooja D Swati S Deepika H | 2010 | Indian Pediatrics2010，47，2： | 1 |
| 19 | Sub-micron par- ticle number size distributions characteristics at urban location, Kan- put,in the Indo-Gangetie Plain显示文摘 | Kanawade V P Tripathi S N Deepika Bhattu | 2014 | Atmos Res2014，，： | 1 |
| 20 | Fast disintegrating tablets: Opportunity in drug delivery system 显示文摘 | PARKASH V MAAN S DEEPIKA | 2011 | J Adv Pharm Technol Res2011，2，4： | 1 |
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