|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | Telbivudine:A new treatment for chronic hepatitis B显示文摘世界范围的 3.5 亿个人被估计长期地感染肝炎 B。这些题目的 15%-40% 将在他们的生活期间开发肝硬化,肝失败或肝细胞癌。长期的肝炎 B 的治疗在最后十年优点上戏剧性地改善了到 nucleoside/nucleotide 类似物的来临和 pegylated 干扰素的使用。为长期的肝炎 B 治疗的同意的药包括:标准 interferon-alpha 2b, pegylated interferon-alpha 2a, lamivudine, adefovir dipivoxil,和 entecavir。不幸地,这些代理人不在所有病人是有效的并且与不同副作用被联系。干扰素有众多的副作用和类似物,很好被容忍,需要被用于延长时期的核甙或核苷酸,甚至无止境地。然而,与核甙延长了治疗或核苷酸类似物与抵抗的高率被联系。Telbivudine 是为在长期的肝炎 B 的治疗的使用的新奇、口头上地管理的核甙类似物。与另外的核甙类似物相对照, Telbivudine 没与 mitochondrial 毒性与哺乳动物的 DNA 聚合酶的抑制被联系。Telbivudine 与 lamivudine 相比与反应和优异病毒的抑制的显著地更高的率对肝炎 B 表明了有势力活动,标准疗法。Telbivudine 很好通常被容忍了,与低不利效果侧面,并且在它的有效剂量,没有限制剂量的毒性被观察了。Telbivudine 是之一最有势力为长期的肝炎 B 的抗病毒的代理人并且被食物及药品管理局在 2006 年末同意。 | Deepak N Amarapurkar | 2007 | World Journal of Gastroenterology2007，13，46： | 27 |
| 3 | Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent显示文摘AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-ANCA, c-ANCA, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or culture was positive for AFB. Serological test was not useful in differentiation of CD from GITB. Positivity rates for CD and GITB were:p-ANCA-3.8% and 3.8%, c-ANCA-3.8% and 0%, IgA ASCA-38.4% and 23.1%, and IgG ASCA-38.4% and 42.3%, respectively. CONCLUSION:Simple clinical parameters like fever, bleeding P/R, diarrhoea and duration of symptoms have the highest accuracy in differentiating CD from GITB. | Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane | 2008 | World Journal of Gastroenterology2008，14，5： | 24 |
| 4 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 5 | 腹膜透析和血液透析对尿毒症合并高尿酸血症患者微炎症及痛风发作的影响显示文摘目的研究腹膜透析和血液透析对尿毒症合并高尿酸血症患者微炎症及痛风发作的影响。方法选取湖北医药学院附属随州医院收治的尿毒症合并高尿酸血症患者98例,其中接受血液透析51例(HD组),接受腹膜透析47例(PD组),随访6个月,根据患者是否有痛风性关节炎急性发作分为发作组(A组)和未发作组(NA组),按照其发生次数分为0次、1或2次、3或4次、≥5次4个等级,分别比较HD组与PD组、A组与NA组微炎症因子水平,并比较HD组和PD组患者急性痛风性关节炎急性发作例数的差异。结果PD组体内微炎症因子水平低于HD组患者体内微炎症水平(P<0.05);A组患者体内微炎症因子平均水平较NA组患者高(P<0.05);PD组痛风性关节炎急性发作例数低于HD组(P<0.05)。结论腹膜透析相较血液透析可降低尿毒症合并高尿酸血症患者痛风急性发作的风险,其可能机制为腹膜透析患者体内微炎症水平远低于血液透析患者。 | 邱紫菡 蒋欣辰 Deepak Bhandari 吴屹哲 华杜鹃 高武 黄金平 | 2020 | 中国现代医学杂志2020，30，5： | 19 |
| 6 | 成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。 | Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) | 2007 | 国际脑血管病杂志2007，15，6： | 18 |
| 7 | Imaging evaluation of traumatic thoracolumbar spine injuries: Radiological review显示文摘Spine fractures account for a large portion of musculoskeletal injuries worldwide. A classification of spine fractures is necessary in order to develop a common language for treatment indications and outcomes. Several classification systems have been developed based on injury anatomy or mechanisms of action, but they have demonstrated poor reliability, have yielded little prognostic information, and have not been widely used. For this reason, the Arbeitsgemeinschaftfür Osteosynthesefragen(AO) committee has classified thorocolumbar spine injuries based on the pathomorphological criteria into3 types(A: Compression; B: Distraction; C: Axial torque and rotational deformity). Each of these types is further divided into 3 groups and 3 subgroups reflecting progressive scale of morphological damage and the degree of instability. Because of its highly detailed sub classifications, the AO system has shown limited interobserver variability. It is similar to its predecessors in that it does not incorporate the patient's neurologic status.The need for a reliable, reproducible, clinically relevant, prognostic classification system with an optimal balance of ease of use and detail of injury description contributed to the development of a new classification system, the thoracolumbar injury classification and severity score(TLICS). The TLICS defines injury based on three clinical characteristics: injury morphology, integrity of the posterior ligamentous complex, and neurologic status of the patient. The severity score offers prognostic information and is helpful in decision making about surgical vs nonsurgical management. | Shivanand Gamanagatti Deepak Rathinam Krithika Rangarajan Atin Kumar Kamran Farooque Vijay Sharma | 2015 | World Journal of Radiology2015，7，9： | 18 |
| 8 | 战略决策过程:批判性回顾与未来研究展望显示文摘本文在对以往文献进行回顾的基础上,构建了一个战略决策过程的整合框架。该框架将决策过程特征的前置因素(环境因素、组织因素和决策专有因素)及其过程结果和经济结果整合在一起。依据该框架,本文对重要的实证研究文献进行了综述,指出了主要的研究模式以及研究成果中的矛盾之处。在综述的基础上,文章还探讨了本研究对于理论构建、研究方法和管理实践的启示,并指出了未来研究的一些方向。 | Nandini Rajagopalan Abdul M. A. Rasheed Deepak K. Datta 苗莉(译) | 2012 | 管理世界2012，28，1： | 15 |
| 9 | 髋臼四方区组合钢板治疗髋臼双柱骨折显示文摘目的 探讨髋臼四方区组合钢板治疗髋臼双柱骨折的临床有效性和可靠性。方法 回顾性分析2016年6月至2017年8月采用髋臼四方区组合钢板治疗15例髋臼双柱骨折患者资料,男9例,女6例;年龄26~68岁,平均42.8岁;均为Letournel-Judet分型的髋臼双柱骨折,其中4例合并无后脱位机制后壁骨折。术前均采集患者DICOM格式骨盆CT薄层扫描数据,采用3D打印技术打印患者骨盆模型,充分了解骨折情况及特点,并将健侧半骨盆进行镜像打印,然后在镜像打印半骨盆模型上,模拟髋臼四方区组合钢板安放,钢板塑形备用。手术采用高位髂腹股沟入路,满意复位后依次置入预弯好的弓状缘内侧钢板(主板)、耻坐钢板、髂坐钢板,分别固定前、中、后三柱,其中耻坐钢板、髂坐钢板分别与主板相组合。结果 手术时间100~240 min,平均150 min;术中出血量600~1 500 ml,平均850 ml;手术切口长度9~13 cm,平均11 cm;术中骨折满意复位后,置入预弯钢板,钢板与钢板、钢板与骨面均贴服良好。术后骨折复位按Matta标准评价,15例患者中,优9例,良4例,可2例,优良率86.7%(13/15)。15例患者均获得随访,随访时间6~12个月,平均10个月。末次随访时髋关节功能按Matta改良的Merle d'Aubigne和Postel评分系统评分,为12~18分,平均16.4分,其中优8例,良4例,可2例,差1例,优良率80.0%(12/15)。结论 髋臼四方区组合钢板治疗髋臼双柱骨折,一方面可阻挡四方区内侧移位,另一方面可牢靠固定完全漂浮的后柱及坐骨体;该钢板为多维度框架固定,安全有效,临床疗效满意。 | 陈开放 杨帆 郭晓东 熊泽康 姚升 朱丰照 Drepaul Deepak 孙亭方 姬彦辉 | 2018 | 中华骨科杂志2018，38，5： | 11 |
| 10 | Triple plating of tibia in a complex bicondylar tibial plateau fracture显示文摘高精力的胫骨的高原骨折为整形外科的外科医生提出重要挑战和困难。胫骨的高原的骨折包含主要重量适用连接并且可以改变膝 kinematics。近似胫骨的关节的表面,手足轴(手足排列) 的恢复和允许早联合的运动的稳定的固定的解剖重建是处理的目标。在胫骨的高原折断的复杂 bicondylar 的情况下,孤立侧面的 plating 经常与内翻足 malalignment 被联系,更好的结果通过双切口与双边的 plating 被获得了。然而,有时,胫骨的高原折断的 bicondylar 的一种复杂类型在中间的高原在哪个让 biplaner 象 sagittal 飞机一样在以后的花冠飞机断裂被遇到。在如此的破裂,与在两架飞机支持修理中间的高原是必要的。近似胫骨的一个如此的破裂模式通过双 posteromedial 由三倍的 plating 设法,在前面偏一边的切口在这类损害,外科的途径和管理的机制上与强调在这份情况报告被讨论。 | Atin Jaiswal Naiman Deepak Kachchhap Yashwant S Tanwar Birendra Kumar Sachin K Yadav | 2014 | Chinese Journal of Traumatology2014，17，3： | 10 |
| 11 | Solving the electronic structure problem with machine learning显示文摘Simulations based on solving the Kohn-Sham(KS)equation of density functional theory(DFT)have become a vital component of modern materials and chemical sciences research and development portfolios.Despite its versatility,routine DFT calculations are usually limited to a few hundred atoms due to the computational bottleneck posed by the KS equation.Here we introduce a machine-learning-based scheme to efficiently assimilate the function of the KS equation,and by-pass it to directly,rapidly,and accurately predict the electronic structure of a material or a molecule,given just its atomic configuration.A new rotationally invariant representation is utilized to map the atomic environment around a grid-point to the electron density and local density of states at that grid-point.This mapping is learned using a neural network trained on previously generated reference DFT results at millions of grid-points.The proposed paradigm allows for the high-fidelity emulation of KS DFT,but orders of magnitude faster than the direct solution.Moreover,the machine learning prediction scheme is strictly linear-scaling with system size. | Anand Chandrasekaran Deepak Kamal Rohit Batra Chiho Kim Lihua Chen Rampi Ramprasad | 2019 | npj Computational Materials2019，，1： | 10 |
| 12 | Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-γ显示文摘AIM: To evaluate the in vitro anti-HBV activity of recombinant human IFN-γ, alone and in combination with lamivudine. METHODS: A recombinant baculovirus-HBV/HepG2 culture system was developed which could support productive HBV infection in vitro. Expression of HBsAg and HBeAg in infected HepG2 culture medium was detected by commercial enzyme immunoassays. HBV DNA replication intermediates were detected in infected cells by Southern hybridization and viral DNA load was determined by dot hybridization. RESULTS: IFN-γat 0.1 to 5μg/L efficiently down regulated HBsAg expression in transduced HepG2 cells. At 5μg/L, IFN-γalso suppressed HBV DNA replication in these cells. While treatment with a combination of lamivudine and IFN-γshowed no additive effect, sequential treatment first with lamivudine and then IFN-γwas found to be promising. In this culture system the best HBV suppression was observed with a pulse of 2μmol/L lamivudine for two days, followed by 1μg/L IFN-γfor another four days. Compared to treatment with lamivudine alone, the sequential use of 0.2μmol/L lamivudine for two days, followed by 5μg/L IFN-γfor six days showed a 72% reduction in HBV cccDNA pool. CONCLUSION: This in vitro study warrants further evaluation of a combination of IFN-γand lamivudine, especially in IFN-αnon-responder chronic hepatitis B patients. A reduced duration of lamivudine treatment would also restrict the emergence of drug-resistant HBV mutants. | Mohammad Khalid Parvez Deepak Sehgal Shiv Kumar Sarin Seemi Farhat Basir Shahid Jameel | 2006 | World Journal of Gastroenterology2006，12，19： | 10 |
| 13 | Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity显示文摘在植物免疫,激活病原体的细胞内部的核苷酸绑定 / 白氨酸富人重复(NLR ) 受体动员疾病抵抗小径,但是下游的发信号机制仍然保持阴暗。(EDS1 ) 提高的疾病危险性 1 在 Toll-Interleukin1-Receptor 触发的抵抗控制 transcriptional reprogramming 域(TIR ) 家庭 NLR (TNL ) 。水杨酸酸(SA ) 的 Transcriptional 正式就职荷尔蒙防卫部门对 biotrophic 病原体提供一个关键障碍。这里,我们现在的基因、分子的证据在 Arabidopsis ? 有它的搭挡 PAD4 的 EDS1 建筑群 ? 禁止 MYC2,反对 SA jasmonic 酸(JA ) 的一个主人管理者荷尔蒙小径。在 TNL 有免疫力的反应,有 MYC2 的 EDS1/PAD4 干扰独立于导致 EDS1 的 SA 合成增加 SA 防卫部门,有效地从而堵住一个有势力的行动细菌的 JA 模仿, coronatine (英国管) 。我们证明在英国管在 nucle 剔 ? 畦据楴湯椠 ? 牁 'L 摩灯楳? 晡敦瑣 ? 桴 ? 硥牰獥楳湯漠 ? 内被察觉到以后, MYC2 的那对抗发生 ? 楬業整 ? ?獢瑥漠 ? 敧敮 ? 潣瑮潲汬摥戠 ? 剐至 ? 佐奌佃 ? 删偅 ? 卓噉? 佃偍 ???? 湩汣摵湩 ? 桴 ? 汦睯牥湩 ? 楴敭爠来汵瑡牯吗?? | Haitao Cui Jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao Jaqueline Bautor Jane E. Parker | 2018 | Molecular Plant2018，11，8： | 10 |
| 14 | Neuroendocrine neoplasms of liver-A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification显示文摘AIM To study the clinicopathological characteristics of neuroendocrine neoplasms(NEN) on liver samples and apply World Health Organization(WHO) 2010 grading of gastroenteropancreatic(GEP) NEN.METHODS Clinicopathological features of 79 cases of NEN of the liver diagnosed between January 2011 to December 2015 were analyzed. WHO 2010 classification of GEP NEN was applied and the tumors were graded as G1, G2 or G3. Two more categories, D1/2(discordant 1/2) and D2/3(discordant 2/3) were also applied. The D1/2 grade tumors had a mitotic count of G1 and Ki-67 index of G2. The D2/3 tumors had a mitotic count of G2 and Ki-67 index of G3. The follow up details which were available till the end of the study period(December 2015) were collected.RESULTS Of the 79 tumors, 16 each were G1 and G2, and 18 were G3 tumors. Of the remaining 29 tumors, 13 were assigned to D1/2 and 16 were D2/3 grade. Male preponderance was noted in all tumors except for G2 neoplasms, which showed a slight female predilection. The median age at presentation was 47 years(range 10-82 years). The most common presentation was abdominal pain(81%). Pancreas(49%) was the most common site of primary followed by gastrointestinal tract(24.4%) and lungs(18%). Radiologically, 87% of the patients had multiple liver lesions. Histopathologically, necrosis was seen in only D2/3 and G3 tumors. Microvascular invasion was seen in all grades. Metastasis occurred in all grades of primary NEN and the grades of the metastatic tumors and their corresponding primary tumors were similar in 67% of the cases. Of the 79 patients, 36 had at least one follow up visit with a median duration of follow up of 8.5 mo(range: 1-50 mo). This study did not show any impact of the grade of tumor on the short term clinical outcome of these patients.CONCLUSION Liver biopsy is an important tool for clinicopathological characterization and grading of NEN, especially when the primary is not identified. Eighty-seven percent of the patients had multifocal liver lesions irrespective of the WHO grade, indicating a higher stage of disease at presentation. Follow up duration was inadequate to derive any meaningful conclusion on long term outcome in our study patients. | Deepak Kalyansingh Burad Thomas Alex Kodiatte Sayd Mohamed Rajeeb Ashish Goel Chundamannil Eapen Eapen Banumathi Ramakrishna | 2016 | World Journal of Gastroenterology2016，22，40： | 10 |
| 15 | Evaluation of mine scale longwall top coal caving parameters using continuum analysis显示文摘A mine-scale analysis of Longwall Top Coal Caving (LTCC) is performed using a continuum mechanics finite element solver called COSFLOW. The uniqueness of COSFLOW is that it incorporates Cosserat continuum theory in its formulation for describing the load deformation of bedded rocks. It is shown that such a continuum based code is valuable for assessing the feasibility of introducing LTCC in any mine. Various LTCC parameters, for example chock convergences, top coal failure behavior, strata cavingmechanism, abutment stresses and vertical stresses, were evaluated for a mine using COSFLOW. | Manoj Khanal Deepak Adhikary Rao Balusu | 2011 | Mining Science and Technology2011，21，6： | 9 |
| 16 | Changing spectrum of Budd-Chiari syndrome in India with special reference to non-surgical treatment显示文摘AIM: To evaluate patterns of obstruction, etiological spectrum and non-surgical treatment in patients with Budd-Chiari syndrome in India.METHODS: Forty-nine consecutive cases of Budd-Chiari syndrome (BCS) were prospectively evaluated. All patients with refractory ascites or deteriorating liver function were, depending on morphology of inferior vena cava (IVC) and/or hepatic vein (HV) obstruction, triaged for radiological intervention, in addition to anticoagulation therapy. Asymptomatic patients, patients with diuretic-responsive ascites and stable liver function, and patients unwilling for surgical intervention were treated symptomatically with anticoagulation.RESULTS: Mean duration of symptoms was 41.5 ± 11.2 (range = 1-240) mo. HV thrombosis (HVT) was present in 29 (59.1%), IVC thrombosis in eight (16.3%), membranous obstruction of IVC in two (4%) and both IVC-HV thrombosis in 10 (20.4%) cases. Of 35 cases tested for hypercoagulability, 27 (77.1%) were positive for one or more hypercoagulable states. Radiological intervention was technically successful in 37/38 (97.3%): IVC stenting in seven (18.9%), IVC balloon angioplasty in two (5.4%), combined IVC-HV stenting in two (5.4%), HV stenting in 11 (29.7%), transjugular intrahepatic portosystemic shunt (TIPS) in 13 (35.1%) and combined TIPS-IVC stenting in two (5.4%). Complications encountered in follow-up: death in five, re-stenosis of the stent in five (17.1%), hepatic encephalopathy in two and hepatocellular carcinoma in one patient. Of nine patients treated medically, two showed complete resolution of HVT.CONCLUSION: In our series, HVT was the predominant cause of BCS. In the last five years with the availability of sophisticated tests for hypercoagulability, etiologies weredefined in 85.7% of cases. Non-surgical management was successful in most cases. | Deepak N Amarapurkar Sundeep J Punamiya Nikhil D Patel | 2008 | World Journal of Gastroenterology2008，14，2： | 9 |
| 17 | Interactive Effects of Elevated CO_2 and Growth Temperature on the Tolerance of Photosynthesis to Acute Heat Stress in C_3 and C_4 Species显示文摘Determining effects of elevated CO2 on the tolerance of photosynthesis to acute heat-stress (heat wave) is necessary for predicting plant responses to global warming,as photosynthesis is thermolabile and acute heat-stress and atmospheric CO2 will increase in the future.Few studies have examined this,and past results are variable,which may be due to methodological variation.To address this,we grew two C3 and two C4 species at current or elevated CO2 and three different growth temperatures (GT).We assessed photosynthetic thermotolerance in both unacclimated (basal tolerance) and preheat-stressed (preHS=acclimated) plants.In C3 species,basal thermotolerance of net photosynthesis (Pn) was increased in high CO2,but in C4 species,Pn thermotlerance was decreased by high CO2 (except Zea mays at low GT); CO2 effects in preHS plants were mostly small or absent,though high CO2 was detrimental in one C3 and one C4 species at warmer GT.Though high CO2 generally decreased stomatal conductance,decreases in Pn during heat stress were mostly due to non-stomatal effects.Photosystem Ⅱ (PSⅡ efficiency was often decreased by high CO2 during heat stress,especially at high GT; CO2 effects on post-PSII electron transport were variable.Thus,high CO2 often affected photosynthetic theromotolerance,and the effects varied with photosynthetic pathway,growth temperature,and acclimation state.Most importantly,in heat-stressed plants at normal or warmer growth temperatures,high CO2 may often decrease,or not benefit as expected,tolerance of photosynthesis to acute heat stress.Therefore,interactive effects of elevated CO2 and warmer growth temperatures on acute heat tolerance may contribute to future changes in plant productivity,distribution,and diversity. | E. William Hamilton III Scott A. Heckathorn Puneet Joshi Dan Wang Deepak Barua | 2008 | Journal of Integrative Plant Biology2008，50，11： | 8 |
| 18 | Proximate Composition,Mineral Content and Fatty Acids Analyses of Aromatic and Non-Aromatic Indian Rice显示文摘Awareness on nutritive value and health benefits of rice is of vital importance in order to increase the consumption of rice in daily diet of the human beings. In this study, a total of six aromatic and two non-aromatic rice accessions grown in India were analysed for their nutritional quality attributes including proximate composition, mineral contents and fatty acids. Data with three replications were used to measure Pearson's simple correlation co-efficient in order to establish the relationship among various nutritional quality attributes. The result on proximate composition showed that Govind Bhog had the highest moisture(13.57%) and fat(0.92%) content, which signifies its tasty attribute. Badshah Bhog exhibited the highest fibre content(0.85%), carbohydrate content(82.70%) and food energy(365.23 k Cal per 100 g). Among the minerals, the higher Ca(98.75 mg/kg), Zn(17.00 mg/kg) and Fe(31.50 mg/kg) were in Gopal Bhog, whereas the highest Na(68.85 mg/kg) was in Badshah Bhog, the highest K(500.00 mg/kg) was in Swetganga, Khushboo and Sarbati. The highest contents of unsaturated fatty acids viz. oleic acid(49.14%), linoleic acid(46.99%) and linolenic acid(1.27%) were found in Sarbati, whereas the highest content of saturated fatty acids viz. myristic acid(4.60%) and palmitic acid(31.91%) were found in Govind Bhog and stearic acid(6.47%) in Todal. The identified aromatic rice accessions Gopal Bhog, Govind Bhog and Badshah Bhog and non-aromatic rice accession Sarbati were found nutritionally superior among all eight tested accessions. The nutritional quality oriented attributes in this study were competent with recognized prominent aromatic and non-aromatic rice accessions as an index of their nutritional worth and recommend to farmers and consumers which may be graded as export quality rice with good unique nutritional values in international market. | Deepak Kumar VERMA Prem Prakash SRIVASTAV | 2017 | Rice science2017，24，1： | 8 |
| 19 | Current progress in use of adipose derived stem cells in peripheral nerve regeneration显示文摘Unlike central nervous system neurons; those in the peripheral nervous system have the potential for full regeneration after injury. Following injury, recovery is controlled by schwann cells which replicate and modulate the subsequent immune response. The level of nerve recovery is strongly linked to the severity of the initial injury despite the significant advancements in imaging and surgical techniques. Multiple experimental model shave been used with varying successes to augment the natural regenerative processes which occur following nerve injury. Stem cell therapy in peripheral nerve injury may be an important future intervention to improve the best attainable clinical results. In particular adipose derived stem cells(ADSCs) are multipotent mesenchymal stem cells similar to bone marrow derived stem cells, which are thought to have neurotrophic properties and the ability to differentiate into multiple lineages. They are ubiquitous within adipose tissue; they can form many structures resembling the mature adult peripheral nervous system. Following early in vitro work; multiple small and large animal in vivo models have been used in conjunction with conduits, autografts and allografts to successfully bridge the peripheral nerve gap. Some of the ADSC related neuroprotective and regenerative properties have been elucidated however much work remains before a model can be used successfully in human peripheral nerve injury(PNI). This review aims to provide a detailed overview of progress made in the use of ADSC in PNI, with discussion on the role of a tissue engineered approach for PNI repair. | Shomari DL Zack-Williams Peter E Butler Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 20 | Ischemic colitis masquerading as colonic tumor:Case report with review of literature显示文摘Ischemic colitis can mimic a carcinoma on computed tomographic (CT) imaging or endoscopic examination. A coexisting colonic carcinoma or another potentially obstructing lesion has also been described in 20% of the cases of ischemic colitis. CT scan can differentiate it from colon cancer in 75% of cases. However, colonoscopy is the preferred method for diagnosing ischemic colitis as it allows for direct visualization with tissue sampling. Varied presentations of ischemic colitis have been described as an ulcerated or submucosal mass or as a narrowed segment of colon with ulcerated mucosa on colonoscopy. Awareness and early recognition of such varied presentations of a common condition is necessary to differentiate from a colonic carcinoma, and to avoid unnecessary surgery and related complications. | Parakkal Deepak Radha Devi | 2011 | World Journal of Gastroenterology2011，17，48： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员