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| 1 | Prevalence of occult HBV infection in haemodialysis patients with chronic HCV显示文摘瞄准:与长期的 HCV 在血液透析病人学习流行和秘密 HBV 感染的临床的效果。方法:有否定 HbsAg 的五十个长期的牙齿过敏细胞溶解病人,和积极 anti-HCV 在学习被包括。这些病人被划分成二个组:积极的 HCV-RNA 和 HCV-RNA negative,基于 HCV-RNA PCR 的结果。HBV-DNA 在两个组用 PCR 方法被学习。结果:任何一个都没由 PCR 方法在浆液 22 个 HCV-RNA 积极病人和 28 个 HCV-RNA 否定病人揭示 HBV-DNA。平均年龄是 47.2 +/- 17.0 在 HCV-RNA 积极的组和 39.6 +/- , 15.6 在 HCV-RNA negative 组织。结论:秘密 HBV 感染的流行不在有在我们的区域的长期的 HCV 的血液透析病人高。我们的学习的这结果不得不在我们的区域在在 HBsAg 确实(8%-10%) 和 HBV 异种的频率之间的相互作用的考虑被评估。 | Vedat Goral Hamza Ozkul Selahattin Tekes Dede Sit Ali Kemal Kadiroglu | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 2 | Biliary fistula after treatment for hydatid disease of the liver:When to intervene显示文摘AIM:To determine the outcome of patients with biliary fistula(BF)after treatment for hydatid disease of the liver. METHODS:Between January 2000 and December 2010,out of 301 patients with a diagnosis of hydatid cyst of the liver,282 patients who underwent treatment [either surgery or puncture,aspiration,injection and reaspiration(PAIR)procedure]were analysed.Patients were grouped according to the presence or absence of postoperative biliary fistula(PBF)(PBF vs no-PBF groups,respectively).Preoperative clinical,radiological and laboratory characteristics,operative characteristics including type of surgery,peroperative detection of BF,postoperative drain output,morbidity,mortality and length of hospital stays of patients were compared amongst groups.Multivariate analysis was performed to detect factors predictive of PBF.Receiver operative characteristics(ROC)curve analysis were used to determine ideal cutoff values for those variables found to be significant.A comparison was also made between patients whose fistula closed spontaneously(CS)and those with intervention in order to find predictive fac-tors associated with spontaneous closure. RESULTS:Among 282 patients[median(range)age, 23(16-78)years;77.0%male];210(74.5%)were treated with conservative surgery,33(11.7%)radical surgery and 39(13.8%)underwent percutaneous drainage with PAIR procedure A PBF developed in 46(16.3%) patients,all within 5 d after operation.The maximum cyst diameter and preoperative alkaline phosphatase levels(U/L)were significantly higher in the PBF group than in the no-PBF group[10.5±3.7 U/L vs 8.4±3.5 U/L(P<0.001)and 40.0±235.1 U/Lvs 190.0±167.3 U/L(P=0.02),respectively].Hospitalization time was also significantly longer in the PBF group than in the no-PBF group[37.4±18.0 d vs 22.4±17.9 d(P< 0.001)].A preoperative high alanine aminotransferase level(>40 U/L)and a peroperative attempt for fistula closure were significant predictors of PBF development (P=0.02,95%CI:-0.03-0.5 and P=0.001,95%CI:0.1-0.4),respectively.Comparison of patients whose PBF CS or with biliary intervention(BI)revealed that the mean diameter of the cyst was not significantly different between CS and BI groups however maximum drain output was significantly higher in the BI group(81.6± 118.1 cm vs 423.9±298.4 cm,P<0.001).Time for fistula closure was significantly higher in the BI group(10.1 ±3.7 d vs 30.7±15.1 d,P<0.001).The ROC curve analysis revealed cut-off values of a maximum bilious drainage<102 mL and a waiting period of 5.5 postoperative days for spontaneous closure with the sensitivity and specificity values of(83.3%-91.1%,AUC:0.90)and (97%-91%,AUC:0.95),respectively.The multivariate analysis demonstrated a PBF drainage volume<102 mL to be the only statistically significant predictor of spontaneous closure(P<0.001,95%CI:0.5-1.0). CONCLUSION:Patients with PBF after hydatid surgery often have complicated postoperative course with serious morbidity.Patients who develop PBF with an output <102 mL might be managed expectantly. | Nazif Zeybek Hakan Dede Deniz Balci Ali Kagan Coskun Ismail Hakki Ozerhan Subutay Peker Yusuf Peker | 2013 | World Journal of Gastroenterology2013，19，3： | 5 |
| 3 | Predictors of Cognitive Dysfunction after Major Noncardiac Surgery显示文摘 | Terri G. Monk B Craig Weldon Cyndi W. Garvan Duane E. Dede Maria T. van der Aa Kenneth M. Heilman Joachim S. Gravenstein | 2008 | Anesthesiology2008，，1： | 5 |
| 4 | Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically显示文摘AIM:To examine the effects of ethanol-induced proteasome inhibition,and the effects of proteasome inhibition in the regulation of epigenetic mechanisms. METHODS:Rats were fed ethanol for 1 mo using the Tsukamoto-French model and were compared to rats given the proteasome inhibitor PS-341(Bortezomib, Velcade?)by intraperitoneal injection.Microarray analysis and real time PCR were performed and proteasome activity assays and Western blot analysis were performed using isolated nuclei. RESULTS:Chronic ethanol feeding caused a significant inhibition of the ubiquitin proteasome pathway in the nucleus,which led to changes in the turnover of transcriptional factors,histone-modifying enzymes, and,therefore,affected epigenetic mechanisms. Chronic ethanol feeding was related to an increase in histone acetylation,and it is hypothesized that the proteasome proteolytic activity regulated histone modifications by controlling the stability of histone modifying enzymes,and,therefore,regulated the chromatin structure,allowing easy access to chromatin by RNA polymerase,and,thus,proper gene expression.Proteasome inhibition by PS-341 increased histone acetylation similar to chronic ethanol feeding. In addition,proteasome inhibition caused dramatic changes in hepatic remethylation reactions as there was a significant decrease in the enzymes responsible for the regeneration of S-adenosylmethionine,and, in particular,a significant decrease in the betaine- homocysteine methyltransferase enzyme.This suggested that hypomethylation was associated with proteasome inhibition,as indicated by the decrease in histone methylation. CONCLUSION:The role of proteasome inhibition in regulating epigenetic mechanisms,and its link to liver injury in alcoholic liver disease,is thus a promising approach to study liver injury due to chronic ethanol consumption. | Joan Oliva Jennifer Dedes Samuel W French Fawzia Bardag-Gorce | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 5 | Mathematical, Mathematics Educational, and Educational Values in Mathematical Modeling Tasks显示文摘Purpose:The purpose of this study is to explore the mathematical values,mathematics educational values,and educational values invoIved in mathematical modeling tasks based on different mathematical modeling perspectives.Design/Approach/Methods:In this con text,the prese nt study is a qualitative research based on document analysis.The data were analyzed usingsemantic content analysis,and the selected modeling tasks based on different mathematical modeling perspectives were examined at the sentence level.Findings:Control,mystery,and openness mathematical values appeared in all mathematical modeling tasks,and rationalism and objectivism mathematical values appeared in realistic/applied and socio-critical modeli ng perspectives.Product,exploration,creating,releva nee,pleasure,and application mathematics educational values also emerged in all modeling tasks.Educational values of social justice,equity,social welfare,humanity,and altruism were more important in the socio critical modeling,while the value of individualism was more emphasized in the model-eliciting approach.Originality/Value:By determining mathematical,mathematics educational,and educational values involved in mathematical modeling tasks based on different mathematical modeling perspectives,an effective and more value-balaneed mathematical modeling instruction can be provided. | Yiiksel Dede Veysel Akcakin Gürcan Kaya | 2021 | ECNU Review of Education2021，4，2： | 4 |
| 6 | Non-contact tensile viscoelastic characterization of microscale biological materials显示文摘Many structures and materials in nature and physiology have important 'meso-scale' structures at the micron lengthscale whose tensile responses have proven difficult to characterize mechanically. Although techniques such as atomic force microscopy and micro-and nano-identation are mature for compression and indentation testing at the nano-scale, and standard uniaxial and shear rheometry techniques exist for the macroscale, few techniques are applicable for tensile-testing at the micrometre-scale, leaving a gap in our understanding of hierarchical biomaterials. Here, we present a novel magnetic mechanical testing(MMT) system that enables viscoelastic tensile testing at this critical length scale. The MMT system applies non-contact loading, avoiding gripping and surface interaction effects. We demonstrate application of the MMT system to the first analyses of the pure tensile responses of several native and engineered tissue systems at the mesoscale, showing the broad potential of the system for exploring micro-and meso-scale analysis of structured and hierarchical biological systems. | Yuhui Li Yuan Hong Guang-Kui Xu Shaobao Liu Qiang Shi Deding Tang Hui Yang Guy M.Genin Tian Jian Lu Feng Xu | 2018 | Acta Mechanica Sinica2018，34，3： | 3 |
| 7 | Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy显示文摘Impaired renal function is associated with a high risk of chronicity of hepatitis B virus(HBV) infection.Patients on hemodialysis(HD) or peritoneal dialysis are at an increased risk of viral transmission due to frequent necessity of blood product transfer as well as use of contaminated dialysate or dialysis materials.Additionally,health professionals may cause viral spread via contaminated hands and carelessness against hygiene rules.The frequency of chronic HBV infection may be as high as 80% in patients on renal replacement therapies.This is because HBV vaccination is essential to eliminate chronic HBV infection.However,response rates of HD patients to HBV vaccination vary between 10%-50%.Dialysis adequacy and early vaccination before the onset of dialysis therapy seem to be major determinants of high seroconversion rates.Older age,male gender,duration of dialysis therapy and nutritional status are other well-known factors associated with seroconversion rate.There are controversial reports regarding the role of the presence of diabetes mellitus,HCV positivity,erythropoietin resistance,hyperparathyroidism,and vitamin D inadequacy.The role of genetic alteration in the functions or production of cytokines still needs to be elucidated. | Dede Sit Bennur Esen Ahmet Engin Atay Hasan Kayabasi | 2015 | World Journal of Hepatology2015，7，5： | 3 |
| 8 | Rapid and user-friendly open-source CRISPR/Cas9 system for single-or multi-site editing of tomato genome显示文摘CRISPR/Cas9-induced genome editing is a powerful tool for studying gene function in a variety of organisms,including plants.Using multi-sgRNAs to target one or more genes is helpful to improve the efficacy of gene editing and facilitate multi-gene editing.Here,we describe a CRISPR/Cas9 system which can be conveniently developed as a CRISPR kit.SgRNA expression cassettes can be rapidly generated by one-step PCR using our CRISPR kit.In our kit,there are two binary vectors pHNCas9 and pHNCas9HT.The binary vector pHNCas9 was constructed to allow to assemble up to eight sgRNA expression cassettes by one-step Golden Gate cloning.Another binary vector pHNCas9HT can be used to generate a large number of single target constructs by directly transforming ligation reactions products into A.tumefaciens without several procedures,such as PCR and plasmid extraction.The two binary vectors are designed according to the principles of standard BioBrick assembly to be used as an open-source tool.For example,we used BioBrick as a visual T-DNA tag.We also developed a primer design aid to complement the system.With this primer design aid,researchers can rapidly obtain primers and GC content,and sgRNA sequence of target site.Our CRISPR/Cas9 system can perform single-and multi-site editing and multiple gene editing to produce various types of mutations in tomato.This rapid and user-friendly CRISPR/Cas9 system for tomato can be potentially used for mutagenesis of important crop species for genetic improvement and is suitable for research into the function of genes. | Nan Hu Zhiqiang Xian Ning Li Yudong Liu Wei Huang Fang Yan Deding Su Jingxuan Chen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 2 |
| 9 | COL7A1基因在营养不良性大疱性表皮松解症的突变研究显示文摘目的探讨COL7A1基因在营养不良性大疱性表皮松解症中突变的基因型与临床表型的关系。方法收集14例营养不良性大疱性表皮松解症家系,皮肤活检进行常规组织病理、免疫荧光及电镜检查,采集外周血,提取基因组DNA进行COL7A1基因突变筛查。结果显性遗传型中的3个家系为COL7A1基因错义突变所致,泛发性隐性遗传型中4个家系结合了两个提前终止密码子突变,另外3个结合一个提前终止密码子和剪切位点或甘氨酸错义突变,3个局限性隐性遗传型家系则由提前终止密码子和错义突变引起。结论显性遗传型由甘氨酸错义突变所致,隐性遗传型则包括无义突变、剪切位点突变、插入或缺失突变等。 | 党宁宁 逄曙光 初晶学 Dedee Murrell 李春阳 | 2011 | 山东大学学报(医学版)2011，49，8： | 2 |
| 10 | Dowling-Meara型单纯性大疱性表皮松解症一家系角蛋白基因突变研究显示文摘目的:研究一家族性Dowling Meara型单纯性大疱性表皮松解症(EBS)中的遗传基础,分析患者的基 因突变及确定EBS的亚型。方法:应用外周血提取DNA、PCR扩增、基因序列分析的方法检测患病家族者的K5和 K14的所有外显子区。结果:检测K5基因的所有外显子,未发现突变位点;检测了K14基因的所有外显子,在第一 外显子区发现了R125C的突变。两例患者(母亲和女儿)具有相同的突变,而未患病的父亲及正常对照则无此突 变。结论:该EBS DM家系中存在K14基因R125C的突变,角蛋白基因突变的检测是区分EBS DM患者表型和明 确诊断的有效的方法。 | 赵亚力 韩为东 马学斌 李琦 郝好杰 Dedee Murreu | 2005 | 军医进修学院学报2005，26，1： | 2 |
| 11 | Predictors of Cognitive Dysfunction after Major Noncardiac Surgery显示文摘 | Terri G. Monk B Craig Weldon Cyndi W. Garvan Duane E. Dede Maria T. van der Aa Kenneth M. Heilman Joachim S. Gravenstein | 2008 | Anesthesiology2008，，1： | 2 |
| 12 | 高等教育中的MOOC大数据分析显示文摘高等教育中数据密集型研究和分析所面临的重大挑战,在于探寻适当的方法,从当今正在生成的、极其丰富的数据集中提取出知识,并提炼成为对学生、教师和公众有用的信息。技术和方法的进步使人们获得了前所未有的基于大数据的决策能力。大数据已经在商业、娱乐、科学、技术和工程领域中充分确立了这一用途。高等教育尽管也在决策领域中利用了大数据,但在教学的实际应用中仍然非常稀有。 | Chris Dede Andrew Ho Piotr Mitros 陈强 | 2016 | 中国教育网络2016，，12： | 2 |
| 13 | SlGRAS4 accelerates fruit ripening by regulating ethylene biosynthesis genes and SlMADS1 in tomato显示文摘GRAS proteins are plant-specific transcription factors that play crucial roles in plant development and stress responses.However,their involvement in the ripening of economically important fruits and their transcriptional regulatory mechanisms remain largely unclear.Here,we demonstrated that SlGRAS4,encoding a transcription factor of the GRAS family,was induced by the tomato ripening process and regulated by ethylene.Overexpression of SlGRAS4 accelerated fruit ripening,increased the total carotenoid content and increased PSY1 expression in SlGRAS4-OE fruit compared to wild-type fruit.The expression levels of key ethylene biosynthesis genes(SlACS2,SlACS4,SlACO1,and SlACO3)and crucial ripening regulators(RIN and NOR)were increased in SlGRAS4-OE fruit.The negative regulator of tomato fruit ripening,SlMADS1,was repressed in OE fruit.Exogenous ethylene and 1-MCP treatment revealed that more endogenous ethylene was derived in SlGRAS4-OE fruit.More obvious phenotypes were observed in OE seedlings after ACC treatment.Yeast one-hybrid and dual-luciferase assays confirmed that SlGRAS4 can directly bind SlACO1 and SlACO3 promoters to activate their transcription,and SlGRAS4 can also directly repress SlMADS1 expression.Our study identified that SlGRAS4 acts as a new regulator of fruit ripening by regulating ethylene biosynthesis genes in a direct manner.This provides new knowledge of GRAS transcription factors involved in regulating fruit ripening. | Yudong Liu Yuan Shi Deding Su Wang Lu Zhengguo Li | 2021 | Horticulture Research2021，8，1： | 2 |
| 14 | Why Design-Based Research is Important and Difficult 显示文摘 | Chri Dede | 2005 | Educational Technology2005，，12： | 1 |
| 15 | Identification of potent,se-lective non-peptide CC chemokine receptor-3antagonist that inhibits eotaxin-,eotaxin-2-,and monocyte chemotactic protein-4-induced eosinophil migration显示文摘 | White JR Lee JM Dede K | 2000 | J Biol Chem2000，275，36： | 1 |
| 16 | Glomerulonephritis association parvovirus B 19 infection 显示文摘 | Onguru P Dede F Bodur H | 2006 | Renal Failure2006，28，： | 1 |
| 17 | Predictors of cognitive dysfunction after major noncardiac surgery 显示文摘 | Monk TG Weldon BC Garvan CW Dede DE van der Aa MT Heilman KM | 2008 | Anesthesiology2008，108，： | 1 |
| 18 | Hormone replacement therapy in postmenopausal women with benign fibrocystic mastopathy显示文摘 | Yenen MC Dede M Goktolga U | 2003 | Climacteric2003，6，2： | 1 |
| 19 | Towards a Roadmap for Future Home Networking Systems: An Analytical Hierarchy Process Approach显示文摘 | Dede G Kamalakis T Varoutas D | 2011 | IEEE Systems Journal2011，5，3： | 1 |
| 20 | Global cardiovascular risk associated with hypertension and extent of treatment and control according to risk group显示文摘 | Wong ND Dede J Chow VH | 2012 | Am J Hypertens2012，25，5： | 1 |
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