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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of heat-moisture treatment on rice starch of varying amylose content显示文摘 | Elessandra da Rosa Zavareze Cátia Regina Storck Luis Antonio Suita de Castro Manoel Artigas Schirmer Alvaro Renato Guerra Dias | 2009 | Food Chemistry2009，，2： | 1 |
| 3 | A new mesophase of isotactic polypropylene in copolymers of propylene with long branched comonomers 显示文摘 | De Rosa C Auriemma F Di Girolamo R | 2010 | Macromolecules2010，43，20： | 1 |
| 4 | 查看详情显示文摘 | De Rosa C Auriemma F Di Capua A Resconi L. Guidotti S. Camurati I. Nifant'ev I.E.and Laishevtsev I.P | | 0，，： | 1 |
| 5 | A key role of leptin in the control of regulatory T cell proliferation显示文摘 | De Rosa V Procaccini C Cali G | 2007 | Immunity2007，26，2： | 1 |
| 6 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 7 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 8 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 9 | A key role of leptin in the control of regulatory T cell proliferation显示文摘 | De Rosa V Procaecini C Call G | 2007 | Immunity2007，26，2： | 1 |
| 10 | Diffusion-weigh- ted imaging findings in Perthes disease with dynamic gadolini- um-enhanced subtracted (DGS) MR correlation: a preliminary study 显示文摘 | Merlini L Combescure C De Rosa V | 2010 | Pediatr Radiol2010，40，3： | 1 |
| 11 | Thymosin cd continues to show promise as an enhancer for vaccine response 显示文摘 | Tuthill C Rios I De Rosa A | 2012 | Ann N Y Acad Sci2012，1270，1： | 1 |
| 12 | Strict glycaernic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial 显示文摘 | De La Rosa Gdel C Donado 1H Restrepo AH | 2008 | Crit Care2008，12，5： | 1 |
| 13 | Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed显示文摘 | Silva-Sa'nchez C de la Rosa A P León-Galván M F | 2008 | J Agric Food Chem2008，56，4： | 1 |
| 14 | At the crossroad of T cells,adipose tissue,and diabetes显示文摘 | Matarese G Procaccini C De Rosa V | 2012 | Immunol Rev2012，249，1： | 1 |
| 15 | Allosteric properties of hemoglobin and the plasma membrane of the erythrocyte : New in- sights in gas transport and metabolic modulation 显示文摘 | De Rosa MC Carelli Alinovi C Galtieri A | 2008 | IUBMB Life2008，60，2： | 1 |
| 16 | Family Psycho-educational Interventions for Schizophrenia in Routine Setting:Impact of Patients' Clinical Status and Social Functioning and on relatives' Burden and Resources显示文摘 | Magliano L Fiorillo A Magliano C De Rosa C Favata G Sasso A Prezioso M | | 0，，03： | 1 |
| 17 | Trehalose production:exploiting novel approaches显示文摘 | Schiraldi C Di Lernia I De Rosa M | 2002 | Trends Biotechnol2002，20，10： | 1 |
| 18 | The Interactive Effects of Proactive Personality and Work family Interference on Well-being 显示文摘 | CUNNINGHAM C J L DE LA ROSA G M | 2008 | Journal of Occupational Health Psychology2008，13，3： | 1 |
| 19 | An application of the independent component analysis to monitor acoustic emission signals generated by termite activity in wood 显示文摘 | Gonzalez de la Rosa J J Puntonet C G Lloret I | 2005 | Measurement2005，37，1： | 1 |
| 20 | A key role of leptin in the control of regulatory T cell proliferation 显示文摘 | De Rosa V Procaccini C Call G | 2007 | Immunity2007，26，2： | 1 |
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