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| 1 | Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: Randomized placebo-controlled trial显示文摘AIM: To estimate if and to what extent long acting octreotide (LAR) improves survival and quality of life in patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 127 cirrhotics, stages A-B, due to chronic viral infections and with advanced HCC, were enrolled in the study. Scintigraphy with 111Indium labeled octreotide was performed in all cases. The patients with increased accumulation of radionuclear compound were randomized to receive either oral placebo only or octreotide/octreotide LAR only as follows: octreotide 0.5mg s.c. every 8 h for 6 wk, at the end of wk 4-8 octreotide LAR 20 mg i.m. and at the end of wk 12 and every 4 wk octreotide LAR 30mg i.m.. Follow-up was worked out monthly as well as the estimation of quality of life (QLQ-C30 questionnaire). Patients with negative somatostatin receptors (SSTR) detection were followed up in the same manner. RESULTS: Scintigraphy demonstrated SSTR in 61 patients. Thirty were randomized to receive only placebo and 31 only octreotide. A significantly higher survival time was observed for the octreotide group (49 ± 6 wk) as compared to the control group (28 ± 1 wk) and to the SSTR negative group (28 ± 2 wk), LR = 20.39, df = 2, P < 0.01. The octreotide group presented 68.5% lower hazard ratio [95% CI (47.4%-81.2%)]. During the f irst year, a 22%, 39% and 43% decrease in the QLQ-C30 score was observed in each group respectively.CONCLUSION: The proposed therapeutic approach has shown to improve the survival and quality of life in SSTR positive patients with advanced HCC. | D Dimitroulopoulos D Xinopoulos K Tsamakidis A Zisimopoulos E Andriotis D Panagiotakos A Fotopoulou C Chrysohoou A Bazinis D Daskalopoulou E Paraskevas | 2007 | World Journal of Gastroenterology2007，13，23： | 18 |
| 2 | Stroke : epidemiology, clinical picture, and risk factors-Part Ⅰ of Ⅲ 显示文摘 | Tegos TJ Kalodiki E Daskalopoulou SS | 2000 | Angiology2000，51，10： | 1 |
| 3 | E6/E7 mRNA ex-pression of high-risk HPV types in 849 Greek women 显示文摘 | Argyri E Tsimplaki E Daskalopoulou D | 2013 | Anti-cancer Res2013，33，9： | 1 |
| 4 | Five cases ofpleural mesothelioma with endemic pleural calcifications in a l′u-ral area in Greece显示文摘 | Sichletidis L Daskalopoulou E Tsarou V | 1992 | Med Lav1992，83，4： | 1 |
| 5 | Stroke:epidemiology,clinical picture,and risk factors-Part I of III 显示文摘 | Tegos T J Kalodiki E Daskalopoulou S S | 2000 | Angiology2000，51，10： | 1 |
| 6 | Stroke:Epidemiology,clinical picture,and risk factors Part I of III显示文摘 | Tegos TJ Kalodiki E Daskalopoulou SS | 2000 | Angiology2000，51，10： | 1 |
| 7 | Stroke:pathogenesis,investigations,and prognosis Part Ⅱ of Ⅲ显示文摘 | Tegos TJ Kalodiki E Daskalopoulou SS | 2000 | Angiology2000，51，11： | 1 |
| 8 | Long-term treatment of deep venous thrombosis with a low molecular weight hep- arin (tinzaparin) :a prospective randomized trial显示文摘 | Daskalopoulos ME Daskalopoulou SS Tzortzis E | 2005 | Eur J Vasc En- :lovasc Surg2005，29，6： | 1 |
| 9 | Stroke:epidemiology, clinical picture, and risk factors-Part I of III显示文摘 | Tegos TJ Kalodiki E Daskalopoulou SS | 2000 | Angiology2000，51，： | 1 |
| 10 | E6/E7 mRNA ex- pression of high - risk HPV types in 849 Greek women 显示文摘 | Argyri E Tsimplaki E Daskalopoulou D | 2013 | Antican- cer Research2013，33，9： | 1 |
| 11 | See ondery prevention of isehemic vascular disease~ what is the evi denee显示文摘 | Paraskeras K I Daskalopoulou S S Daskalopouls M E | 2005 | Angiology2005，56，5： | 1 |
| 12 | Evaluation of five different questionnaires for assessing sleep apnea syndrome in a sleep clinic显示文摘 | PATAKA A DASKALOPOULOU E KALAMA-RAS G | 2014 | Sleep Med2014，15，： | 1 |
| 13 | Evaluation of five different questionnaires for assessing sleep apnea syndrome in a sleep clinic显示文摘 | Pataka A Daskalopoulou E Kalamaras G | 2014 | Sleep Med2014，15，7： | 1 |
| 14 | Sexual delusion in a case of vaginal aplasia after surgical operation for neovagina显示文摘 | MELLIOU H DASKALOPOULOU E I'2VDOKIMIDES I | 2012 | Clin gxp Obslet Gynecol2012，39，2： | 1 |
| 15 | Evalua tion of five different questionnaires for assessing sleep ap- nea syndrome in a sleep clinic显示文摘 | Pataka A Daskalopoulou E Kalamaras G | 2014 | Sleep Med2014，15，7： | 1 |
| 16 | Early statin therapy in patients with acute coronary syndrome显示文摘 | LIBEROPOULOS E N DASKALOPOULOU S S MIKHAILIDIS D P | | 0，，01： | 1 |
| 17 | Long-term treatment of deep venous thrombosis with a low molecular weight heparin (tinzaparin): a prospective randomized trial 显示文摘 | Daskalopoulos ME Daskalopoulou SS Tzortzis E | 2005 | Eur J Vase Endovase Surg2005，29，6： | 1 |
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