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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Noneatalytic aleoholysis kinetics of soybean oil显示文摘 | Dasari M A Golf M J Suppes G J | 2003 | Journal of the American Oil Chemists'' Society2003，80，2： | 1 |
| 3 | Low-pressure hydrogenolysis of glycerol to propylene glycol 显示文摘 | Dasari M A Kiatsimkul P P Sutterlin W R | 2005 | Appl Catal A Gen2005，281，12： | 1 |
| 4 | Susceptibility to scratch surface damage of wollastonite and talc containing polypropylene micrometric composites 显示文摘 | Hadal R Dasari A Rohrmann J | 2004 | Materials Science and Engineering A2004，380，12： | 1 |
| 5 | Micro- and nano- scale deformation behavior of nylon 66- based binary and ternary nanocomposites 显示文摘 | Dasari A Yu Z Z Yang M | 2006 | Composites Science and Technology2006，66，16： | 1 |
| 6 | Phase-dispersion optical tomography显示文摘 | YANG C WAX A DASARI R R | 2001 | Opt Lett2001，26，10： | 1 |
| 7 | Phase I pharmacokinetic andpharmacodynamic study of cetuximab, irinotecan and sorafenib inadvanced colorectal cancer显示文摘 | Azad N Dasari A Arcaroli J | 2013 | Invest New Drugs2013，31，： | 1 |
| 8 | Roles of graphite oxide,clay and POSS during the combustion of polyamide 6显示文摘 | Dasari A Yu Z Z Mai Y W | 2009 | Polymer2009，50，6： | 1 |
| 9 | Clay exfoliation and organic modification on wear of nylon 6 nanocomposites processed by different routes显示文摘 | DASARI A YU Z Z MAI Y W | 2005 | Compes Sci Technol2005，65，1516： | 1 |
| 10 | Transesterification of soybean oil with zeolite and metal catalysts 显示文摘 | Suppes G J Dasari M A Doskocil E J | 2004 | Appl Catal A : Gen2004，257，： | 1 |
| 11 | Low pressure hydrogenolysis of glycerol to propylene glycol 显示文摘 | DASARI M A KIATSIMKUL P P SUTTERLIN W R | 2005 | Applied Catalysis A: General2005，281，12： | 1 |
| 12 | Fracture toughness of nylon 6/ organoclay/elastomer nanocomposites 显示文摘 | Lim S H Dasari A Yu Z Z | 2007 | Composites Science and Technology2007，67，14： | 1 |
| 13 | Transesterification of soybean oil with zeolite and metal catalysts显示文摘 | SUPPES G J DASARI M A DOSKOCIL E J | 2004 | Applied Catalysis A:Genera2004，257，2： | 1 |
| 14 | On Toughness and Stiffness ofPoly(butyleneterephthalate)with Epoxide-Containing Elasto-mer by Reactive Extrusion显示文摘 | Yu Z Z Yan C Dasari A | 2004 | Macromolecular Materials andEngineering2004，289，： | 1 |
| 15 | Low-pressure hydrogenolysis of glycerol to propylene glycol 显示文摘 | Dasari M A Kiatsimkula P P Sutterlin W R | 2005 | Appl Catal A2005，281，12： | 1 |
| 16 | Noncatalytic alcoholysis kinetics of soybean oil显示文摘 | Dasari M A Goff M J Suppes G J | 2003 | Journal of the American oil chemists'' society2003，80，3： | 1 |
| 17 | Low-pressure hydrogenolysis of glycerol to propylene glycerol显示文摘 | Dasari M A Kiatsimkul P-P Sutterlin W R | 2005 | Appl Catal A:General2005，281，12： | 1 |
| 18 | Chinese ink-facilitated fabrication of carbon nanotube/polyvinyl alcohol composite sheets with a high nanotubeloading显示文摘 | Yah W L Dasari A Kong L B | 2014 | Composites: PartA2014，61，： | 1 |
| 19 | Surface characteristics and wear performance of laser surface engineered iron oxide coatings on cast aluminum alloy显示文摘 | DASARI A NAYAK S MISRA R D K | 2002 | Materials Science and Technology2002，18，9： | 1 |
| 20 | Low-pressure hydrogenolysis of glycerol to propylene glycerol显示文摘 | DASARI M A KIATSIMKUL Pim-Pahn SUTTERLIN W R | 2005 | Applied Catalysis A2005，281，： | 1 |
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