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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development显示文摘The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed germination.Here we describe the Dof-like gene family in grapevine(Vitis vinifera L.),which consists of 25 genes coding for Dof.An extensive in silico characterization of the VviDofL gene family was performed.Additionally,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)analyses.The phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated genes.The diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological roles.Furthermore,distinct expression patterns were identified between samples analyzed,corroborating such hypothesis.Our expression results indicate that several VviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and production.The identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir. | Danielle Costenaro da Silva Vítor da Silveira Falavigna Marianna Fasoli Vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers | 2016 | Horticulture Research2016，3，1： | 5 |
| 3 | Diagnosis of placental abruption: relationship between clinical and histopathological findings 显示文摘 | Elsasser DA Ananth CV Prasad V | 2010 | Eur J Obstet Gynecol Reprod Biol2010，148，2： | 1 |
| 4 | Charaterization of immobilized laccase from Lentinuls edodes and use in olive-mill waste water treatment 显示文摘 | Alessandro DA Silvia RS Vittorio V | 1999 | Process Biochem1999，34，6： | 1 |
| 5 | Inhibition of Rho-kinase by fasudil attenuated angiotensin Ⅱ-induced cardiac hypertrophy in apolipoprotein E deficient mice显示文摘 | Wang YX da Cunba V Martin-McNulty B | 2005 | Eur J Pharmacol2005，512，23： | 1 |
| 6 | Pancreatic agenesis attibuable to a single nucleotide deletion in the human IPF1 gene coding sequence 显示文摘 | Stoffers DA Zinkin NT Stanojevic V | 1997 | Nat Genet1997，15，1： | 1 |
| 7 | Application of chronological load modeling in composite reliability worth evaluation显示文摘 | Mello J C O Pereira M V F Leite da Silva A M | 1997 | Electric Power Systems Research1997，，40： | 1 |
| 8 | Safty of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke显示文摘 | Battistella V de Freitas GR da Fonseca LM | 2011 | Regen Med2011，6，1： | 1 |
| 9 | Human CD4+ CD25+ regulatory T cells显示文摘 | Baecher-Allan C Viglietta V Hafler DA | 2004 | Semin Immunol2004，16，： | 1 |
| 10 | Computational fluid dynamics design and analysis of a passively suspended Tesla pump left ventricular assist device显示文摘 | Medvitz RB Boger DA Izraelev V | | 0，，05： | 1 |
| 11 | Detoxification of lignocellulose hydrolysates:biochemical and metabolic engineering toward white biotechnology显示文摘 | CHANDEL A K DA SILVA S S SINGH O V | | 0，，1： | 1 |
| 12 | C-reactive pro- tein level measurement improves mortality prediction when added to the spontaneous intracerebral hemorrhage score显示文摘 | Di Napoli M Godoy DA Campi V | 2011 | Stroke2011，42，5： | 1 |
| 13 | Diagnosis of placental abruption:relationship between clinical and histopathological findings显示文摘 | Elsasser DA Ananth CV Prasad V | 2010 | Eur J Obstet Gynecol Reprod Biol2010，148，： | 1 |
| 14 | Diel Variation of Larval Fish Abundance in the Amazon and Rio Negro显示文摘 | ARAUJO-LIMA C A DA SILVA V V PETRY P | 2001 | Brazilian Journal of Biology2001，61，3： | 1 |
| 15 | Inhibition of human CD2 CD+25 high regulatory T cell function 显示文摘 | Viglietta V Hafler DA | 2002 | J Immunol2002，169，11： | 1 |
| 16 | Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice 显示文摘 | da Cunha V Fitch R | 2000 | Am J Physiol Heart Circ Physiol2000，278，5： | 1 |
| 17 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 18 | The effects of low laser irradiation on angiogenesis in injured rat tibiae显示文摘 | Garavello I Baranauskas V Da cruz-hofling MA | 2004 | Histol Histopathol2004，19，： | 1 |
| 19 | The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo显示文摘 | Cowley S Ko M Pick N Chow R Downing KJ Gordhan BG Betts JC Mizrahi V Smith DA Stokes RW Av-Gay Y | 2004 | Mol Microbiol2004，52，6： | 1 |
| 20 | Differential gene up-regulation by hypoxia-inducible factor-1 αlpha and hypoxia-inducible factor-2alpha in HEK293T cells显示文摘 | Wang V Davis DA Haque M | 2005 | Cancer Res2005，65，： | 1 |
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