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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | 术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文)显示文摘Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. | Kim HJ Park YS Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS | 2012 | 中华神经外科疾病研究杂志2012，11，4： | 13 |
| 3 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 4 | Chelex-100 as a medium for simple extraction of DNA for PCR-based typing from forensic material显示文摘 | Walsh PS Metzger DA Higuchi R | 1991 | Biotechniques1991，10，4： | 2 |
| 5 | Anti-estrogen stimulate human endometrial cancer growth:laboratory and clinical consideration显示文摘 | Tonetti DA O Regan R Tanjore S | 1998 | J Steroid Biochem Mol Biol1998，65，： | 1 |
| 6 | Comparative study of propylene polymerization using Me2Si(Rind)2ZrCl2/SiO2-SMAO/AlR3 and Me2Si(RInd)2ZrCl2/MAO(R=Me, H)显示文摘 | Franceschini F C da R Tavares T T dos Santos J H Z | 2007 | Polymer2007，48，7： | 1 |
| 7 | Intermittent high glucose enhances ICAM-1,VCAM-1,E-selectin and interleukin-6 expression in human umbilical endothelial Cells in culture: the role of poly(ADPribose)polymerase显示文摘 | Piconi L Quagliaro L Da Ros R | 2004 | J Thromb Haemost2004，2，： | 1 |
| 8 | Long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease显示文摘 | Casaburi R Mahier DA Jones PW | 2002 | Eur Respir2002，19，： | 1 |
| 9 | Impairment of endotheliumdependent dilation response after resuscitation from hemorrhagic shock involved postreceptor mechanisms显示文摘 | Garrison RN Spain DA | 2004 | Shock2004，21，2： | 1 |
| 10 | Liver fibrosis显示文摘 | Brenner DA | 2005 | J Clin Invest2005，115，4： | 1 |
| 11 | Effects of race and family history of type 2 diabetes on metabolie status of women withpolycystie ovary syndrome显示文摘 | Ehrmann DA Kasza K Azziz R | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 12 | Can the neuropathic Pain Scale discriminate between non-neuropathic and neuropathic pain 显示文摘 | Fishbain DA Lewis JE Cutler R | 2008 | Pain Medicine2008，9，2： | 1 |
| 13 | Determination of triglycer- ides in human plasma using near-infrared spectroscopy and multivariate calibration methods 显示文摘 | da Costa Filho P A Poppi R J | 2001 | Analytica Chimica Acta2001，446，12： | 1 |
| 14 | Physiological responses to salt stress in young umbu plants显示文摘 | Da Silva E C Nogueira R J M C de Arajo F P etal | 2008 | Environmental and Experimental Botany2008，63，3： | 1 |
| 15 | Mechanisms mediating renal sympathetic activation to leptin in obesity显示文摘 | Morgan DA Thedens DR Weiss R | 2008 | Am J Physiol Regul Integr CompPhysiol2008，295，6： | 1 |
| 16 | α-resolution principle on lattice-valued propositional logic LP(X) 显示文摘 | Xu Y Da R Kerre E E | 2000 | Information Sciences2000，130，： | 1 |
| 17 | Cutting edge : negative selection of immature thymocytes by a few pepfide MHC complexes: differential sensitivity of immature and mature T cells显示文摘 | Peterson DA Dipaolo R J Kanagawa O | 1999 | J lmmunol1999，162，6： | 1 |
| 18 | Functional difference of the PDS gene product are associated c phenotypic variation in patients c pendred syndrome & non-syndromic hearing loss (DFNB4) 显示文摘 | Scott DA Wang R Kreman TM | 2000 | Hum Mol Genet2000，9，11： | 1 |
| 19 | Application of thermostable xylanases from Humicola sp for pulp improvement显示文摘 | Da Silva R Yim D K Park Y K | 1994 | J Ferment Bioeng1994，77，1： | 1 |
| 20 | An enzyme-linked immunosorbent assay for the detection of vesicular stomatitis virus antibodies 显示文摘 | Allende R Sepulveda L Mendes da Silva A | 1992 | Prev Vet Med1992，14，： | 1 |
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