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| 1 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 2 | Autochthonous hepa- titis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood do- nors, the elderly and patients with chronic liver disease显示文摘 | Dalton H R Stableforth W Thurairajah P | 2008 | Eur J Gastroenterol Hepatol2008，20，8： | 1 |
| 3 | Hepatitis E: an emer-ging infection in developed countries 显示文摘 | Dalton H R Bendall R Ijaz S | 2008 | Lancet Infect Dis2008，，8： | 1 |
| 4 | Extracorporeal Life Support Registry Report2004显示文摘 | Conrad SA Rycus PT Dalton H | 2005 | ASAIO J2005，51，： | 1 |
| 5 | Initial public offering investor valuations: an examination of top management team prestige and environmental uncertainty 显示文摘 | Lester R H Certo S T Dalton C M Dalton D R Cannella A A | 2006 | Journal of Small Business Management2006，44，1： | 1 |
| 6 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 7 | Properties of Portland cement made from contaminated sediments 显示文摘 | Jennifer L Dalton Kevin H Gardner | 2004 | Conservation and Recycling2004，41，3： | 1 |
| 8 | Continuous dielectrophoretic cell seperation microfluidic device 显示文摘 | Li Y Dalton C Crabtree H J | 2007 | Lab Chip2007，7，： | 1 |
| 9 | Regulation of gene expression by reactive oxygen显示文摘 | Dalton T P Shertzer H G and Puga A | 1999 | Annu Rev Pharmacol Toxicol1999，39，： | 1 |
| 10 | Hepatitis E: an emerging infection in developed countries 显示文摘 | Dalton H R Bendall R Ijaz S | 2008 | Lancet Infect Dis2008，8，11： | 1 |
| 11 | Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure 显示文摘 | Dalton V K Saunders N A Harris L H | 2006 | Feail Steril2006，85，6： | 1 |
| 12 | Effects of sound types and volumes on simulated driving, vigilance tasks and heart rate显示文摘 | DALTON B H BEHM D G KIBELe A | 2007 | Occupational Ergonomics2007，7，3： | 1 |
| 13 | Acetylene as a suicide substrate and active site probe for methane monooxygenase from Methylococcus capsulatus(Bath)显示文摘 | Prior S D Dalton H | 1985 | FEMS Microbiology Letter1985，29，： | 1 |
| 14 | Aggressive pa- pillary glioneuronal tumor: case report and literature review 显示文摘 | Newton H B Dalton J Ray-Chaudhury A | 2008 | Clin Neuropathol2008，27，5： | 1 |
| 15 | A Com- parison of Two Commercially Available Anti-HEV IgG Kits and a Re-Evaluation of Anti-HEY IgG Sero- prevalence Data in Developed Countries显示文摘 | Bendall R Ellis V Ijaz S All R Dalton H | 2010 | Journal of Medical Virology2010，82，5： | 1 |
| 16 | Multicentre comparison of the Glasgow Blatchford and Rockall Scores in the prediction of clinical end-points after upper gastrointestinal haemorrhage显示文摘 | Stanley A J Dalton H R Blatchford O | 2011 | Aliment Pharmacol Ther2011，34，4： | 1 |
| 17 | Are R&D Organizations Obsolete?显示文摘 | DALTON G W | 1976 | Harvard Business Review1976，54，11： | 1 |
| 18 | Vortex induced vibrations usinglarge Eddy Simulation at a moderate Reynolds number显示文摘 | Al-Jamal H Dalton C | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 19 | The effect of propofol on the canine sphincter of Oddi显示文摘 | Baron T H Dalton C B Cotton P B | 1994 | HPB Surg1994，7，29： | 1 |
| 20 | Intrauter-ine adhesions after manual vacuum aspiration for early pregnancy failure显示文摘 | DALTON V K SAUNDERS N A HARRIS L H | 2006 | Fertil Steril2006，85，6： | 1 |
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