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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021,5,4: | 3 |
| 2 | Effect of different culture mediaand light intensities on growth of Haematococcus pluvialis显示文摘 | Imamoglu E SukanE Dalay M C | 2007 | International Journal of Natural and Engineering Sciences2007,1,2: | 1 |
| 3 | Coverage of scalp defects fol- lowing contact electrical bums to the head : a clinical series 显示文摘 | Dalay C Kesiktas E Yavuz M | 2006 | Bums2006,32,2: | 1 |
| 4 | Organic matter and microbial biomass in a Vertisol after 20 years of zero--tillage显示文摘 | Dalai R C Henderson P A Guasby J M | 1991 | Soil Biology and Biochemistry1991,23,: | 1 |
| 5 | Coverage of scalp defects following contact lectrical burns to the head: a clinical series 显示文摘 | Dalay C Kesiktas E Yavuz M | 2006 | Bums2006,32,2: | 1 |
| 6 | Knowledge flows though informal con- tacts in industrial clusters: myth or realities? 显示文摘 | Dalai M Pedersen C | 2004 | Research Policy2004,33,10: | 1 |
| 7 | Coverage of scalp defects following contact electrical burns to the head:a clinical series显示文摘 | Dalay C Kesiktas E Yavuz M | 2006 | Burns2006,32,2: | 1 |
| 8 | Semi-continuous cultivation of Haematococcus pluvialis for commercial production 显示文摘 | IMAMOGLU E DALAY M C SUKAN F V | 2010 | Appl Biochem Bio- technol2010,160,3: | 1 |
| 9 | Antibacterial activity of volatile component and various extracts of Spirul- ina platensis 显示文摘 | Ozdemir G Karabay N U Dalay M C | 2004 | Phytother Res2004,18,9: | 1 |
| 10 | Interaction between iron, manganese and the Al-Si eutectic in hypoeutectic A1-Si alloys 显示文摘 | Dirmis C M Taylor J A Dalai A K | 2006 | Metallurgical and Materials Tranactions2006,37,11: | 1 |
| 11 | Incidence and predictors of venous thromboembolism ( VTE ) among ambulatory patients with lung cancer显示文摘 | Connolly G C Dalai M Lin J | 2012 | Lung Cancer2012,78,: | 1 |
| 12 | Regional differences in ricehulls supply for bioethanol production 显示文摘 | lmamoglu E Dalay M C Sukan F V | 2013 | Applied Biochemistry and Biotechnology2013,171,: | 1 |
| 13 | Metallic prosthesis: technique to avoid increase in CT radiation dose with automatic tube current modulation in a phantom and patients显示文摘 | Dalai T Kalra M K Rizzo S M Schmidt B Suess C Flohr T | 2005 | Radiology2005,236,: | 1 |
| 14 | Composite tempororetroauricular flap for the reconstruction of the lower lid and eye socket in the elderly显示文摘 | DALAY A C YAVUZ O M KIVANC K | 1996 | Eur J Plast Surg1996,19,2: | 1 |
| 15 | Transesterification of karanja (Pongamia pinnata) oil by solid basic catalysts显示文摘 | Meher L C Kulkani M G Dalai A K | 2006 | Eur J Lipid Sci Technol2006,108,5: | 1 |
| 16 | Severity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claims 显示文摘 | Mapel D W Dalai A A Blanchette C M | 2011 | Int JChron Obstruct Pulmon Dis2011,6,: | 1 |
| 17 | Cobalt-catalyzed homocoupling of terminal alkynes: Synthesis of 1,3- diynes 显示文摘 | Krafft M E Hirosawa C Dalai N | 2001 | Tetrahedron Lett2001,42,: | 1 |
| 18 | Organic matter and microbial biomass in a vertisol after 20 years of zero tillage显示文摘 | Dalai R C Henderson P A Glasby J M | 1991 | Soil Boil Biochem1991,23,5: | 1 |
| 19 | Organic matter and microbial biomass in a vertisol after 20 years of zerotillage 显示文摘 | Dalai R C Henderson P A Glasby J M | 1991 | Soil Biol Biochem1991,23,5: | 1 |
| 20 | Organic matter and microbial biomass in a vertisol after 20yr of zero tillage 显示文摘 | Dalai R C Henderson P A Glasby J M | 1991 | Soil Biol Biochem1991,23,: | 1 |