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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | Polyoxometalates:fascinating structures,unique magnetic properties显示文摘 | Kortza U Muller A Slagerenc J.V Schnack J Dalai N.S Dressel M | | 0，，： | 1 |
| 3 | Natural convection in a rectangular cavity heatedfrom below and uniformly cooled from the top and both sides显示文摘 | Dalai A Das M K | 2006 | Numer Heat Transfer Part A2006，49，： | 1 |
| 4 | Effect of different culture mediaand light intensities on growth of Haematococcus pluvialis显示文摘 | Imamoglu E SukanE Dalay M C | 2007 | International Journal of Natural and Engineering Sciences2007，1，2： | 1 |
| 5 | Normal plasma levels of orexin A (hypocretin-l) in narcoleptic patients显示文摘 | Dalai MA Schuld A Haack M | 2001 | Neurology2001，56，： | 1 |
| 6 | Estriol ameliorate sauto immune demyelinating disease implication formultiple sclerosis 显示文摘 | Kim S Liva S M Dalai MA et ai | 1999 | Neurology1999，52，： | 1 |
| 7 | Catalytic conversion of glycerol to value added liquid products显示文摘 | PATHAK K REDDY K M DALAI A K | 2010 | Applied Catalysis A:General2010，372，2： | 1 |
| 8 | The DISCOVER co- dec:architecture, techniques and evaluation 显示文摘 | ARTIGAS X ASCENSO J DALAI M | 2007 | Picture Coding Symposium2007，17，9： | 1 |
| 9 | Increased expression of visfa- tin in macrophages of human unstable carotid and coronary atherosclerosis possible role in inflammation and plaque destabilization 显示文摘 | Dalai riB Yndestad A Skjelland M | 2007 | Circculatoon2007，115，8： | 1 |
| 10 | The AETG System: an Approach to Testing Based on Combinatorial Design 显示文摘 | Cohen D M Dalai S R Fredman M L | 1997 | IEEE Transaction on Software Engineering1997，23，7： | 1 |
| 11 | C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease 显示文摘 | Dalai M Vestbo J Lange P | 2007 | Am J Respir Crit Care Med2007，175，3： | 1 |
| 12 | Genetic alterations of the WWOX gene in breast cancer显示文摘 | Ekizoglu S Muslumanoglu M Dalay N | 2012 | Med Oncol2012，29，3： | 1 |
| 13 | Changes in the lumbar fora- men following anterior interbody fusion with tapered or cylindrical cages显示文摘 | Wang M Dalai S Bagaria V B | 2007 | Spine2007，7，5： | 1 |
| 14 | Increased ex- pression of visfatin in macrophages of human unstable ca-rotid and coronary atherosclerosis: possible role in inflam- mation and plaque destabilization 显示文摘 | Dalai TB Yndestad A Skjelland M | 2007 | Circulation2007，115，8： | 1 |
| 15 | The AETG System:an approach to testing based on combinatorial design 显示文摘 | COHEN D M DALAI S R FREDMAN M L | 1997 | IEEE Trans on Software Engineering1997，23，7： | 1 |
| 16 | Estriol ameliorates autoimmune demyelihating disease: Implications for multiple sclerosis injury显示文摘 | Kim S Liva S Dalai M | 1999 | Neurology1999，52，6： | 1 |
| 17 | Synthesis and characterization of vegetable oil derived esters: Evaluation for their diesel additive properties显示文摘 | DMYTRYSHYN S L DALAI A K CHAUDHARI S T MISHRA H K REANEY M J | 2004 | Bioresour Technol2004，92，1： | 1 |
| 18 | The combinatorial design approach to automatic test generation 显示文摘 | COHEN D M DALAI S R PARELIUS J | 1996 | IEEE Software1996，13，5： | 1 |
| 19 | Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease显示文摘 | Thomsen M Dalai M Lange P | 2012 | Am J Res- pir Crit Care Med2012，186，10： | 1 |
| 20 | Neurological manifestations of Hansen's disease and their management显示文摘 | Agrawal A Pandit L Dalai M | 2005 | Clin Neurol Neurosurg2005，107，： | 1 |
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