|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Breast cancer resistance protein(BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression显示文摘Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily G member 2(ABCG2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer cells.BCRP physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis barriers.BCRP recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical use.Thus,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer drugs.Because BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor prognosis.Therefore,blocking BCRP-mediated active efflux may provide a therapeutic benefit for cancers.Delineating the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated MDR.Current evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated receptor.Furthermore,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer cells.Finally,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of conditions.These biological events seem involved in a complicated manner.Untangling the events would be an essential first step to developing a method to modulate BCRP function to aid patients with cancer.This review will present a synopsis of the impact of BCRP-mediated MDR in cancer cells,and the molecular mechanisms of acquired MDR currently postulated in a variety of human cancers. | Takeo Nakanishi Douglas D.Ross | 2012 | Chinese Journal of Cancer2012，31，2： | 32 |
| 2 | BCRP基因在非小细胞肺癌组织和非癌肺组织中的表达及意义显示文摘目的:进一步研究从人类乳腺癌细胞株 (MCF-7/AdrVp)中克隆出的、对蒽环类抗癌药耐药的 BCRP基因在非癌肺组织及非小细胞肺癌组织中的表达。方法:从术后即刻获得的正常肺组织和有活力的非小细胞肺癌组织新鲜标本中及时提取细胞总 RNA,通过 RT-PCR及 PCR法获得并扩增 BCRP基因的 cDNA产物,再经凝胶电泳分离 BCRP基因 cDNA带,然后再通过转膜技术把这些 BCRP基因 cDNA产物转移到杂交膜上,用 Southern blot杂交技术检测 BCRP基因的表达程度。结果:细胞总 RNA分别从 8个只有肺癌组织标本和 12对同时获取的肺癌组织及非癌肺组织标本中成功提取,然后用变性凝胶电泳鉴定提取 RNA的质量。其中 4例标本因术中缺血时间太长,或有坏死炎症或术前放化疗等原因,所提 RNA有降解而放弃进一步的检测。通过 RT-PCR及 PCR方法从 16例可用标本中获得并扩增 BCRP基因的 cDNA产物,再通过转膜及 Southern blot杂交技术,最终发现 BCRP基因在正常肺组织中均有不同程度的表达( 10/10),而在非小细胞肺癌组织标本中只有一半病人的标本有不同程度的表达 (8/16)。结论: BCRP基因可能是一个在非癌肺组织中常规表达的基因,而在部分病人的肺癌组织中可能此基因有缺失或被抑制。因此。 | 毛友生 Austin Doyle Weidong Yang Yuetong Wei Mark J.Krasna Douglas D.Ross | 2001 | 癌症2001，20，3： | 9 |
| 3 | Predicting and monitoring cancer treatment response with diffusion‐weighted MRI显示文摘 | Harriet C.Thoeny Brian D.Ross | 2010 | J Magn Reson Imaging2010，，1： | 3 |
| 4 | DUAL URBAN AND RURAL HYDROGRAPH SIGNALS IN THREE SMALL WATERSHEDS显示文摘 | Scott A.Sheeder Jeremy D.Ross Toby N.Carlson | 2007 | JAWRA Journal of the American Water Resources Association2007，，4： | 1 |
| 5 | Predicting and monitoring cancer treatment response with diffusion‐weighted MRI显示文摘 | Harriet C.Thoeny Brian D.Ross | 2010 | J. Magn. Reson. Imaging2010，，： | 1 |
| 6 | 电影艺术和科学学院的新型扬声器系统显示文摘 | J.Eargle J.Bonner D.Ross | | 0，，06： | 1 |
| 7 | 叔胺及其衍生物市场显示文摘 | JohnColling D.Ross | 2002 | 日用化学工业信息2002，，11： | 1 |
| 8 | Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia显示文摘X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads tohypophosphatemia and impaired mineralization of bone and teeth. The clinical manifestations of XLH include a high prevalence ofdental abscesses and periodontal disease, likely driven by poorly formed structures of the dentoalveolar complex, including thealveolar bone, cementum, dentin, and periodontal ligament. Our previous studies have demonstrated that sclerostin antibody (SclAb) treatment improves phosphate homeostasis, and increases long bone mass, strength, and mineralization in the Hyp mousemodel of XLH. In the current study, we investigated whether Scl-Ab impacts the dentoalveolar structures of Hyp mice. Male andfemale wild-type and Hyp littermates were injected with 25 mg·kg−1 of vehicle or Scl-Ab twice weekly beginning at 12 weeks of ageand euthanized at 20 weeks of age. Scl-Ab increased alveolar bone mass in both male and female mice and alveolar tissue mineraldensity in the male mice. The positive effects of Scl-Ab were consistent with an increase in the fraction of active(nonphosphorylated) β-catenin, dentin matrix protein 1 (DMP1) and osteopontin stained alveolar osteocytes. Scl-Ab had no effecton the mass and mineralization of dentin, enamel, acellular or cellular cementum. There was a nonsignificant trend towardincreased periodontal ligament (PDL) attachment fraction within the Hyp mice. Additional PDL fiber structural parameters were notaffected by Scl-Ab. The current study demonstrates that Scl-Ab can improve alveolar bone in adult Hyp mice. | Kelsey A.Carpenter Delia O.Alkhatib Bryan A.Dulion Elizabeth Guirado Shreya Patel Yinghua Chen Anne George Ryan D.Ross | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 9 | Damage Curves Derived from Hurricane Ike in the West of Galveston Bay Based on Insurance Claims and Hydrodynamic Simulations显示文摘Hurricane Ike,which struck the United States in September 2008,was the ninth most expensive hurricane in terms of damages.It caused nearly USD 30 billion in damage after making landfall on the Bolivar Peninsula,Texas.We used the Delft3dFM/SWAN hydrodynamic and spectral wave model to simulate the storm surge inundation around Galveston Bay during Hurricane Ike.Damage curves were established through the relationship between eight hydrodynamic parameters(water depth,flow velocity,unit discharge,flow momentum flux,significant wave height,wave energy flux,total water depth(flow depth plus wave height),and total(flow plus wave)force)simulated by the model and National Flood Insurance Program(NFIP)insurance damage data.The NFIP insurance database contains a large amount of building damage data,building stories,and elevation,as well as other information from the Ike event.We found that the damage curves are sensitive to the model grid resolution,building elevation,and the number of stories.We also found that the resulting damage functions are steeper than those developed for residential structures in many other locations. | Chaoran Xu Benjamin T.Nelson-Mercer Jeremy D.Bricker Meri Davlasheridze Ashley D.Ross Jianjun Jia | 2023 | International Journal of Disaster Risk Science2023，14，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员