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| 1 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 2 | Bank predication:an investigation of cash flow based models 显示文摘 | Aziz Emanuel A D Lawson G | 1998 | Journal of Management Studies1998，，25： | 1 |
| 3 | Compositional modeling with an equation of state 显示文摘 | Nghiem L X Fong D K Aziz K | 1981 | Society of Petroleum Engineering Journal1981，21，12： | 1 |
| 4 | Change in effective stress associated with coal shrinkage and gas sorption显示文摘 | SERESHKI F BRUGGMANN D AZIZ N I | 2005 | Journal of the Mine Ventilation Society of South Africa2005，58，1： | 1 |
| 5 | Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus显示文摘 | Aziz TZ Giladi N | 2002 | Brain2002，125，： | 1 |
| 6 | Bank prediction:an investigation of cash flow based models显示文摘 | EMANUEL D LAWSON G | 1988 | Journal of Management Studies1988，，25： | 1 |
| 7 | Ovarian torsion in children:is oophorectomy necessary?显示文摘 | Aziz D Davis V Allen L | 2004 | J Pediatr Surg2004，39，5： | 1 |
| 8 | Comparative effectiveness of the C-MAC video laryngoscope versus direct laryngoscopy in the setting of the predicted difficult airway显示文摘 | Aziz MF Dillman D Fu R | 2012 | Anesthesiology2012，116，3： | 1 |
| 9 | The management of malignant pleural mesothelioma:single centre experience in 10 years显示文摘 | Aziz T Jilaihawi A Prakash D | 2002 | Eur J Cardiothorac Surg2002，22，2： | 1 |
| 10 | Perinatally diagnosed asymptomatic congenital cystic adenomatoid malformation: to resect or not?显示文摘 | Aziz D Langer JC Tuuha SE | 2004 | J Pediatr Surg2004，39，3： | 1 |
| 11 | Fundamentals of neurogastroenterology: basic science 显示文摘 | Grundy D Chaer ED Aziz Q | 2006 | Gastroenterol2006，130，5： | 1 |
| 12 | HRCT diagnosis of diffuseparenchymal lung disease: inter-observer variation显示文摘 | Aziz Z A Wells A U Hansell D M | 2004 | Thorax2004，59，6： | 1 |
| 13 | Confocal microscopy through a fiber-optic imaging bundle 显示文摘 | GMITRO A F AZIZ D | 1993 | Opt Lett1993，18，8： | 1 |
| 14 | Stimulation of bovine sperm mitochondrial activity by homeopathic dilutions of monensin 显示文摘 | Aziz D M Erdoergs H | 2005 | Homeopathy2005，94，4： | 1 |
| 15 | Routine clinical practice effectiveness of the Glidescope in difficult airway management:an analysis of 2,004 Glidescope intubations,complications,and failures from two institutions显示文摘 | Aziz MF Healy D Kheterpal S | 2011 | Anesthesiology2011，114，1： | 1 |
| 16 | Antigen-specific Th9 cells exhibit u- niqueness in their kinetics of cytokine production and short retention at the inflammatory site显示文摘 | Tan C Aziz M K Lovaas J D | 2010 | J Immunol2010，185，11： | 1 |
| 17 | Degradation mechanism of small molecule-based organic light-emitting devices 显示文摘 | Aziz H Popovic Z D Hu N X | 1999 | Science1999，283，5409： | 1 |
| 18 | Reliability and degradation of small molecule-based organic light-emitting devices (OLEDs)显示文摘 | Popovic Z D Aziz H | 2002 | IEEE Journal on Selected Topics in Quantum Electronics2002，8，2： | 1 |
| 19 | Bank prediction:an investigation of cash flow based models显示文摘 | Aziz A D Emanuel G Lawson | 1988 | Journal of ManagementStudies1988，25，5： | 1 |
| 20 | Acute dissection of the thoracic aorta 显示文摘 | Aziz S Ramsdale D R | 2004 | Hosp Med2004，65，3： | 1 |
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