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| 1 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 2 | The N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GT- Pase Rab2-dependent recruitment to membranes 显示文摘 | Daubenberger C A Tisdale E J Curcic M | 2003 | Biol Chem2003，384，： | 1 |
| 3 | Allocation of Losses in Distribution Systems with Embedded Generation显示文摘 | Mutale J Strbac G Curcic S | 2000 | IEE Proc-Gener Transm & Distrib2000，147，1： | 1 |
| 4 | Total removal of cranlopharyngiomas approaches and long-term resule in 144 patients显示文摘 | sYasargi MG Curcic M Kis M | 1990 | J Neurosurg1990，，： | 1 |
| 5 | Total removal of craniopharyngiomas approaches and long-term results in 144 patients 显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosury1990，73，1： | 1 |
| 6 | Total removal of craniopharyngiomas 显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 7 | Total removal of craniopharyngioma显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurg1990，73，1： | 1 |
| 8 | Polarization selective magnetic vortex dynamics and core reversal in rotating magnetic fields 显示文摘 | Curcic M Van Waeyenberge B V Vansteenkiste A | 2008 | Physical Review Letters2008，101，19： | 1 |
| 9 | Total removal of craniopharyngioma, Approach and long term results in 144 patients 显示文摘 | Yasargil MC Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 10 | Allocation of losses in distribution systems with embedded generation 显示文摘 | Mutale J Strbae G Curcic S | 2000 | IEE Proceedings - Genera- tion Transmission and Distribution2000，147，1： | 1 |
| 11 | Total removal of craniopharyngiomas 显示文摘 | Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 12 | Total removal of craniopharyngiomas:Approaches and long-term results in 144 patients显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 13 | Total removal of craniopharyngiomas: approaches and long-term results in 144 patients 显示文摘 | Yasargil MG Curcic M Kis M | 1990 | Neurosurgery1990，73，： | 1 |
| 14 | Total removal of craniopharyngiomas:Approaches and logn-term results in 144 pations显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurgery1990，73，： | 1 |
| 15 | Gastroesophageal junction:structure and function as assessed by using MR imaging显示文摘 | Curcic J Fox M Kaufman E | | Radiology0，，： | 1 |
| 16 | Total removal of craniopharyngiomas approaches and long-term results in 144 patients显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 17 | Total removal of craniopharyngioma: approches and long-term results in 144 patients 显示文摘 | Yasargil MG Curcic M Kis M | 1990 | J Neurosurg1990，73，： | 1 |
| 18 | Allocation of losses in distribution systems with Embedded Generation显示文摘 | MUTALE J STRBAC G CURCIC S | 2000 | IEE Proceedings-Generation Transmission Distribution2000，147，1： | 1 |
| 19 | The N′-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes显示文摘 | Daubenberger CA Tisdale EJ Curcic M | 2003 | Biol Chem2003，384，： | 1 |
| 20 | Allocation of Losses in Distribution Systems with Embedded Generation显示文摘 | Strbac G Curcic S | 2000 | IEE Proc on Gener Transm&Distrib2000，147，1： | 1 |
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