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| 1 | Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization显示文摘临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那 probiotic。这里,我们在过敏促进感受性上分析了三选择乳杆菌紧张的 immunomodulatory 性质和他们的混合的影响赌 1 用一只 gnotobiotic 老鼠建模的 v。我们显示出那乳杆菌(L.) rhamnosus LOCK0900, L。rhamnosus LOCK0908 和 L。casei LOCK0919 经由像使用费的受体被认出 2 (TLR2 ) 并且核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产 cytokines 的导出髓的树枝状的房间。殖民无菌(GF ) 有所有三紧张(Lmix ) 的混合物的鼠标由加强 enterocytes 的顶端的 junctional 建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与 Lmix 开拓殖民地于并且敏化 1 变应原到赌注 v 的老鼠显著地象一个增加的转变生长因素(TGF ) 一样在 sera 和肠的 lavages 显示出变应原特定的 IgE, IgG1 和 IgG2a 和提高的全部的 IgA 水平的底层 -β与敏化的 GF 老鼠相比铺平。从开拓殖民地于 Lmix 的老鼠的 Splenocytes 和 mesenteric 淋巴节点房间显示出 TGF-β 的重要 upregulation;在以后在有赌注 v 的 vitro 刺激 1。我们的结果证明 Lmix 殖民改进了内脏对赌注 v 的上皮的障碍和减少的过敏促进感受性 1。而且,这些调查结果被传播和能分泌的 IgA 和规章的 cytokine TGF-β 的增加的生产伴随;。因此,三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。 | Hana Kozakova Martin Schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 2 | Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease显示文摘Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development. | Bozena Cukrowska Agnieszka Sowińska Joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk | 2017 | World Journal of Gastroenterology2017，23，42： | 7 |
| 3 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environs显示文摘 | Naicker K Cukrowska E McCarthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 4 | Application of supported liquid membrane probe for extraction and preconcentration of organotin compounds from environmental water samples显示文摘 | Ewa Cukrowska Luke Chimuka | 2004 | Analytica Chimica Acta2004，523，1： | 1 |
| 5 | Acid mine drainage arising from gold mining activity in Johannesburg, South Africa and envi- rons 显示文摘 | Naicker K Cukrowska E McCarthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 6 | Application of Supported Liquid Membrane Probe for Extraction and Preeoncentration of Organotin Com- pounds from Environmental Water Samples显示文摘 | CUKROWSKA E CHIMUKA L NSENGIMANA H | 2004 | Ana- lytica Chemica Acta2004，523，1： | 1 |
| 7 | Ion mobility based on column leaching of South African gold tailings dam with chemo metric evaluation显示文摘 | Cukrowska EM Govender K Viljoen M | 2004 | Chemosphere2004，56，1： | 1 |
| 8 | The impact of post gold mining on mercury pollution in the West Rand region,Gauteng,South Africa显示文摘 | Lusilao-Makiese J G Cukrowska E M Tessier E | 2013 | Journal of Geochemical Exploration2013，134，： | 1 |
| 9 | Specific antibody and immunoglobulin responses after intestinal colonization of germ-free piglets with non-pathogenic Escherichia coli O86 显示文摘 | CUKROWSKA B KOZAKOVA H REHAKOVA Z | 2001 | Immunobiology2001，204，4： | 1 |
| 10 | Development of pressurised hot water extrac tion(PHWE)for essential compounds from Moringa oleiferaleaf extracts显示文摘 | MATSHEDISO PG CUKROWSKAE CHIMUKA L | 2015 | Food Chemistry2015，，172： | 1 |
| 11 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environments显示文摘 | Naicker K Cukrowska E Mc Carthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 12 | Application of supported liquid membrane probe for extraction and preconcentration of organotin compounds from environmental water samples显示文摘 | CUKROWSKA E CHIMUKA L NSENGIMANA H | 2004 | Analytica Chimica Acta2004，523，1： | 1 |
| 13 | Application of supported liquid membrane probe for extraction and preconcentration of organotin compounds from environmental water samples显示文摘 | CUKROWSKAE CHIMUKA L NSENGIMANA H | 2004 | An- alytica Chimica Acta2004，523，1： | 1 |
| 14 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environs显示文摘 | Naicker K Cukrowska E Mc Carthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 15 | Multiwalledcarbon nanotubes as adsorbents for the removal ofparts per billion levels of hexavalent chromium from aqueoussolution 显示文摘 | PILLAY K CUKROWSKA E M COVILLE N | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 16 | Molecular imprinted polymer for solid-phase extraction of flavonolaglycones from Moringa oleifera extracts显示文摘 | PAKADE V CUKROWSKA E LINDAHL S | 2013 | J Sep Sci2013，36，3： | 1 |
| 17 | Specific antibody and immunoglobulin responses after intestinal colonization of germ-free piglets with non-pathogenic Escherichia coli O86显示文摘 | CUKROWSKA B KOZAKOVA H REHAKOVA Z | | 0，，04： | 1 |
| 18 | Extraction and preconcentration of Cr(VI) from urine using supported liquid membrane 显示文摘 | Soko L Cukrowska E Chimuka L | 2002 | Analytica Chimica Acta2002，474，： | 1 |
| 19 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environs显示文摘 | Naicker N Cukrowska E Mccarthy T S | 2003 | Environmental Pollution2003，122，： | 1 |
| 20 | Development ofpressurized hot water extraction (PHWE )for essential compounds fromMoringa oleifera leaf extracts显示文摘 | MATSHEDISO P G CUKROWSKA E CHIMUKA L | 2015 | Food Chemistry2015，172，： | 1 |
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