|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neu tralizing monoclonal antibody to the E1 glycoprotein epitope of rubella virus mediates virus arrest in VERO cells显示文摘 | Cordoba P Grutadauria S Cuffini C Zapata M | 2000 | Viral Immunol2000，13，1： | 1 |
| 2 | Effect of rufloxacin upon non-specific immune defence:in-vitro, ex-vivo and invivo results显示文摘 | Cuffini AM Tullio V kllocco k | 1994 | J Antimicrob Chemother1994，34，4： | 1 |
| 3 | Negative pressure pulmonary oedema after septoplasty 显示文摘 | Garcfa de Hombre AM Cuffini A Bonadeo A | 2013 | Acta Otorrinolaringol Esp2013，64，4： | 1 |
| 4 | Effect of rufloxacin upon non-specific immune defence:in-vitro,ex-vitro and in vivo results显示文摘 | Tullio V Alloco A | 1994 | J Antimicrob Chemother1994，34，4： | 1 |
| 5 | Susceptibility of Prostate Epithelial Cells to Chlamydia muridarum Infection and Their Role in Innate Immunity by Recruitment of Intracellular Toll-Like Receptors 4 and 2 and MyD88 to the Inclusion 显示文摘 | Mackern-Oberti JP Maccioni M Cuffini C | 2006 | Infect Immun2006，74，12： | 1 |
| 6 | Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients 显示文摘 | Motrich RD Cuffini C Mackem Oberti JP | 2006 | J Infect2006，53，3： | 1 |
| 7 | Effect of rufloxacinupon non-specificimmune defences: in-vitro, ex-vivo and in-vivo results显示文摘 | Cuffini AM Tullio V Allocco A | 1994 | J Antimicrob C hemother1994，34，： | 1 |
| 8 | Effect of ruf|oxacin upon non-specific immune defence~ in- vitro, e~vivo, and in-vivo results显示文摘 | Cuffini A M Tullio V Allocco A | 1994 | Jantimicrob Chemother1994，34，54： | 1 |
| 9 | Neutralizing monoclonal antibody to the E1 glycoprotein epitope of rubella virus mediates virus arrest in Vero cells显示文摘 | Corboba P Grutadauria S Cuffini C | 2000 | Viral Immunol2000，13，1： | 1 |
| 10 | Effect of ru- floxacin upon non-specific immune defence: in-vitro, ex-vivo,and in-vivo results显示文摘 | Cuffini A M Tullio V Allocco A | 1994 | J Antimicrob Che- mother1994，34，4： | 1 |
| 11 | Effect of rufloxacin upon non-specific immune defence: in-vitro, ex-vivo and invivo results显示文摘 | Cuffini AM Tullio V AUocco A | 1994 | Journal of Antimicrobial Chemotherapy1994，34，4： | 1 |
| 12 | Cell-fusion assay for the detection of rubella virus in Vero cells 显示文摘 | Grutadauria S Cordoba P Cuffini C | 1998 | Clin Diagn Virol1998，10，1： | 1 |
| 13 | Effect of rufloxacin upon non-specific immune defence:in-vitro,ex-vivo and in-vivo results显示文摘 | Tullio V Allocco A | 1994 | Journal of antimicrobial chemotherapy1994，34，4： | 1 |
| 14 | Susceptibility of prostate epithelial cells to Chlamydia muridarum infection and their role in innate immunity by recruitment of intracellular Toll-like receptors 4 and 2 and MyD88 to the inclusion显示文摘 | Mackern-Oberti JP Maccioni M Cuffini C | 2006 | Infect Immun2006，74，12： | 1 |
| 15 | Immunomodulating effect of antimicrobial agents on cytokine production by human polymorphonuclear neutrophils显示文摘 | Reato G Cuffini AM Tullio V | | 0，，02： | 1 |
| 16 | Irbesartan desmotropes:Solid-state characterization,thermodynamic study and dissolution properties显示文摘Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is a polymorphic system and its forms A and B are related monotropically. These reports indicate form B as the most stable and less soluble form. Therefore, the goal of this contribution is to demonstrate through a complete solid-state characterization, thermodynamic study and dissolution properties that the IBS forms are desmotropes that are not related monotropically. However, the intention is also to call attention to the importance of conducting strict chemical and in solid-state quality controls on the IBS raw materials. Hence, powder X-ray diffraction (PXRD) and Raman spectroscopy (RS) at ambient and non-ambient conditions, differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) techniques were applied. Furthermore, intrinsic dissolution rate (IDR) and structural stability studies at 98% relative humidity (RH), 25℃ and 40 ℃ were conducted as well. The results show that in fact, form A is approximately four-fold more soluble than form B. In addition, both IBS forms are stable at ambient conditions. Nevertheless, structural and/or chemical instability was observed in form B at 40℃ and 98% RH. IBS has been confirmed as a desmotropic system rather than a polymorphic one. Consequently, forms A and B are not related monotropically. | Andrea Mariela Araya-Sibaja Carlos Eduardo Maduro de Campos Cinira Fandaruff Jose Roberto Vega-Baudrit Teodolito Guillen-Giron Mirtha Navarro-Hoyos Silvia Lucía Cuffini | 2019 | Journal of Pharmaceutical Analysis2019，9，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员