| 1 | 补充重组人黄体生成素对于大龄生育期女性降调节后卵巢刺激和种植率的影响显示文摘Objective: To evaluate the effects of recombinant human luteinizing hormone (rhLH) supplementation on ovarian stimulation and implantation rate in down- regulated women of advanced reproductive age. Design: Prospective randomized study.Setting: University teaching hospital.Patient(s): A total of 120 consecutive normogona-dotropic infertile women < 35 years old undergoing their first cycle of IVF or intracytoplasmic sperm injection (ICSI) treatment.Intervention(s): Ovarian stimulation in a long agonist protocol with a combination of recombinant human follicle- stimulating hormone (rhFSH) and rhLH (group 1, n = 60) starting on day 6 of FSH stimulation until hCG at a daily fixed dose of 150 IU of rhLH, or with rhFSH alone (group 2, n = 60).Main Outcome Measure(s): Ovarian stimulation characteristics, ovum retrieval, and IVF/ICSI outcome.Result(s): The mean number of intermediate (10- 14 mm) and large ( > 14- < 18 mm) but not leading ( < 18 mm) follicles was significantly lower in group 1 on the day of hCG injection.The oocyte yield and maturity as well as the number of oocytes fertilized were significantly higher in group 2 than in group 1.However, the number of patients having embryo transfer (n = 55 in both treatment groups), the number and quality of embryos replaced, the implantation rate (20.6% vs.21.7% ) and clinical pregnancy rates per embryo transfer (44% vs.45% ) were similar in groups 1 and 2.Conclusion(s): The rhLH supplementation does not increase ovarian response and implantation rates in patients of older reproductive age stimulated with rhFSH under pituitary suppression for assisted reproductive technologies(ARTs). | Fáabregues F. Creus M. Pearrubia J. J. Balasch 朱亮 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 3 |
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