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| 1 | Role of endoscopic retrograde cholangiopancreatography inthe management of benign biliary strictures:What's new?显示文摘Benign biliary strictures comprise a heterogeneous group of diseases. The most common strictures amenable to endoscopic treatment are post-cholecystectomy, post-liver transplantation, related to primary sclerosing cholangitis and to chronic pancreatitis. Endoscopic treatment of benign biliary strictures is widely used as first line therapy, since it is effective, safe, noninvasive and repeatable. Endoscopic techniques currently used are dilation, multiple plastic stents insertion and fully covered self-expandable metal stents. The main indication for dilation alone is primary sclerosing cholangitis related strictures. In the vast majority of the remaining cases, temporary placement of multiple plastic stents with/without dilation is considered the treatment of choice. Although this approach is effective, it requires multiple endoscopic sessions due to the short duration of stent patency. Fully covered self-expandable metal stents appear as a good alternative to plastic stents, since they have an increased radial diameter, longer stent patency, easier insertion technique and similar efficacy. Recent advances in endoscopic technique and various devices have allowed successful treatment in most cases. The development of novel endoscopic techniques and devices is still ongoing. | Rosa Ferreira Rui Loureiro Nuno Nunes António Alberto Santos Rui Maio Marília Cravo Maria AntóniaDuarte | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 6 |
| 2 | Sedation in gastrointestinal endoscopy: Where are we at in 2014?显示文摘Gastrointestinal endoscopies are invasive and unpleasant procedures that are increasingly being used worldwide. The importance of high quality procedures(especially in colorectal cancer screening), the increasing patient awareness and the expectation of painless examination, increase the need for procedural sedation. The best single sedation agent for endoscopy is propofol which, due to its' pharmacokinetic/dynamic profile allows for a higher patient satisfaction and procedural quality and lower induction and recovery times, while ma-intaining the safety of traditional sedation. Propofol is an anesthetic agent when used in higher doses than those needed for endoscopy. Because of this important feature it may lead to cardiovascular and respiratory depression and, ultimately, to cardiac arrest and death. Fueled by this argument, concern over the safety of its administration by personnel without general anesthesia training has arisen. Propofol usage seems to be increasing but it's still underused. It is a safe alternative for simple endoscopic procedures in low risk patients even if administered by non-anesthesiologists. Evidence on propofol safety in complex procedures and high risk patients is less robust and in these cases, the presence of an anesthetist should be considered. We review the existing evidence on the topic and evaluate the regional differences on sedation practices. | Alexandre Oliveira Ferreira Marília Cravo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，2： | 5 |
| 3 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 4 | Bioaccumulation of metals in the soft tissue of Patella aspera: application of metal/shell weight indices 显示文摘 | Cravo A Bebianno M J | 2005 | Estuarine Coastal and Shelf Science2005，65，3： | 1 |
| 5 | Treatment of gastric MALT lymphoma by helicobacter pylori eradication: a study controlled by endoscopic ultrasonography显示文摘 | Lage P Cravo M | 1998 | Am J Gastroenterol1998，93，5： | 1 |
| 6 | Role of the me- dulla oblongata in hypertension显示文摘 | COLOMBARI E SATO M A CRAVO S L | 2001 | Hypertension2001，38，32： | 1 |
| 7 | Hyperhomocystinemia in Chronic Alcoholism: Correlation with Folate, Vitamin B - 12, and Vitamin B - 6 Status显示文摘 | Gloria L M Selhub J | 1996 | Am J Clin Nutr1996，63，： | 1 |
| 8 | The Muir-Torre syndrome:a rare variant of hereditary nonpolyposis colorectal cancer associated with hMSH2 mutation 显示文摘 | Suspiro A Fidalgo P Cravo M | 1998 | Am J Gastroenterol1998，93，9： | 1 |
| 9 | Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis显示文摘BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms.Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown.AIM To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery.METHODS We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for diagnosis.We evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular analysis.We also assessed publication bias,heterogeneity,and study quality.RESULTS Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the meta-analysis.Genetic testing and microforceps biopsies were identical for diagnosis of benign cysts.Molecular analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,respectively.The diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic cysts.Genetic analysis performs better for low-and high-risk cysts but has lower diagnostic yield. | Sandra Faias Luisa Pereira Angelo Luis Paula Chaves Marilia Cravo | 2019 | World Journal of Gastroenterology2019，25，26： | 1 |
| 10 | Validation and Simplification of Bethesda Guidelines for Identifying Apparently Sporadic Forms of Colorectal Carcinoma with Microsatellite Instability显示文摘 | Cravo M L Fidalgo P O Lage P A | 1999 | Cancer1999，85，4： | 1 |
| 11 | Serum concentrations of TNF -alpha as a surrogate marker for malnutrition and worse quality oflife in patients with gastric cancer显示文摘 | Correia M Cravo M Marques-Vidal P | 2007 | Clin Nutr2007，26，6： | 1 |
| 12 | Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins B(6) and B(12) status显示文摘 | Cravo ML Camilo ME | 2000 | Nutri- tion2000，16，4： | 1 |
| 13 | Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons显示文摘 | Donato J Jr Cravo RM Frazo R | 2011 | J Clin Invest2011，121，1： | 1 |
| 14 | Organic matter stabilization in a Xanthic Ferralsol of the central Amazon as affected by single trees:Chemical characterization of density,aggregate,and particle size fractions显示文摘 | LEHMANN J CRAVO M S ZECH W | 2001 | Geoderma2001，99，122： | 1 |
| 15 | Minor and trace elements in the shell of Patella aspera (RLding 1798)显示文摘 | Cravo A Foster P Bebianno M J | 2002 | Environment Interna-tional2002，28，： | 1 |
| 16 | Role of the Medulla Oblongata in Hypertension显示文摘 | Eduardo Colombari Monica Akemi Sato Sergio Luis Cravo Cássia Toledo Bergamaschi Ruy Ribeiro Campos Oswaldo Ubríaco Lopes | | Hypertension: Journal of the American Heart Association . 2001 (3, P)0，，： | 1 |
| 17 | Soil microbial activities in tree--Based cropping systems and natural forests of the Central Amazon显示文摘 | Menyailo O V Lehmann J Cravo M D | 2003 | Biology and Fertility of Soils2003，38，： | 1 |
| 18 | Role of the medulla ob- longata in hypertension显示文摘 | Colombari E Sato MA Cravo SL | 2001 | Hypertension2001，38，32： | 1 |
| 19 | Use of 8-hydroxyquinoline-chitosan chelating resin in an automated on-line preeoneentration system for determination of zinc(Ⅱ)by F AAS显示文摘 | Jeferson Schneider Carletto Kalya Cravo Di Pietro Roux Heloisa Franea Maltez | 2008 | Journal of Hazardous Materials2008，157，1： | 1 |
| 20 | Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kissl neurons 显示文摘 | Donato Jr J Cravo R M Frazfio R | 2011 | J Clin Invest2011，121，1： | 1 |
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