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| 1 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 2 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012，，： | 3 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Field evaluation of FR5 glass optical current transducer显示文摘 | N Pawel M W Craig M W Iain | 2000 | SPIE Proc2000，4074，： | 1 |
| 5 | Specificity of class Ⅱ Hsp40 Sisl in maintenance of yeast prion 显示文摘 | Lopez N Aron R Craig EA | 2003 | Molecular Cell2003，14，： | 1 |
| 6 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 7 | Morphologic changes in the peritoneal membrane of patients with renal disease 显示文摘 | Williams JD Craig K J Topley N | 2002 | J Am Soc Nephrol2002，13，2： | 1 |
| 8 | Survival after pulmonary edema due to enterovirus 71 encephalitis显示文摘 | NOLAN N A CRAIG M E LAHRA M M | 2003 | Neurology2003，60，10： | 1 |
| 9 | A novel mutation of WT1 exon 9 in a patient with Denys-Drash syndrome and pyloric stenosis 显示文摘 | Hu M Craig J Howard N | 2004 | Pediatr Nephrol2004，19，10： | 1 |
| 10 | Synthesis of palladium and platinum nanoclusters within microphase-separated diblock copolymers显示文摘 | Chan Y N C Craig G S W Schrock R R | 1992 | Chem Mater1992，4，4： | 1 |
| 11 | Feed restriction significantly alters lipogenic gene expression in broiler breeder chickens 显示文摘 | Rechards M P Stephen M P Craig N C | 2003 | J Nutr2003，133，： | 1 |
| 12 | Automotive crashworthiness design using response surface-based variable screening and optimization 显示文摘 | Craig K J Stander N Dooge D A | 2005 | Engineering Computations2005，22，12： | 1 |
| 13 | The heat shock protein 显示文摘 | Lindquist S Craig N E | 1988 | Annu Re genet1988，，22： | 1 |
| 14 | Extending simulation modeling to activity-based costing for clinical procedures 显示文摘 | Noah D Glick Craig Blackmore C William N Zelman | 2000 | Journal of Medical Systems2000，24，2： | 1 |
| 15 | Subtrochanterie fractures: current management options显示文摘 | Craig N J Maffulli N | 2005 | Disabil Rehabil2005，27，1819： | 1 |
| 16 | Tumor-specific responses in lymph nodes draining murine sarcomas are concentrated in cells expressing P-selectin binding sites显示文摘 | Tanigawa K Takeshita N Craig RA | 2001 | J Immunol2001，167，： | 1 |
| 17 | Morphologic changes in the peritoneal membrane of patients with renal disease显示文摘 | Williams JD Craig KJ Topley N | 2002 | J Am Soc Nephrol2002，13，2： | 1 |
| 18 | Immunoblot evaluation of the species- specificity of Em18 and Em16 antigens for serodiagnosis of human alveolar echinococcosis 显示文摘 | Craig PS | 1997 | Trans R Soc Trop Med Hyg1997，91，4： | 1 |
| 19 | Replacement of fish meal in cobia (Rachycentron canadum)diets u- sing an organically certified protein 显示文摘 | Angela N Lunger S R Craig E McLean | 2006 | Aquaculture2006，257，14： | 1 |
| 20 | Replacement of fish meal in cobia (Rachycentroa canadum)diets using an organically certified protein 显示文摘 | Lunger A N Craig S R McLean E | 2006 | Aqua- Culture2006，257，1： | 1 |
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