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| 1 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 2 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 3 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 4 | Life-cycle reliability characteristics of minimum structures显示文摘 | R G Bea A Brandtzaeg M J K Craig | 1998 | Journal of Offshore mechanics and Arctic Engineering1998，120，： | 1 |
| 5 | Life-cycle reliability characteristics of minimum structures显示文摘 | Bea R G Brandtzaeg A Craig M J K | 1998 | Journal of Offshore Mechanics and Arctic Engineering1998，120，： | 1 |
| 6 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 7 | Theory,instrumentation and applications of magnetoelastic resonance sensors:a review显示文摘 | CRAIG A G SOMNATH C R SANJU R | 2011 | Sensors2011，11，3： | 1 |
| 8 | On the temperature structure of the tropical substratosphere显示文摘 | THUBURN J CRAIG G C | 2002 | J Geophys Res2002，107，2： | 1 |
| 9 | The Role of Interbank Relationships and Liquidity Needs显示文摘 | Craig BR Fecht F Tiimer-Alkan G | 2015 | Journal of Banking & Finance2015，53，1： | 1 |
| 10 | Performance Measurement and Management: A Tool for Strategy Execution 显示文摘 | CRAIG ERIC SCHNEIER DOUGLAS G SHAW RICHARD W BEATTY | 1991 | Human Resource Management1991，30，3： | 1 |
| 11 | Transient expression and insertional mutagenesis of Puccinia triticina using biolistics显示文摘 | CRAIG A W LES J S GUUS B CLARKE G RICHARD C S MERLE E JOHN P F | 2005 | Functional & Integrative Genomics2005，12，： | 1 |
| 12 | Helium isotope ratios in Easter Microplate Basalts显示文摘 | POREDA R J SCHILLING J G CRAIG H | 1993 | Earth Planet Sci Lett1993，119，： | 1 |
| 13 | Synthesis of palladium and platinum nanoclusters within microphase-separated diblock copolymers显示文摘 | Chan Y N C Craig G S W Schrock R R | 1992 | Chem Mater1992，4，4： | 1 |
| 14 | CISK or WISHE as the mechanism for tropical cyclone intensification 显示文摘 | Craig G C Cray S L | 1996 | J Atmos Sci1996，53，23： | 1 |
| 15 | Long QT syndrome:Cellular basis and arrhythmia mechanism in LQT2 显示文摘 | Craig T Qiuming G Zhengfeng Z | 2000 | J Cardiovasc Electrophysiol2000，11，12： | 1 |
| 16 | Metabolism of peptides and amino acids during in vitro protein degradation by mixed rumen or ganisms显示文摘 | Broderick G A Craig W M | 1989 | Journal of Dairy Science1989，72，： | 1 |
| 17 | Risk factors for injuries dur-ing military parachuting 显示文摘 | KnapikJ J Craig S C Hauret K G | 2003 | Aviat Space Environ Med2003，74，7： | 1 |
| 18 | By- stander activation of CD8 + T cells contributes to the rapid production of INF - gamma in response to bacterial pathogens ]显示文摘 | Lertmemongkolehai G Craig G Hunter CA et a/ | 2001 | J Immunology2001，166，2： | 1 |
| 19 | A simple theoretical model for the mtensification of tropical cyclones and polar lows显示文摘 | Gray S L Craig G C | 1998 | Q J R Meteorol Soc1998，124，547： | 1 |
| 20 | Carbapenem - re- sistant Acinetobacter baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences显示文摘 | PLAYFORD E G CRAIG J C IREDELL J R | 2007 | J Hosp Infect2007，65，3： | 1 |
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