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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Detection of genetically modified organisms in food by DNA extraction and PCR amplification显示文摘 | Laurent Thion Christine Vossen Bettina Couderc | 2002 | Biochemistry And Molecular Biology Education2002，30，1： | 1 |
| 3 | Some Physicochemical data on monohydrate citric acid solutions in waier: Solubility, density, viscosity, diffusivity, pH of standard solution, and refractive index 显示文摘 | LAGUERIE C AUBRY M COUDERC J P | 1976 | Journal of Chemical and Engineering Data1976，21，1： | 1 |
| 4 | Therapeutics and vaccines against chikungunya virus 显示文摘 | Ahola T Couderc T Courderc T Ng LF Halleng/ird D Powers A Leeuit M Esteban M Merits A Roques P Liljestr6m P | 2015 | Vector Borne Zoonotic Dis2015，15，4： | 1 |
| 5 | Morphology and electrical properties of biaxially-oriented polypropylene films显示文摘 | UMEMURA T AKIYAMA K COUDERC D | 1986 | IEEE Transactions on Electrical Insulation1986，21，2： | 1 |
| 6 | Highly stable 68 fs pulse generation from a stretched-pulse Yb^3+ -doped fiberlaser with frequency shifted feedback显示文摘 | Albert A Couderc V Barthelemy A | 2002 | IEEE Photonics Technology Letters2002，14，12： | 1 |
| 7 | Silicon deposition from silane or disilane in a fluidized bed-part Ⅰ: experimental study显示文摘 | CAUSAAT B HEMATI M COUDERC J P | 1995 | Chemical Engineering Science1995，50，22： | 1 |
| 8 | Electrical Characteristics and Growth Kinetics in Discharges Used for Plasma Deposition of Amorphous Carbon显示文摘 | Catherine Y Couderc P | 1986 | Thin Solid Films1986，144，2： | 1 |
| 9 | Vehicle driveline behavior: experimentation and simulation 显示文摘 | Couderc P H Callenaere J Hagopian J D | 1998 | Journal of Sound and Vibration1998，218，1： | 1 |
| 10 | Randomised trial of anal- gesic effects of sucrose, glucose, and pacifiers in termneonates 显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，1： | 1 |
| 11 | Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells显示文摘 | Couderc B Zitvogel L Douin-Echinard V | 1998 | Cancer Gene Ther1998，5，3： | 1 |
| 12 | High-energy femtosecond pulses from an ytterbium-doped fiber laser with a new cavity design显示文摘 | Albert A Couderc V Lefort L | 2004 | IEEE Photonics Technol Lett2004，16，2： | 1 |
| 13 | Silicon deposition from silane or disilane in a fluidized bed part Ⅱ: Theoretical analysis and modeling 显示文摘 | CAUSAAT B HEMATI M COUDERC J P | 1995 | Chemical Engineering Science1995，50，22： | 1 |
| 14 | Thoracic radiographic and CT findings of multicentric Castleman disease in HIV-infected patients显示文摘 | Guihot A Couderc LJ Rivaud E | | 0，，02： | 1 |
| 15 | Silicon depositionfrom silane or disilane in a fluidized bed-Part I:Experimentalstudy显示文摘 | B Caussat M Hemati J P Couderc | 1995 | Chemical Engineering Science1995，50，22： | 1 |
| 16 | Laparoscopic intersphincteric resection with coloplasty and coloanal anastomos is for mid and low rectal cancer显示文摘 | Rullier E Sacunha A Couderc P | 2005 | Br J Surg2005，241，3： | 1 |
| 17 | Randomi,sed trial of anagesic effects of sucrose, glucose,and pacifiers in term neonates 显示文摘 | CARBAJAL R CHAUVET X COUDERC S | 1999 | BMJ1999，319，7222： | 1 |
| 18 | A new case of simvastatin-induced acute pancreatitis 显示文摘 | Couderc M Blanc P Rouillon J M | 1991 | Gastroenterol Clin Biol1991，15，12： | 1 |
| 19 | Electro- physiological effects of late percutaneous coronary intervention for infarct-related coronary artery occlusion: the Occluded Ar- tery Trial-Electrophysionlogical Mehanisms (OAT-EP) 显示文摘 | RASHBA E J LAMAS G A COUDERC J P | 2009 | Circulation2009，119，： | 1 |
| 20 | Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus显示文摘 | Liorente L Richaud-patin Y Couderc J | 1997 | Arthritis Rheum1997，40，8： | 1 |
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