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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | 高血压患者颈动脉粥样硬化和脉压及肾血流动力学的关系显示文摘动脉粥样硬化结构性损害、动脉硬化、脉压和肾血流动力学之间可能相互作用与相互影响。肾阻力指数(renal resistance index,RRI)被认为是可预测全身血管变化的一个很好的指标。 | Geraci G MulèG Costanza G Mogavero M Geraci C Cottone S 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 3 | The effect of decoupled low-level flow on winter orographic clouds and precipitation in the Yampa River Valley显示文摘 | Thomas C P L O Grant W R Cotton | 1991 | J Appl Meteor1991，30，3： | 1 |
| 4 | orf virus encodes a functional dUTPase gene显示文摘 | Cottone R Buttner M McInnes C | 2002 | J Gener Virol2002，83，5： | 1 |
| 5 | Mononuelear and Polynuclear Chemistry of Rhenium (liD:Its Pronounced Homophilieity 显示文摘 | COTTON F A CURTIS N F HARRIS C B et a l | 1964 | Science1964，145，： | 1 |
| 6 | Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model 显示文摘 | Jagannath S B Kantsevoy S V Vaughn C A Chung S S Cotton P B Gostout C J | 2005 | Gastrointest Endosc2005，61，： | 1 |
| 7 | Placenta accreta:changing clinical aspects and outcome显示文摘 | Read J A Cotton D B Miler F C | 1980 | Obstet Gyuecol1980，56，1： | 1 |
| 8 | Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1显示文摘 | Carlson J M Brumme C J Martin E Listgarten J Brockman M A Le A Q Chui C K Cotton L A Knapp D J Riddler S A Haubrich R Nelson G Pfeifer N Deziel C E Heckerman D Apps R Carrington M Mallal S Harrigan P R John M Brumme Z L International HIV Adaptation Collaborative | 2012 | J Virol2012，86，13： | 1 |
| 9 | Simultaneous detection of cucumber mosaicvirus, tomato mosaic virus and potato virus Y by flow cytometry显示文摘 | Iannelli DD、 Apice L Cottone C | 1997 | J Virol Methods1997，69，： | 1 |
| 10 | Proposed grading system for subglottic stenosis based on endotracheal tube sizes显示文摘 | MYER C M 3rd O'CONNOR D M COTTON R T | 1994 | Ann Otol Rhinol Laryngol1994，103，41： | 1 |
| 11 | The effect of propofol on the canine sphincter of Oddi显示文摘 | Baron T H Dalton C B Cotton P B | 1994 | HPB Surg1994，7，29： | 1 |
| 12 | The disfeetion costs for inactivating cryptosporiudium 显示文摘 | Cotton C A Owen D W Cline G C | 2001 | J AWWA2001，93，6： | 1 |
| 13 | 查看详情显示文摘 | Cotton F A Eglin J L Hong B James C A | | 0，，10： | 1 |
| 14 | Stray current control in DC mass transit systems显示文摘 | Cotton L Charalambous C Aylott P | 2005 | IEEE Trans on Vehicular Technology2005，54，2： | 1 |
| 15 | Defibrillation or cardiopulmonary resuscitation first for patients with out-of-hospital cardiac arrests found by paramedics to be in ventricular fibrillation? A randomised control trial显示文摘 | Baker PW Conway J Cotton C | 2008 | Resuscitation2008，79，3： | 1 |
| 16 | Damage control resuscitation:the new face of damage control显示文摘 | Duehesne J C McSwain N E Cotton B A | 2010 | J Trauma2010，69，4： | 1 |
| 17 | Characterization of PG2,an early endo PG produced by Sclerotinia sclerotiorum, expressed in yeast 显示文摘 | COTTON P RASCLE C FEVRE M | 2002 | FEMS Microbiology Letters2002，213，： | 1 |
| 18 | vertebra:anatomic alconsi Transpedicular screwing of the seventh cervical derations and surgical technique 显示文摘 | Barrey C Cotton F Jund J | 2003 | Surgical and Radiologic Anatomy2003，25，： | 1 |
| 19 | Indigenous fermentation and soy fortification:effects on protein quality and carbohydrate digestibility of a traditional ghanaian corn meal显示文摘 | Addo K Lykins S Cotton C | 1996 | Food Chem1996，51，3： | 1 |
| 20 | Kurstaki en- dotoxin显示文摘 | Donegan K K Palm C J Fieland V J Changes in levels spe- cies and DNA fingerprints of soil microorganisms associated with cotton expressing the Bacillus thuringiensis vat | 1995 | Applied Soil Ecology1995，2，2： | 1 |
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